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44,293 grants found
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University of Liverpool Translational Instiutional Parnership
The University of Liverpool will work with the Wellcome Trust to build a translational infrastructure to support local University and NHS staff that facilitates expansion and explo...
Engineering genomic features to better understand the molecular basis of immune mediated diseases and their treatment
Genetic and transcriptional studies have demonstrated that shared aetiology between immune-mediated diseases (IMD) is reflected in shared patterns in both data types, and suggested...
Molecular mechanisms determining the polarised synaptic distribution and molecular function of the retrograde endocannabinoid signalling system
The endocannabinoid system (ECS) acts as a negative feedback mechanism to suppress excitatory and inhibitory synaptic transmission. This is critically important for a wide range of...
Elucidating the mechanisms and functions of bacterial-derived mediators on Plasmodium falciparum.
Some bacteria species in the mosquito midgut demonstrate anti-Plasmodial effect independent of the mosquito immune system.Understanding this mechanism could help propose bacteria-m...
Does stroke impair immunological memory and increase infectious disease risk during the chronic phase of recovery
Stroke patients are increasingly surviving long-term after the primary neurological insult. Post-stroke complications have thus rapidly become an area of unmet clinical need. Infec...
Next Generation Data Formats for BioImaging
Bioimaging measures the structure, constitution and dynamics of molecules, cells, tissues and organisms in biological systems.Data are often GBytes or Tbytes in size, cover space,...
Extracellular polycation signalling in alveolar and systemic inflammation
Critically ill patients with pneumonia often have impaired neutrophil function and disruption of alveolar-capillary barrier integrity.During inflammation, excessive polycation gene...
Molecular basis of parasite-induced disruption of host circadian outputs
Sleep/wake cycles are arguably the most important circadian behavioural output controlling many aspects of animal physiology. However, some infections induce disruptions to these c...
Contribution of the miRNA-interferon interaction to human disease
The type I interferon (IFN) response is the major antiviral pathway in mammals but needs to be tightly regulated to ensure effective defence against viruses whilst avoiding the neg...
Impaired maternal β-cell adaptation to pregnancy: effects on glucose homeostasis in mother and offspring
Gestational Diabetes Mellitus (GDM) is associated with deleterious outcomes for both mother and baby, and the incidence of this metabolic disorder is on the increase.The complex ph...
Novel multi-nuclear magnetic resonance spectroscopy approaches for the sensitive and robust assessment of human cardiac energetics
Altered cardiac metabolism is now recognized as an important component of many cardiovascular diseases, including heart failure.Accurate assessment of cellular energetics promises...
Taking the long view: Identification of plasma protein biomarkers for dementia risk
The overarching goal of this collaborative project is to make a step change in knowledge of dementia biomarkers by focusing on plasma proteome.We hypothesize that plasma is biologi...
Plasmid biology in human adapted pathogens
Plasmids are responsible for virulence and antimicrobial resistance in many bacteria.We will dissect fundamental mechanisms of plasmid maintenance in the obligate human pathogens,...
A cross-species, cross-modal approach to computational neuroanatomy
In vivo methods for mapping brain connections are increasingly used in systems neuroscience but are yet to have significant clinical impact.We propose to develop new computational...
TRANSCRIPTIONAL REGULATION OF SELF-RENEWAL IN HUMAN HAEMATOPOIETIC STEM CELLS
Generation of functional HSC from pluripotent cells and robust HSC expansion in culture are limited by our incomplete understanding of the self-renewal process.My goal is to unveil...
Interventions for the treatment of COVID-19: a network meta-analysis (Methodologically complex living systematic review with network meta-analysis)
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Longer Term Impact Of COVID 19 Infection People With Diabetes
People with diabetes have suffered greater adverse consequences of COVID-19 in the acute phase of infection during the pandemic. Whether they also have increased susceptibility to...
Defining And Understanding The Longer-Term Effects Of COVID-19: A Mixed Methods Study Exploring The Frequency, Nature, And Impact Of ‘Long COVID’ In The Scottish Population
Most people with COVID-19 recover within three weeks, but some don’t. Our study will identify how many people continue to be unwell, their symptoms, and how it affects their lives....
Lived Experience Of Long Term COVID-19 On NHS Workers In Health Care Settings In Scotland: A Longitudinal Mixed Methods Study
Many NHS workers have greater occupational risk of exposure to COVID-19 than the general population.UK studies found the risk of healthcare workers testing positive for COVID-19 wa...
Prevention And Early Treatment Of COVID-19 Long Term Effects: A Randomised Clinical Trial Of Resistance Exercise
Many people have long-lasting symptoms after COVID-19, such as breathlessness, fatigue and chest pain.So far, research studies of treatments for COVID-19 have focused on the life-t...