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15,626 grants found
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Deciphering the molecular landscape in chronic lymphocytic leukemia: clinical and biological impact
Chronic lymphocytic leukemia (CLL), the most common leukemia among adults, is known for being highly heterogeneous in terms of clinical manifestation and outcome. Taking advantage...
Starved to death? Exploring the care of ´untidy uneducable feebleminded´ patients at Vipeholm asylum
In 1941-1943 200 patients died in a sudden rise of mortality at the Vipeholm asylum in Sweden for intellectually disabled, classified as ´untidy uneducable feebleminded´. The death...
Evaluation of necrosis formation as a robust tool in tree resistance breeding
Scientific studies often evaluate tree resistance using bioassays where trees are artificially infected by a pathogen, and the resistance is evaluated based on the length of the ne...
Characterization of susceptibility and resistance to novel categories of anti-HIV compounds
Antiretroviral therapy (ART), although still effective, is associated with long-term complications such as cardiovascular and metabolic diseases and increasing rates of drug resist...
Human ovarian cell map from womb to menopause for data-driven development of folliculogenesis in vitro
Female fertility depends on ovaries that harbor the reserve of immature oocytes and produce hormones. Incontrast to men, fertility in women is limited ending in menopause. The limi...
Shaping foreignness. The effects of state action on social categorization processes in colonial Latin America, 1590-1700
After a large immigration wave, a social challenge is to understand how social perceptions and attitudes towards foreigners and migration emerge and change. How do society and poli...
Advanced signal processing in the peripheral nervous system: from single neurons to complex human behavior
Fundamental elements of higher-level functions such as sensory attenuation and multisensory integration are believed to depend solely on neural circuits in the brain. I propose tha...
Biomimetic fabrication through robotic 3d printing
This purpose of this project is to develop a novel way of investigating and implementing biological design principles within architectural desing contexts. Taking its starting poin...
SET4Pro: Single-electron transistors for studies of redox proteins
Electron transfer reactions, executed by redox proteins, are an essential part of many important biological processes such as photosynthesis, respiration, and DNA synthesis. Moreov...
Promoting inclusive educational environments for children with autism and other social-communication challenges: Preschool class and primary school
Researchers agree that evidence-based educational practices (EBP), adapted to the needs of children with autism spectrum conditions (ASD) and related social-communication challenge...
Correlative cytometry to measure biophysical properties of cells in health and disease
Our cells can alter their properties as a result of diseases or as response to environmental changes to be able to adapt and fulfil their function. Although numerous studies aimed...
Organ-specific origins, regulation and functions of lymphatic vessels in development and disease
Lymphatic vessels within different organs have diverse developmental origins and exhibit remarkable tissue-specific specialisation. We hypothesise that uncovering organ-specific fe...
Parkinson´s disease: interplay of cells and circuits in the genesis of movement disorders
In Parkinson’s disease (PD), loss of dopamine (DA) in the striatum causes poverty of movement (hypokinesia) while DA replacement therapy with L-DOPA can cause excessive abnormal mo...
Multiple sclerosis; from disease mechanisms to optimized treatment
Multiple sclerosis (MS) features aberrant adaptive immune reaction towards central nervous system antigens leading to myelin and neuron/axon damage. Highly effective disease modula...
Timing many-body processes in small quantum systems
The rapid light-source development is advancing on several frontiers. One is the quest for ever shorter light-pulses. Attosecond light-bursts enable experiments that follow the dy...
Discovery, fundamental recognition, and applications of non-carbohydrate and of macrocyclic glycomimetics targeting CNS
A first aim is to improve understanding of protein-ligand binding. Emphasis is on poorly understood entropic changes and how this is affected by ligand (macro)cyclization. A multid...
Legal identity under insurgencies and unrecognised states
Legal identity comprises a documented relationship between a person, the law and the state. Some insurgencies seek to replace the state and start issuing legal identity documents (...
Molecular design of protein nanofibrils for new materials
New materials will unavoidably have key roles in the transformation to a sustainable society. Although some of the most fascinating materials in nature are built from proteins, the...
Inflammation, ateroskleros och hjärtkärlsjukdom
Bakgrund: Ateroskleros orsakar de flesta fall av hjärtinfarkt och stroke. Nya metoder för prevention, diagnostik och terapi behöver tas fram vilket kräver fördjupad kunskap om sjuk...
Illuminating kilonovae and Type Ia supernovae
The project aims at illuminating kilonovae and Type Ia supernovae using radiative transfer simulations, with a focus on exploring the asymmetric nature of these explosions. Realist...