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44,293 grants found
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How do phagocytes control phagosome fate and pathogen killing?
Our goal is to understand how phagocytic cells control how they kill different microbes. This core role of immune cells is key to preventing infections, but how pathogen processing...
Clonal and functional T cell determinants of protection and pathogenesis in tuberculosis.
Tuberculosis (TB), resulting from infection with Mycobacterium tuberculosis (Mtb), kills 1.5 million people per year. The immune system prevents disease in most people who become i...
Next generation genome annotation for eukaryotic pathogens and vectors, using artificial intelligence
High-quality gene annotation is of vital importance for meaningful interpretation of biological data. Current sequencing technologies permit production of high-quality genome assem...
Data as a foundation for AI innovation and global discovery research in the life sciences
EMBL-EBI's data resources are a fundamental necessity for biomolecular research. Through open data, there is tremendous potential for accelerating scientific understanding and prod...
A randomised trial of adjuvant rituximab in young people with Graves’ disease
Research Question Does a single dose of rituximab administered shortly after diagnosis, in addition to a 2-year course of thionamide antithyroid drug treatment, increase remission...
HElping Alleviate the Longer-term consequences of COVID-19 (HEAL-COVID): A national platform trial
Research question: Can interventions in the convalescent phase of COVID-19 improve longer-term outcomes? Background: COVID-19 is a new disease for which the natural history re...
A UK multi-centre cluster randomised control trial, with internal pilot, of the ADVANCE-Digitally supported perpetrator intervention compared to community justice offender management (1:1), to reduce intimate partner violence (IPV), for men convicted of IPV who misuse substances (ADVANCE-D trial)
RESEARCH QUESTION Is ADVANCE-D for men who misuse substances serving a community sentence or who are on license for intimate partner violence (IPV) perpetration superior in reduci...
NIHR Oxford Health Biomedical Research Centre
Improving brain health: the future in mind One in four people will experience mental illnesses in their lifetime. Whilst some recover completely, many struggle for years with sympt...
Great Ormond Street Hospital BRC
The NIHR Great Ormond Street Hospital (GOSH) Biomedical Research Centre (BRC) in partnership with the University College London (UCL) Great Ormond Street Institute of Child Health...
Spinal Immobilisation Study (SIS)
RESEARCH QUESTION: Is movement minimisation non-inferior (i.e. not unacceptably worse) compared to triple immobilisation in relation to functional outcome (as assessed by the Funct...
Characterisation of the immunological mechanisms that drive chronic chikungunya disease pathogenesis
Chikungunya virus (CHIKV) represents a widespread mosquito-transmitted, arthritogenic virus that causes chronic debilitating joint pain and arthritis in almost half of infected pat...
From cells and synapses to connectivity and cure in paediatric autoimmune encephalitis
Worldwide, one person every minute is diagnosed with encephalitis. An autoimmune cause is now as common as infectious (~27%). Autoimmune encephalitis (AE) patient outcomes remain s...
ThOracic Umbrella RadIotherapy STudy in stage IV NSCLC - TOURIST
Background Non-Small Cell Lung Cancer (NSCLC) is the leading global cause of cancer death with an incidence of >1.2 million; 70% of patients present with incurable disease with tr...
When your body betrays you: interoceptive mechanisms of anxiety after cancer
There is unequivocal evidence that cancer causes anxiety. For some, anxiety resolves following successful cancer treatment. For others, anxiety persists. As cancer survival rates h...
CAMMISA: Climate-focused Analytics and Modelling for Mosquito-borne Infections in Southern Africa
The widespread manifestation of climate change with trends in seasonality and extreme climate events have important implications for Mosquito-Borne Diseases (MBD). The transmission...
Sepsis Trials In Critical Care (SepTIC)
Research questions: 1. Do rapid PCR-based microbiological diagnostics combined with procalcitonin improve outcomes and antibiotic stewardship compared to standard care in patien...
Defining the molecular mechanisms underlying sex-differences in the maintenance of hearing.
Sex impacts the maintenance of hearing over the life course. Onset, severity, and prevelance of age-related/adult-onset hearing loss (ARHL) are not equivalent in men and women, so...
Accelerating Action for Extreme Heat and Health
Within the overall Wellcome Trust-WHO strategic partnership on climate change and health, this project aims to significantly strengthen multidisciplinary capacity and partnerships...
CLArithromycin for post-Stroke Pneumonia (CLASP): A prospective, randomised open-label blinded-endpoint (PROBE) phase 3 multicentre trial
Research question In people with post-stroke pneumonia (PSP), does addition of the immunomodulatory macrolide antibiotic clarithromycin to usual non-macrolide antibiotic treatment...
Rose-NET: Manchester-Leeds Collaborative National Evaluation Team
Aims Our Rose-NET National Evaluation Team aims to conduct national evaluations of health and care innovations. We define innovation as ‘a novel set of behaviours, routines, and...