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99,167 grants found
Showing 99,001 – 99,020 of 99,167 grants
Exploitation of the natural biodiversity of AAV to identify “super transducers
Project 3 - Project Summary: Liver is arguably the most permissive tissue for recombinant adeno-associated virus (rAAV)-mediated in vivo gene delivery, and liver transduction ca...
Modulation of Immune responses to gene therapy by Creation of AAV-specific Chimeric antigen receptor regulatory T cells (CAR-Tregs)
Project 4 - Abstract In Project 4, we will use our novel adeno-associated virus (AAV) directed chimeric antigen receptor (CAR) T-cells and T regulatory cells (Tregs) to modulate...
Administrative Core
PROJECT SUMMARY/ABSTRACT Administrative Core The administrative core will oversee the coordination of the Program as a whole. Specifically, it will be in charge of supervising t...
Research Bronchoscopy and Biospecimens Core
PROJECT SUMMARY/ABSTRACT Core B: Bronchoscopy and Biospecimens The goal of this core is four-fold. First, the core is responsible for performing bronchoscopy on study subjects t...
Severe Asthma Clinical Studies Core
PROJECT SUMMARY/ABSTRACT Core C The Clinical Studies Core is an integral component of the PPG as it is designed to facilitate the conduct of clinical trials outlined in the thre...
Primary Human Airway Cell Culture Core
PROJECT SUMMARY/ABSTRACT Core D Cell Culture The goal of the work described in this proposal is to collect grow, store and expand airway epithelial cells and smooth muscle cells...
Pulmonary Biostatistics Core
PROJECT SUMMARY/ABSTRACT Core E The Core will provide severe asthma investigators from each of the three Projects all facets of statistical support, including experimental desig...
S-nitrosylation signaling in asthma
PROJECT SUMMARY/ABSTRACT Project 1 Asthma afflicts over 7% of Americans and is the result of chronic inflammation of the airways leading to airway remodeling and hyperresponsive...
Airway pH regulation in asthma
PROJECT SUMMARY/ABSTRACT Project 2 The airway epithelium, like the renal tubular epithelium, expresses proteins that regulate luminal pH. For example, glutaminase regulates ammo...
Androgen signaling in asthma
PROJECT SUMMARY/ABSTRACT Asthma is a sexually dimorphic disease, with women exhibiting higher asthma prevalence and more severe manifestations than men. Projects 3 builds upon th...
Administrative Core
ADMINISTRATIVE CORE: ABSTRACT Natives Engaged in Alzheimer’s Research (NEAR) will be organized into an Administrative Core, a Recruitment and Engagement Core, a Biospecimen Core,...
Research Methods Core
RESEARCH METHODS CORE: ABSTRACT Healthy People 2020 calls for research and policy to eliminate racial and ethnic disparities in health status, health behaviors, functional limita...
Recruitment and Engagement Core
RECRUITMENT AND ENGAGEMENT CORE: ABSTRACT Many American Indian, Alaska Native (AI/AN), and Native Hawaiian and Pacific Islander (NHPI) communities view academic research with ske...
Biospecimen Core
BIOSPECIMEN CORE: ABSTRACT American Indians and Alaskan Natives (AI/ANs) and Native Hawaiians and Pacific Islanders (NHPIs) are subject to disparities in many health conditions,...
Indian Transforming Alzheimer's Care Training
RESEARCH PROJECT 1: ABSTRACT The American Indian and Alaska Native (AI/AN) population is growing 3 times faster than the US all-races population. The number of AI/ANs aged 65+ is...
IKE Kapuna (Elder Wisdom) Project
RESEARCH PROJECT 2: ABSTRACT The prevalence of Alzheimer’s disease and related dementias (ADRD) is rising in Hawai`i, where it is projected that 10% of people aged 65+ will be di...
Cognition After OSA Treatment Among Native American People
RESEARCH PROJECT 3: ABSTRACT Prevalence of obstructive sleep apnea (OSA) among older adults in the US is as high as 56%. Short-term neurological consequences of OSA include cogni...
Administrative Core
Abstract The primary goal of the Administrative Core (Core C) is to support and promote the program and data management goals of this TBRU. Amongst its responsibilities, Core C w...
Genetics & Clinical Cohorts
To achieve a 95% reduction of TB deaths by 2035 the WHO END-TB strategy states that critical introduction of new tools, such as a vaccine, drugs and treatment regimes, and a point...
Systems Biology, Bioinformatics, & Data Integration
Genome-wide research strategies provide unprecedented opportunities for insight but also major bioinformatic challenges due to the size and complexity of the data. The multidiscip...