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15,626 grants found
Showing 541 – 560 of 15,626 grants
Nordic Research Network on Teaching and Learning in Innovative Learning Environments
The Nordic Network on Research in Innovative Learning Environments (NNILE) comprises four research groups from four key institutions: Umeå University, Norwegian University of Scien...
Molecular movies of large non-coding RNAs assembling into functionally-active 3D structures
Many non-coding RNAs (ncRNAs) rely on three-dimensional (3D) structures to perform their cellular functions, but the underlying mechanisms by which RNAs acquire 3D structures are s...
Mountains in a warming world: biotic refugia or elevators to extinction?
While no palaeoclimate is a perfect equivalent for future climate scenarios, the geobiological record is our only observational precedent for how ecosystems may respond in a rapidl...
Timing many-body effects in atomic systems
Light-sources based on the process of High-Harmonic Generations provide now increased repetition rates, as well as photon energies approaching the soft-X-ray region, at the same ti...
Racism and anti-racism in elementary school - A study on how everyday racism emerge and is challenged in different school contexts
The purpose of the project is to contribute with knowledge about how everyday racism emerge and is challenged in elementary school in Sweden. Racism is a part of many students´ eve...
New Strategies for Studying Neuroinflammation in the Living Human Brain using Positron Emission Tomography
This project seeks to advance the use of Positron Emission Tomography (PET) for studying neuroinflammation (NI). PET enables quantification of molecular targets of NI both during d...
Clonal analysis reveals epigenetic drivers of craniofacial birth defects
During embryogenesis, mesenchymal stem cells regulate cell division rates and cell differentiation in order to properly form skeletal elements like cartilage and bone, but how this...
Exploring molecular mechanisms by which microbially produced metabolites protect against or promote type 2 diabetes
Type 2 diabetes (T2D) is a common condition of diverse aetiologies diagnosed by high blood glucose levels. Over the past 20 years it has become evident that the gut microbiota is a...
Dynamics of thin-film equations
Thin liquid films are omnipresent in nature, daily life, and industrial processes, with extensive use in various coating teachniques such as spin coating, responsive coating and bi...
Interprofessional Coaching to Enhance Language and Learning in Secondary Classrooms Using Digital Education for Teachers (INCLUDE)
INCLUDE aims to enhance learning and participation in secondary classrooms through a digital teacher professional development program called LINK-D, where teachers get techniques t...
Accelerating sparse linear algebra with graph neural networks
We aim to accelerate sparse linear algebra by harnessing the power of machine learning, specifically graph neural networks (GNNs). Sparse linear algebra is pivotal in solving large...
Goblet cells as regulators of colonic immunity: implications for the pathogenesis of colitis
Ulcerative colitis (UC) is a chronic disease with unknown etiology. The current understanding of UC is that the inflammation targets gut bacteria, but detailed understanding of why...
Dissecting tissue resident lymphocyte homeostasis in human cancer
Natural killer (NK) cells play a crucial role as early immune effectors in the defense against cancer, existing both in peripheral blood and as tissue-resident (TR) cells in human...
Invasion Frontiers in Liver Metastases: From Cellular Processes to Novel Therapeutic Strategies
Metastases are the main cause of cancer mortality. In liver metastases, prognosis depends on the histological pattern of the invasion front: Extensive tumor-hepatocyte contact is l...
Defining the role of antioxidants and BACH1 in tumor angiogenesis and metastasis
Our group discovered that antioxidant supplementation of the diet accelerates cancer progression and metastasis and that this effect is partly mediated by the redox-sensitive trans...
Stress-induced chromatin remodelling in health and disease
The human genome´s accessibility is tightly controlled by its organisation into chromatin. Cellular stresses, like DNA damage and protein misfolding, trigger transient chromatin re...
Neural circuits in semaglutide-induced weight loss
Semaglutide is a long-acting GLP-1 analogue that has revolutionized the treatment of obesity, but its brain-mediated mechanisms are unclear. The overarching goal of my research is...
Deciphering macrophage- and stem cell-driven adipose tissue remodeling as a means to treat and prevent metabolic diseases
Obesity and polycystic ovary syndrome (PCOS), a hyperandrogenism condition affecting women, are often associated with adipose tissue dysfunction, leading to ectopic lipid depositio...
Identifying ligands for the activating NK cell receptor NKp46
Natural killer (NK) cells are innate effector cells that participate in defense against viral infections and malignancies. The cytotoxicity of NK cells is regulated by a battery of...
Spatial biology of membrane proteins
Most drugs in clinical use target membrane proteins. Accumulating evidence shows that most membrane proteins are not uniformly distributed but localize to dynamic domains of nanosc...