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15,626 grants found
Showing 14,481 – 14,500 of 15,626 grants
Innovative exercise for extrapulmonary benefits in COPD: feasibility, effects & mechanisms of supramaximal high-intensity training: an international multidisciplinary and translational research project
BACKGROUND The rationale behind this translational research project is that the course of chronic obstructive pulmonary disease (COPD) is intimately linked to extrapulmonary manif...
Personalized anti-fracture treatment
With increasing age of the population, industrialized countries across the globe are facing a substantial increase in osteoporotic fractures, which account for considerable disease...
Polarization as a challenge to government formation in parliamentary democracies
The role of globalization in shaping modern politics has reached historic importance, with unprecedented support for anti-globalization parties across the Western world. Many schol...
Beyond the code: revealing the core microRNA-mediated gene regulatory networks in human skin wound healing
Chronic wounds are common and severe diseases lacking effective treatment. To identify new therapeutic targets, a better understanding of the related molecular pathogenesis is a pr...
Assessing the extent and conservation implications of introgression between domesticated and wild arctic foxes
Domesticated species diverge from their wild ancestors through artificial selection on specific traits and random genetic changes arising from relaxed selection pressure and geneti...
Digital tools for the valuation of land in urban development projects
This project aims to develop the knowledge and the digital tools necessary to describe, control and evaluate urban systems effects and economic externalities typically created in u...
Agents of change within the colonial state? The role of ‘interface bureaucrats’ in consultations on natural resources
The duty of states to consult Indigenous communities about resource developments is central to international law and new procedures are being developed, globally. Scholarly work ha...
Role of carbohydrate quality for cardiometabolic risk
The role of sugar and starch consumption in the development of cardio-metabolic diseases has received great attention, but whether the consumption plays a key role is not yet known...
Transcription factors in Parkinson´s disease
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of midbrain dopaminergic neurons (mDAs). The treatment of PD is currently symptomatic and there i...
Identifying molecular mechanisms and therapeutic targets in childhood neural tumors
Medulloblastoma and Neuroblastoma are among the most common neural tumors in children. Neural tumors constitute around one third of all childhood cancers, but almost half of the mo...
“Anhedonic depression” as a novel, mechanism-based subtype of depression -- Treatment implications for precision psychiatry
Treatment of depression is hampered by the failure to identify distinct symptom profiles with distinct pathophysiologies that differentially respond to distinct treatments. We posi...
Restored wetlands - potential hotspots for emissions of the green-house gas methane?
Wetlands are unique ecosystems delivering important ecosystem services to society. Due to extensive drainage only a minor fraction of the original wetland areas still remain in e.g...
Targeting NOX2 in cancer – a translational approach
This program comprises studies of the potential impact of the myeloid cell NADPH oxidase 2 (NOX2) and NOX2-derived reactive oxygen species (ROS) for the expansion and metastatic sp...
Micro meets macro: Peasant diaries and the transformation of Sweden 1840-1920
The project studies a local rural context and its members over the agricultural and industrial revolutions using peasant diaries and other sources. It addresses our overall view of...
Aortic valve disease and associated thoracic aortic aneurysm
Ascending aortic aneurysm is a silent disease and the first clinical manifestation is often aortic dissection or aortic rupture, both lethal conditions unless surgery is performed...
An integrated landscape-atmosphere-industry greenhouse gas budget of forest biomass production: Does sustainable forestry result in negative emissions?
Forest biomass production constitutes a key component in developing Sweden’s bio-based economy. Furthermore, forest management can counteract emissions from fossil fuel burning by...
Controlling the Uncontrollable: The Impact of Reproductive Health Apps on Experiences of Pregnancy, Healthcare Professionals’ Work, and Data Privacy.
Digital smartphone applications for reproductive health (RHAs) are big business. Millions use them to track intimate data such as menstruation, fertile days or fetal developments....
Setting the stage for genomic selection in birch in a changing climate
Two major changes are profoundly reshaping plant and animal breeding: the first one is genomic selection and the second global climate change (GCC). Both imply a reorganization of...
Viral tropism and host responses in the brain
Neurotropic flaviviruses, including West Nile virus, Zika virus, and tick-borne encephalitis virus cause serious disease in people worldwide, and are particularly efficient in inva...
USING -OMICS TECHNOLOGIES TO DISCOVER NEW PATHOPHYSIOLOGICAL PATHWAYS FOR THE FOUR MAJOR CARDIOVASCULAR DISEASES A TRANSLATIONAL APPROACH
Bakgrund:The four most common cardiovascular diseases (CVD) are myocardial infarction, ischemic stroke, heart failure and atrial fibrillation. Many patients suffer from more than o...