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15,626 grants found
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Unwilling or unwanted? Explaining the decline of mediation in armed conflicts
At the core of international mediation lies an underexplored puzzle, which this project seeks to resolve: while the capacity to mediate in armed conflicts has expanded immensely ov...
Premenstrual dysphoric syndrome - role of progesterone and serotonin
Premenstrual dysphoric disorder (PMDD) is a common mood disorder, characterized by distressing affective, behavioural and somatic symptoms in the late luteal phase of the menstrual...
Drönare som räddar liv vid plötsligt hjärtstopp
Background Out of hospital cardiac arrest (OHCA) affects 275 000 individuals in Europe each year and survival rates are low (11 %). There is an urgent need for novel methods that...
Ambiguities of Hospitality: Intercultural Integration and Conflict in Host-Guest Relations on the European Borderlands, c. 1000-1350
This project studies the linguistic and ritualistic expressions of hospitality as means of intercultural integration and conflict in the European borderlands in the high Middle Age...
Molecular characterization of asthma phenotypes – A translational approach
Current challenges in asthma disease management are likely related to the high degree of heterogeneity of the disease. Inhaled corticosteroids, which decrease airway type 2 inflamm...
The puzzle of forestry and ungulate interactions – a missing piece is in the understory
Dwarf-shrubs, including bilberry, cowberry, and heather, often dominate understory vegetation at northern latitudes. These plants provide a range of ecosystem services and essentia...
A multi-species approach to unlock the disease and treatment mechanisms of obsessive-compulsive disorder: Expansion of the World’s largest biobank for novel genomic studies
Obsessive-Compulsive Disorder (OCD) is a serious and heritable (~40-50%) psychiatric disorder that causes enormous personal and societal costs. After decades of molecular genetic r...
Taurine and its involvement in addiction
This project focuses on mechanisms underlying addiction to alcohol and other drugs of abuse, with emphasis on the endogenous amino acid taurine. We will study the origin of ethanol...
Migratory patterns and productivity potential of juvenile Sea Trout (MAPS)
In Sweden, sea trout is an important resource with increasing interest from anglers, but little is known about factors determining its population size. In 2016, sea trout in Sweden...
Development of novel NK cell-based immunotherapies for treatment of human hematological malignancies
Novel cancer immune-therapeutics, currently dominated by CAR-T and checkpoint-inhibition (mAb) therapies, are in select cases highly effective and even curative. However, signific...
Artificial intelligence for reproducible MRI diagnosis of prostate cancer
Diagnosis of prostate cancer (PCa), which is the most common cancer with the highest mortality among males in Sweden, has for decades been established by trans-rectal ultrasound (T...
Development of a RadioImmunoTheranostic Agent Targeting LRRC15 - a TGFβ-driven Biomarker Specific to Mesenchymal Stem Cell Derived Cancer Cells and Tumor Stroma
The tumor stroma has a critical impact on disease progression, metastasis and treatment outcomes. Leucine-rich repeat containing 15 (LRRC15) is highly expressed on cancer associate...
Oxidative reactivity and physicochemical characteristics of mixtures of airborne particles from indoor and outdoor sources in indoor environments
We will determine reactive oxygen species (ROS) formation potential, a marker of toxicity, and physicochemical characteristics of mixtures of airborne particle originating from ind...
Defining the role of a newly discovered unconventional T cell subset during myelodysplastic syndrome progression and therapy
Myelodysplastic syndromes (MDS) arise from malignant transformation of the primitive hematopoietic stem cell in the bone marrow (BM). The only curative therapeutic option for MDS p...
Water quality and the legacy of historical ditching: Is wetland restoration amd ditch-cleaning a sustainable way forward?
Peatland drainage the last century has created about 1 million km of artificial streams, making it one of the most widespread human-induced environmental disturbances in Sweden. Th...
The red blood cell: Mediator of cardiovascular disease and novel target for treatments
Background and aimThe project is focused on the red blood cell (RBC) as a previously unknown mediator of endothelial dysfunction and cardiac injury in cardiovascular disease (CVD)...
Novel cancer-targeting strategies for improved molecular radiotherapy
This project focuses on improving therapeutic effects of radiotherapy by:➢ Creating novel radioactive cancer-targeting molecules for molecular radiotherapy➢ Utilizing state-of-the-...
Pathogenic mechanisms and effects of treatment in chronic rheumatic muscle inflammation, myositis
Myositis is a complex autoimmune disease with high morbidity and mortality. Biomarkers to predict prognosis are lacking. Newly discovered myositis-specific autoantibodies predict d...
Mapping clitics: from cartography to geography
The project will chart the behaviour of clitics across two linguistic areas, the Balkan and northern Austronesian, both of which display extreme diversity in their clitic systems,...
What makes preschool wheeze persist as childhood asthma? - Development of dynamic ribonucleic acid biomarkers for diagnosis and prognosis
Bakgrund: Asthma is a complex disease with genetic and environmental contribution. No biomarkers exist that could accurately diagnose or prognose asthma, predict the outcome, moni...