Browse All Grants
15,626 grants found
Showing 441 – 460 of 15,626 grants
Integrated preclinical and clinical studies of alcohol use disorder
This translational project explores the neurobiology of alcohol dependence focusing on ethanol´s acute and chronic interactions with the dopaminergic reward system.We have revealed...
Decoding viral evolution in real time and assessing its impact on host innate immune responses
It is a natural occurrence that viruses and humans co-exist.Although the acute phase of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic is behind us, the...
Unraveling the Oral-Gut axis during intestinal disorders.
Despite growing evidence for a bidirectional oral-gut axis, the mechanisms of remote interaction - particularly how gut disorders affect the oral cavity - remain elusive.Filling th...
Molecular and cellular defense against Retinopathy of Prematurity - Prevention, prediction, diagnosis and treatment
In preterm born infants, Retinopathy of Prematurity (ROP), a blinding disease, occurs due to loss of the intra-uterine environment.Preterm born infants are exposed to factors usual...
Economic impact and value of prevention of eating disorders in Sweden
Research problem and specific questions: Eating disorders (EDs) are some of the most severe and disabling mental health disorders, with impacts on individuals´ physical and mental...
TeamBirth - an intervention to improve patient safety and person-centered care during childbirth
Most adverse events within maternity care stem from communication and teamwork failures.Despite national and international recommendations, few interventions include person-centere...
Mapping and treating circuit dysfunctions in Parkinson´s disease
We aim to unravel the role of specific neuronal circuits, dopamine receptors (DAR), and large-scale brain networks in the motor and neuropsychiatric dysfunctions of Parkinson´s dis...
Genetics of preterm delivery and its cellular mechanisms: beyond genomics discoveries
Preterm delivery is the leading cause of death in children under 5-years of age and long-term child morbidity.The preterm delivery rate has not shown any notable reduction, partly...
Accessing regional health data for the study of multiple sclerosis: From predictors to precision medicine
Multiple sclerosis (MS) is a chronic disabling disease of the brain and spinal cord with an unknown aetiology.In recent years, researchers have discovered a ‘prodromal’ period befo...
Changes in chromosome numbers in pediatric leukemia: how, why and when?
Aneuploidy, i.e., changes in chromosome numbers, is a common phenomenon in cancer cells.In the proposed project I will study two types of aneuploid pediatric acute lymphoblastic le...
Illuminating neutrophils dark microproteome against fungal pathogens
The human genome contains thousands of unannotated short open reading frame (sORF) encoded microproteins, which are potential functional peptides waiting to be discovered.Despite t...
Cellular and Molecular mapping of the blood nerve barrier during health and disease
The entire central and peripheral nervous systems (CNS and PNS) are shielded from potentially neurotoxic molecules in the circulation by the blood-brain and blood-nerve barriers.Do...
Frizzleds as dynamic, pharmacological and druggable entities
Diverse signaling systems are attractive targets for anti-cancer therapy, one of which is the WNT/Frizzled signaling system, where secreted WNT proteins activate Frizzled receptors...
Spatial and single-cell proteomics of metabolic disorders
Mitochondrial metabolism is constrained by the available resources within its host cells and surrounding tissue.Enzymatic sets are dynamically expressed upon internal and external...
Common factors contributing to poor reproductive outcome from failed implantation to pregnancy loss
Motherhood holds a profound significance for many women, yet one in six couples encounters infertility. In vitro fertilization (IVF), the most common treatment, yields modest pregn...
Visualizing evolution of resistance in breast cancer tumors through In Situ Sequencing
Intratumoral heterogeneity is a critical driver of tumor resistance, as varying populations of cancer cells within a tumor can exhibit different sensitivities to treatments.This dy...
Alkoholbruk trots negativa konsekvenser: En translationell strategi
Alcohol addiction leads to continued alcohol use despite adverse consequences (“compulsivity”).We have found that a minority of outbred rats show punishment-resistant, compulsive-l...
Receptor-mediated mechanisms in Parkinson´s disease and depression
This programme aims at providing better biomarkers anbd mechanism-based therapies for two common diseases: Parkinson´s disease (PD) and Major depressive disorder (MDD). Besides mot...
Mechanisms of antiviral defense in the CNS - uncovered through patient-mimicking transgenic mice and human brain organoids
Viral infections can cause devastating diseases if not controlled by the immune system.This includes diseases in the central nervous system (CNS) where e.g. herpes simplex virus 2...
Building Bone: Harnessing Fetal Mesenchymal Stem Cells to Treat Osteogenesis Imperfecta.
Our aim is to harness the full potential of our recently developed fetal mesenchymal stem cell (fMSC) therapy.We are currently about to change the lives of people living with Osteo...