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Showing 701720 of 44,293 grants

Active EARLY-CAREER AWARD GBP
LEADing the way in dementia research: using AI to accelerate evidence synthesis and discovery
Wellcome Trust University of Edinburgh United Kingdom 2025 – 2030

Despite substantial investment in dementia research, therapeutic options for patients remain limited. To facilitate the planning of new experiments and to inform decision making, t...

£6.86M
GBP
Active CAREER DEVELOPMENT AWARD GBP
Learning to see; The brain as the next frontier in sight rescuing regenerative therapy
Wellcome Trust University College London United Kingdom 2025 – 2033

This program investigates the mechanisms of neuroplasticity essential for sight rescue after regenerative therapy. After decades of research on revolutionary ocular therapies but o...

£27.8M
GBP
Active DISCOVERY AWARD GBP
Mechanisms of symmetry breaking at molecular and cellular scales in planar polarity
Wellcome Trust University of Oxford United Kingdom 2025 – 2030

Symmetry breaking in biological systems is fundamental for pattern formation and elaboration of organismal complexity. In this proposal we seek multi-scale understanding of the sym...

£37M
GBP
Active DISCOVERY AWARD GBP
Medicine without Doctors: Reimagining Care and Voice Through Play
Wellcome Trust University of Edinburgh United Kingdom 2025 – 2031

Medicine without doctors is now a possible and plausible future for healthcare. Already encroached upon by commercial and scientific stakeholders, doctors’ roles in the UK have rec...

£474.24M
GBP
Active STRENGTHENING HEALTH AND DISEASE MODELLING FOR PUBLIC HEALTH DECISION MAKING GBP
CAMMISA: Climate-focused Analytics and Modelling for Mosquito-borne Infections in Southern Africa
Wellcome Trust Clinton Health Access Initiative United Kingdom 2025 – 2030

The widespread manifestation of climate change with trends in seasonality and extreme climate events have important implications for Mosquito-Borne Diseases (MBD). The transmission...

£330.83M
GBP
Active EARLY-CAREER AWARD GBP
Disentangling a new paradigm for mutual homeostasis of aggregation-prone proteins
Wellcome Trust King's College London United Kingdom 2025 – 2030

The dosage of proteins must be regulated in cells, especially for those containing low complexity domains (LCD-proteins) due to their propensity for condensation and aberrant aggre...

£6.09M
GBP
Active RESEARCH GBP
ENTHUSE – EvaluatiNg The High fat sUgar Salt rEgulations: practice, response and impact across retail settings
National Institute for Health Research City St George'S, Universityersity of Lo... United Kingdom 2025 – 2027

Background: Obesity and poor diet constitute two of the greatest threats to population health. The UK government introduced world-first Food (Promotion and Placement) regulations i...

£70.82M
GBP
Active CAREER DEVELOPMENT GBP
Health, socioeconomic, and environmental risk factors for heat-related mortality and hospital admission in England
National Institute for Health Research University College London United Kingdom 2025 – 2029

Background Climate change is causing increasingly frequent and intense heat events worldwide. In England, we are already witnessing the impact of extreme heat on population health,...

£13.65M
GBP
Active DISCOVERY AWARD GBP
Investigating the multiple roles of cryptochromes in animal magnetoreception
Wellcome Trust University of Leicester United Kingdom 2025 – 2030

Many species, including humans, are reported to be magnetosensitive. Indeed, some animals navigate using the weak magnetic field (MF) of Earth. Others do not, but there are account...

£30M
GBP
Active DISCRETIONARY AWARD GBP
Data as a foundation for AI innovation and global discovery research in the life sciences
Wellcome Trust European Bioinformatics Institute United Kingdom 2025 – 2030

EMBL-EBI's data resources are a fundamental necessity for biomolecular research. Through open data, there is tremendous potential for accelerating scientific understanding and prod...

£363.35M
GBP
Active DISCOVERY AWARD GBP
Understanding and manipulating stress signalling: from mechanisms to therapeutics
Wellcome Trust MRC Laboratory of Molecular Biology United Kingdom 2025 – 2032

Numerous stress-signalling pathways are required to ensure cell survival in the face of challenges. My lab aims at identifying strategies that harness these signalling pathways to...

£31.95M
GBP
Active DISCOVERY AWARD GBP
How do phagocytes control phagosome fate and pathogen killing?
Wellcome Trust University of Sheffield United Kingdom 2025 – 2033

Our goal is to understand how phagocytic cells control how they kill different microbes. This core role of immune cells is key to preventing infections, but how pathogen processing...

£378.46M
GBP
Completed DISCRETIONARY AWARD GBP
Support for the 2nd World Conference on Migration, Ethnicity, Race and Health
Wellcome Trust Global Society for Migration, Ethnicity,... United Kingdom 2025 – 2025

The Global Society on Migration, Ethnicity, Race and Health (GSMERH) will hold its second world conference in Lisbon in September 2025. The theme of the conference - Migration as a...

£5.91M
GBP
Active DISCRETIONARY AWARD GBP
Mainstreaming ethics in policy and research: from capacity to translation
Wellcome Trust World Health Organization, Switzerland United Kingdom 2025 – 2030

The experience of the COVID-19 pandemic has reinforced the urgent need for global leadership in supporting and enabling context-sensitive ethical expertise in policy making and res...

£489.29M
GBP
Active CAREER DEVELOPMENT AWARD GBP
Unravelling the lipid landscape in lysosomal storage disorders and associated Parkinson's disease: insights for drug discovery
Wellcome Trust University College London United Kingdom 2025 – 2033

Genetic variants in lysosomal sphingolipid (SL) genes cause lysosomal storage disorders (LSDs) and are strongly linked to Parkinson’s disease (PD) risk. In addition to the lysosoma...

£318.19M
GBP
Active CAREER DEVELOPMENT AWARD GBP
AMEND - eArly Modern European NeuroDivergence
Wellcome Trust University of Oxford United Kingdom 2025 – 2030

This project will significantly shift the understanding of what we currently call neurodivergence by investigating the analogous concept(s) used by early modern people. Establishin...

£9.91M
GBP
Active DISCOVERY AWARD GBP
Collective Action For Race Equity In Health and Social Care (CARE-HSC)
Wellcome Trust Black Thrive Global United Kingdom 2025 – 2031

We aim to significantly advance race equity in health and social care through implementing a bold programme of research to dismantle structures generating and maintaining racial di...

£47M
GBP
Active DISCRETIONARY AWARD GBP
Linking Climate Change and Health for Enhanced Policy Action
Wellcome Trust Meliore Foundation United Kingdom 2025 – 2027

Climate change is one of the greatest threats to human health, yet concerns about the health costs of continued warming and benefits to health of action are still not significantly...

£154.84M
GBP
Active EARLY-CAREER AWARD GBP
A Reproductive Justice Framework for Modern Slavery and Human Trafficking Research and Practice
Wellcome Trust University of Nottingham United Kingdom 2025 – 2029

This is the first research project to apply a reproductive justice (RJ) approach to analyse reproductive exploitation (RE) in modern slavery and human trafficking (MS/HT). This mul...

£7.41M
GBP
Active DISCRETIONARY AWARD GBP
SynHG
Wellcome Trust University of Kent United Kingdom 2025 – 2030

Our long-term vision is to generate scalable technologies for building large chromosomes and genomes, and to actively and continuously inform the development of these technologies...

£98.29M
GBP