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44,293 grants found
Showing 461 – 480 of 44,293 grants
Work-related suicide. An international social justice analysis
This project will undertake a first cross-national, multidisciplinary and qualitative study of work-related suicide in the UK, France and Canada, aiming to generate new knowledge a...
How do CNS border-derived B-cells shape brain immunity and behaviour during chronic infections?
Circadian rhythms and sleep are extremely important processes impacting both our physical and mental health. However, when we experience chronic infections, such as Human African t...
Transforming child health outcomes through data linkage
Survival rates following early life critical illness have improved markedly. However, there is a resulting impact on physical and mental health conditions for survivors. To date, t...
Impact of metabolic cross-feeding interactions in mixed-species chronic wound biofilms on tolerance and evolution of antimicrobial resistance
Studies on the microbial ecology of infected wounds have revealed a diverse array of bacterial species, including antimicrobial-resistant microorganisms, that can play detrimental...
Advancing our Understanding of Intersectionality in Work and Health Research: Training, International Collaboration, and Proposal Development.
The Wellcome Accelerator Award will allow me to develop as an early-career researcher in work and health research by disseminating my thesis, completing training to build my skill...
Understanding and exploiting ribosome biogenesis dysregulation in cancer
Background: Ribosome biogenesis is a highly complex and metabolically demanding process that is essential for protein synthesis in all cells. In normal cells, ribosome biogenesis i...
CRUK Edinburgh-UCL Brain Tumour Centre Of Excellence 2024
Established in 2018, the CRUK Edinburgh-UCL Brain Tumour Centre of Excellence (CoE) is beginning to change the UK brain tumour research landscape by building a critical mass of res...
Enabling Environmentally Sustainable Computational Science through foundational initiatives and the Green Algorithms tools
Computing is an essential component of modern scientific research and it comes with significant, but not well-understood, environmental impacts. Besides, there is a lack of open ac...
Birthing at Burning Places: An ethnographic exploration of intersections among climate-linked risks, maternal nutritional health, and cultural practices in Sindh Pakistan
Extreme weather and natural disasters contribute to a wide range of health, food, and nutritional risks, particularly in low—and middle-income countries such as Pakistan. Women are...
Proposal for pre-treatment CT/MRI derived radiomics and machine learning (ML) models for predicting treatment and immune-response in patients undergoing image-guided ablation and histotripsy for small renal masses and liver tumours. A proof-of-concept study.
Background: Histotripsy is a novel therapeutic technique that employs focused ultrasound waves to create precise, nonthermal, mechanical tissue destruction. Histotripsy has recentl...
The sound of Cancer: towards characterisation of elasticity
Tumours, dysplastic tissue, and single cancerous cells exhibit different stiffness (elasticity) compared to their healthy counterparts. These changes arise at the cellular level to...
Detection and characterisation of p53 aggregates in liquid biopsy with ultrasensitive immunoassays
Background p53 is a pivotal tumour-suppressor that regulates various critical cellular processes. However, p53 can form amyloid aggregates that lose tumour-suppressing functions an...
Advanced Ultrasound Imaging for Early Cancer Detection and Diagnosis
Background: Early detection and clinical intervention of cancer can significantly increase chances of patient survival. Imaging of the microvasculature provides opportunities for e...
Nascent DNA Strand Maturation in Human Cells and its Targeting by Inhibitors of Poly(ADP-Ribose) Metabolism
Background: Inhibitors of the DNA strand break sensor protein poly(ADP-ribose) polymerase-1 (PARP1) are now employed in the clinic, to treat cancers with hereditary mutations in BR...
Integrating the UN SDGs into WTO Law
Sustainability test
Harnessing mechanisms for plant carbon delivery to symbiotic soil fungi for sustainable food production
The arbuscular mycorrhizal (AM) symbiosis between plants and symbiotic soil fungi confers key nutritional benefits to plants: AM fungi increase plant productivity by up to 30% by i...
WeatherGenerator
This project will build the WeatherGenerator – the world’s best generative Foundation Model of the Earth system – that will serve as a new Digital Twin for Destination Earth. The W...
Inhibitor-Mediated Programming of Glycoforms
Site-directed mutagenesis revolutionised the study of proteins and enabled the development of protein-based therapeutics. Our long-term vision is to have equivalent impact through...
Hydrodynamics and Metering of Two-Phase (Liquid/Dense Gas) Flow for Carbon Capture Utilization and Storage
Carbon Capture Utilization and Storage (CCUS) is viewed as an integral component of Net Zero strategy, with significant projects ongoing and planned in both Brazil [1] and UK [2]....
Engineering Combined Sensing and Telecommunications Architectures for Tectonic and Infrastructure Characterisation.
The 5+ Bn km of currently installed data communications optical fibre cable provides an opportunity to create a globe-spanning network of fibre sensors, without laying any new fibr...