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99,167 grants found
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Collagen Proteostasis in Health and Disease
Collagen is the most abundant protein in animals, constituting up to one-third of total protein in humans. As the major proteinaceous component of tissues ranging from bone and ski...
Convergence of behavioral and sensory information in olfactory cortex
Project Summary A key function of the nervous system is to transform sensory information from the environment into actionable percepts. In a classic hierarchical representation fra...
Engineered Cytokine-Secreting Bacteria to Treat Periodontitis.
PROJECT SUMMARY. Periodontitis is one of the most prevalent diseases and a leading cause of tooth loss. In the United States, approximately 61 million adults over 30-years old have...
Functional roles of inhibitory cerebellar outputs
Project Summary/Abstract: The precision and accuracy of vertebrate movement is mediated by the cerebellum. Cerebellar damage results in a signature motor phenotype called dysmetria...
Better Info on Women's PrEP Choices and Outcomes in Malawi
Project Summary/Abstract The goal of this study is to understand PrEP user choices, preferences, and implementation impact of the roll- out of long-acting injectable (LAI) PrEP alo...
HomeLink2: Reducing posthospitalization mortality among people living with HIV through structured home care and nutritional supplementation
PROJECT SUMMARY HIV remains the leading cause of death among adults in South Africa despite the availability of antiretroviral therapy (ART) due to failure to initiate ART and fail...
Mental and Respiratory Health Impacts of the Maui WUI Fire in Children and Adults
ABSTRACT The wildland-urban interface (WUI) fire of August 8, 2023 in Maui has been the deadliest in US history. It completely swallowed the historical town of Lahaina, claimed >...
Rejection Sensitivity and Puberty in Mental Health Vulnerability to Social Media Experiences in Early Adolescent Girls
ABSTRACT Research on the social dynamics of social media use in preteen girls is scarce, yet crucial: suicidal thoughts and depression have significantly increased among preteen gi...
A clinical-community partnership to understand health impacts of a food insecurity intervention
Project Summary Food insecurity exacts a devastating toll on U.S. families and reflects a long history of structural injustices. Experiences of food insecurity are associated with...
The oral glucocorticoid system in oral carcinogenesis and its modulation for improved treatment outcomes
PROJECT SUMMARY Oral cancer is a significant public health problem, as 58,450 new cases and 12,230 deaths occur annually. in the United States. Despite treatment advances, the over...
The SHHare Community Project: The Shared Hub for Health Action Research and Equity in Community-led Interventions
PROJECT SUMMARY/ABSTRACT Structural determinants of health are societal structures and macro-level policies that lead to key exposures, such as racial discrimination and disparate...
Advancing Proteomics Technologies for Cancer Research
Project Summary I am the Technical Director of the Proteomics and Macromolecular Crystallography Shared Resource (PMCSR) at the Herbert Irving Comprehensive Cancer Center (HICCC),...
Core A: Curation and Statistical Analysis Core
CORE A ABSTRACT Curation and Statistical Analysis Core Core Director: Kathy Panageas (MSK) The Curation and Statistical Analysis Core will be co-led by Drs. Katherine Panageas and...
Core B: Molecular Pathology and Bioinformatics Core
CORE B ABSTRACT Molecular Pathology and Bioinformatics Core Core Director: Michael Berger, PhD (MSK) The Molecular Pathology and Bioinformatics Core will work closely with all Proj...
Molecular mechanisms of progranulin as a regulator of endothelial biology and blood pressure control
ABSTRACT Endothelial cell (EC) dysfunction initiates the development of hypertension (HTN), but the mechanisms are not fully elucidated. Given that HBP is the leading cause of card...
Skin cancer on social media: Analyzing current communications, modeling diffusion potential, and developing innovative prevention-focused messages
Project Abstract Exposure to ultraviolet (UV) light between the ages of 15-20-years is the most important etiological factor in skin cancer, yet adolescents and young adults (AYAs)...
Enhancing the effectiveness of measurement-based care for youth by identifying key fidelity indicators
PROJECT SUMMARY Measurement-based care (MBC) is considered an evidence-based practice. However, low MBC fidelity (the extent to which MBC practices are delivered) in community ment...
Epigenetic drivers of quiescence in artemisinin-resistant Plasmodium falciparum malaria
PROJECT SUMMARY / ABSTRACT: Malaria, a mosquito-borne parasitic disease caused by Plasmodium falciparum (Pf), remains a significant global health threat, with ~200 million cases an...
Innate Immune Mechanisms Controlling Flavivirus Neurovirulence
Summary West Nile virus is a pathogen of global concern. Since its introduction to the US in 1999, it has caused thousands of deaths and tens of thousands of hospitalizations. West...
Functional characterization of cell surface RNA biology
PROJECT SUMMARY / ABSTRACT The composition and organization of the cell surface are critically important for cell-to-cell communication and for the ability of cells to interact wit...