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201,169 grants found
Showing 200,901 – 200,920 of 201,169 grants
Optimal Inspired Oxygen during Chest Compressions in Neonatal Resuscitation
ABSTRACT Birth asphyxia is a global issue accounting for about 23% of approximately 2.5 million neonatal deaths each year. These asphyxiated newly born infants require extensive...
Molecular mechanistic studies of long “noncoding” RNAs in mammalian cell differentiation
PROJECT SUMMARY The goal of this study is to determine the molecular mechanisms by which long “noncoding” RNAs regulate mammalian cells differentiation. Long noncoding RNAs (lncR...
Identifying Novel Therapeutics for High Risk Medulloblastoma Patients
ABSTRACT Among pediatric brain tumors, medulloblastoma is the most common form. While most children with medulloblastoma can be cured, ~25% of these kids will die, and those that...
Rapid evolution of pigmentation in D. melanogaster: from cis regulation to phenotype
PROJECT SUMMARY Rapid evolutionary adaptation is a foundational process in biology and at the core of many issues facing humanity including cancer, bacterial and viral diseases,...
Improving the science of adherence reinforcement and safe mobility in people with diabetic foot ulcers using smart offloading
PROJECT SUMMARY/ABSTRACT We aim to reduce the limb-threatening and life-limiting burden of neuropathic diabetic foot ulcers (DFU) by advancing science in its most critical compo...
The Epitranscriptome as a Novel Mechanism of Arsenic-Induced Diabetes.
SUMMARY In the United States, the prevalence of type 2 diabetes mellitus (T2DM) is particularly high among American Indian (AI) communities. Arsenic (As), a pervasive environment...
Microvascular mechanisms of growth restriction after environmental toxicant exposure
ABSTRACT The uterine circulation and placenta are specifically designed to regulate the flow of blood and transport of es- sential nutrients to the fetus. Disruption of maternal...
Mentoring and research to prepare oral PrEP delivery platforms for novel HIV prevention products
ABSTRACT This is a career mentoring award to support Dr. Renee Heffron, Associate Professor at the University of Washington, with protected time to create a more structured appro...
Developmental underpinnings of substantia nigra vulnerability
Abstract: DA neuron degeneration, resulting in deficient DA signaling, underpins the debilitating motor symptoms of Parkinson’s disease (PD). Among DA neurons, those located in ve...
Role of ILC2 and eosinophils in abdominal aortic aneurysm
Abdominal aortic aneurysm (AAA) affects 0.5~3.2% of the general populations in US and worldwide. Besides adjusting lifestyle, open surgery and endovascular stent grafting remain t...
Intermuscular coherence: A novel biomarker for upper motor neuron dysfunction in ALS
Project Summary/Abstract Amyotrophic lateral sclerosis (ALS) is a uniformly fatal neurodegenerative disease caused by neuronal death in the motor system, both in the brain and s...
Comparative Assessment of Modifying Social Determinants of Health to Reduce Firearm-Related Mortality and Disparities
PROJECT SUMMARY/ABSTRACT Gun violence is an escalating national crisis that shapes overall levels of population health including average life expectancy. Crucially, in order to...
Historic Violence and Contemporary Racial Disparities in Birth Outcomes
Abstract Racism and racist structures shape the social environment for all Americans, although the durable imprint of place on health and health disparities remains underexamined...
Non-invasive, Transgene-free, on-demand Pharmacological Modulation of Neural Activity
PROJECT SUMMARY/ABSTRACT Cell-type specific manipulation of neural circuits is required for the treatment of neurological disorders such as epilepsy and autism. Existing technolo...
Itch Ubiquitin Ligase and Germinal Center B cells
PROJECT SUMMARY/ABSTRACT The NIH estimates that up to 23.5 million Americans suffer from autoimmune disease, driven in large part by germinal center (GC)-derived pathologic auto...
Optimization of Lead BKIs for Cryptosporidiosis Therapy
ABSTRACT: Optimization of Lead BKIs for Cryptosporidiosis Therapy The broad, long-term objective of this research is to develop a therapeutic for treatment of Cryptosporidium inf...
The Role of Follistatin Like Protein 1 in the cardiac inflammation of Kawasaki Disease
Project Summary/Abstract: Kawasaki disease (KD), a predominantly coronary vasculitis of childhood, is the most common cause of acquired heart disease of childhood in the developed...
Influence of Opioids on the Brainstem Respiratory Network
PROJECT SUMMARY Many of the 54,000 opioid-related deaths in 2017 were due to respiratory depression. The specific mechanisms by which opioids depress breathing are not fully unde...
GATA Factor Mechanisms in Erythroid Regeneration
ABSTRACT Erythropoiesis, the production of red blood cells (RBCs), is fine-tuned to meet physiological demands. During regeneration or “stress erythropoiesis” caused by anemia, a...
Modeling the dynamicimpact of rare and common genetic variation on gene expression anddisease
Understanding the genetic basis of human disease will require a deep understanding of genetic effects on gene expression. The vast majority of disease-risk loci are non-coding, so...