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99,167 grants found
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Uncovering the Mechanisms of Amylopectinosis in LUBAC Deficiency
PI: Mitra, Sharmistha Glycogen is the largest soluble macromolecule in the cell and serves as a critical energy store in tissues. Co- ordinated actions by multiple enzymes control...
Feasibility of Tele-Singing at Home for Older Adults with Mild Cognitive Decline
ABSTRACT An estimated 6 million adults aged 60 and over in the United States have Alzheimer’s disease and related dementias (AD/ADRD) at a cost of $345 billion per year. Older adul...
Achieving Independence and Mastery in Schools – An RCT for Middle-Schoolers with Autism
Project Summary/Abstract Children with Autism Spectrum Disorders (ASD) present with numerous deficits in organization, planning, prioritizing, memory, and materials management (OPM...
Gene Therapy for Xeroderma Pigmentosum - Cockayne Syndrome.
PROJECT SUMMARY The goal of this project is to refine our gene therapy strategy for Xeroderma Pigmentosum-Cockayne Syndrome (XP-CS), with the ultimate aim of improving the neurolog...
Potential miRNA biomarkers and miRNA regulatory targets underlying early congnitive impairement and progression to Alzhiemer's disease
Abstract Alzheimer’s’ disease (AD) affects an estimated 6.7 million people aged 65 and older in the US and the number could grow to 13.8 million by 2060. Despite major efforts to a...
Development and Pilot Testing of a Combined SMART and Tai Chi Intervention for Asian Americans with Depression and Somatic Symptoms
Abstract Asian Americans (AAs) have a distinct pattern of underutilization of mental health services, characterized by delayed onset of treatment and higher attrition rates. Many d...
Understanding cell chirality and cell-cell interactions at neurovascular unit after brain injury
Project summary/abstract The neurovascular unit (NVU) is responsible for the maintenance of blood-brain barrier (BBB) integrity, cerebral homeostasis, and control of cerebral blood...
A novel platform for the discovery and characterization of migraine therapies
PROJECT SUMMARY A major obstacle for the identification and characterization of new therapies for migraine and pain has been limitations of the animal models used to study these th...
Development of a pre-clinical syngeneic pig glioma model for research and translational studies
Glioblastoma (GBM) is uniformly fatal with an incidence rate of 2.99-3.23 per 100,000 people. Despite recent therapeutic advances, our understanding of tumor biology in GBM remains...
Improving Non-Viral Gene Delivery, Integration, and Expression Methods for Cell Therapies
PROJECT SUMMARY Since 2017, six CAR-T cell therapies and four hematopoietic stem cell (HSC) therapies have been approved in the U.S. and E.U. to treat cancers, hemophilia, ALD, MLD...
Dietary lipids as drivers and therapeutic targets in obesity-accelerated breast cancer
Summary Diet-induced obesity affects about 40 percent of US women and increases the incidence, morbidity, and mortality of postmenopausal breast cancer (BC). Obesity also increases...
Anti-inflammatory signals and neurodegeneration
Abstract Neuroimmune signals regulate neuronal function and survival. We have obtained multiple pieces of evidence indicating that activation of the heterodimeric interleukin-13 re...
Extracellular Matrix Regulation of Airway Epithelial Homeostasis
Project Summary Airway basal epithelial cells (BCs) play critical roles in lung homeostasis particularly in repair from injury reflecting their ability to differentiate into and re...
Families Moving Forward Bridges: An Early Intervention Enhancement for Infants and Toddlers with Prenatal Alcohol Exposure with or at-risk for Fetal Alcohol Spectrum Disorders
Project Summary/Abstract Prenatal alcohol exposure (PAE) can lead to a fetal alcohol spectrum disorder and a lifetime of neurodevelopmental disabilities and problems of daily livin...
Vaping Cessation among youth: Evaluating the feasibility and efficacy of a virtual in-person CBT and an app-based CBT4CBT
PROJECT ABSTRACT E-cigarettes are the most popular nicotine-delivery devices used by US adolescents. Many adolescents do not like being addicted to e-cigarettes and want to quit. H...
Developing and Evaluating a Perceived Access Metric for Global Mental Health
Access to mental health care is a fundamental human right that should be a critical performance metric for all governments and healthcare systems. However, there are few psychometr...
Determinants of transitioning from injecting to smoking fentanyl and methamphetamine and implications for harm reduction implementation
PROJECT SUMMARY/ABSTRACT The proposed R36 dissertation research project will identify trends and multilevel determinants of transitioning from injecting to smoking drugs (predomina...
A mechanistic 3D AI-powered map of genetic chILD
ABSTRACT/SUMMARY Leveraging the technologies and infrastructure in our previous LungMAP phases, we will construct a multi-scale map of developing acinar and alveolar structures dur...
TLT-1 intracellular function
Project Summary/Abstract TREM Like transcript (TLT-1), is a highly abundant platelet protein that mediates the earliest states of platelet activation. Inhibition of TLT-1 function...
Using Event Momentary Assessment and Actigraphy to Investigate Mediating and Moderating Processes of Discrimination's Negative Effect onSleep
Project Summary/Abstract Objective: The proposed study explores mediators and moderators of discrimination’s damaging effects on sleep. Background: Millions of Americans have sleep...