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Integrated preclinical and clinical studies of alcohol use disorder
| Funder | Swedish Research Council |
|---|---|
| Recipient Organization | University of Gothenburg |
| Country | Sweden |
| Start Date | Jan 01, 2025 |
| End Date | Dec 31, 2027 |
| Duration | 1,094 days |
| Number of Grantees | 3 |
| Roles | Principal Investigator; Co-Investigator |
| Data Source | Swedish Research Council |
| Grant ID | 2024-02466_VR |
Grant Description
This translational project explores the neurobiology of alcohol dependence focusing on ethanol´s acute and chronic interactions with the dopaminergic reward system.
We have revealed that glycine and nicotinic receptors are involved and shown that high ethanol intake in rats can be reduced by manipulating these receptors.
We have translated parts of these findings to humans in controlled clinical trials and are currently developing a new pharmacological treatment principle based on the results.
Our preclinical work continues in order to further develop and refine our concepts and for finding new treatment targets.
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University of Gothenburg
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