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99,167 grants found
Showing 98,561 – 98,580 of 99,167 grants
mTOR-Mediated Desaturation of Fatty Acids in Hepatic Insulin Resistance.
Discharged members of the US Armed Services are at an increased risk of metabolic disease which is exemplified by the prevalence of type 2 diabetes mellitus (T2DM) affecting an es...
Toxicant Exposure Impacts Host-pathogen interactions within the Reproductive Tract
Project Summary Exposure to persistent environmental toxicants (such as dioxin) is a global problem, but disproportionately affects Veterans who were exposed dioxin derived from...
Defining Breath VOC Biomarkers to Improve Respiratory Health of Exposed Veterans
The goal of this resubmitted application is to define signature exhaled breath volatile organic compounds (VOCs) in veterans exposed to toxicants and to develop an effective porta...
Developing novel CRISPR/CasX editors to generate a CCR5/null immune system
The characterization of CRISPR/Cas as a method to edit genes that contribute to human diseases provides new opportunities for the development of innovative therapeutic approaches....
Foxp transcription factors in regulatory T cells
Regulatory T cells (Tregs) are critical for actively maintaining immune tolerance. The Foxp family of transcription factors is composed of four members; Foxp1, Foxp3 and Foxp4 are...
Exploring cyclic di-nucleotide signaling across the tree of life
Summary: Exploring cyclic di-nucleotide signaling across the tree of life All organisms utilize molecular regulatory mechanisms connecting external sensory systems to phenotypic...
Neural Substrates of Binge Drinking
Alcohol misuse is responsible for ~88,000 deaths annually and exerts an annual cost of ~$250 billion in the US. Binge drinking, which accounts for ~75% of these costs, is defined...
Colon cancer nanotherapy targeting STRAP
Although activation of the Ras/Raf/MEK/ERK pathway is involved in cell growth, inhibition of apoptosis, induction in stem-like phenotype, and drug resistance, little is known abou...
CMA: Network plasticity in acquired epileptogenesis
Project Summary/ Abstract: Temporal Lobe Epilepsy (TLE) is the most frequent type of post-traumatic epilepsy, causing significant morbidity in the veteran population. Approximat...
Dynamics of protein kinase CK2 signaling in prostate cancer pathogenesis
Prostate cancer (PCa) is one of the major health issues for the aging Veterans population warranting investigations to further advance knowledge of the disease pathobiology and be...
Preoptic/Hypothalamic Mechanisms of Sleep-Wake Regulation
ABSTRACT Chronic sleep disturbance is a frequent and challenging problem of human aging. In the US an estimated 39.6 million people including 8.5 million Veterans are aged 65 or...
CMA: Network plasticity in acquired epileptogenesis
Temporal lobe epilepsy (TLE) is the most common form of epilepsy in adults and a major source of disability in the veteran population as it is frequently caused by war-time head i...
Mechanism of Vascular Impairment in Neurocognitive Disorders
Vascular cognitive impairment and dementia (VCID) is the most common etiology of dementia in the elderly including veterans. Since proportion of the elderly population is progress...
Red Blood Cells shuttle beta amyloid between brain and heart: implications for the pathogenesis and the progression of Alzheimer's and Cardiomyopathy
Abstract Alzheimer disease (AD) is the most frequent form of dementia causing a significant reduction of quality of life of affected patients. In the brains of AD patients, β-amy...
A Physical Activity Intervention to Promote Cognitive Health, Cardiovascular Health and Sleep in Older Latinos
Project Summary Physical inactivity is a public health priority for older Latinos with mild cognitive impairment (MCI). MCI, considered the pre-dementia stage of Alzheimer’s dise...
A deubiquitination module controls Treg adaptation to tumor microenvironment
Project Summary: One of the recent advances in cancer treatment is the development of immunotherapy largely through targeting the checkpoint receptors. However, attempts at immun...
Establishing smoke-free homes with families involved in child protective services: An effectiveness-implementation trial of an integrated program
Project Abstract Child exposure to secondhand smoke (SHS) is linked to multiple forms of cancer throughout the lifespan. Young children living in low-socioeconomic status househo...
Translating Hyperpolarized 13C Metabolic MRI to Predict Renal Tumor Aggressiveness
Project summary: This project aims to clinically translate hyperpolarized (HP) 13C pyruvate MRI as an innovative metabolic imaging approach for noninvasive prediction of renal tu...
Next generation deep tissue quantitative optical imaging
PROJECT SUMMARY Nearly 20 years of clinical research has shown that near-infrared optical imaging based upon frequency domain diffuse optical spectroscopy (FD-DOS) can be a power...
High Resolution Mapping of Foveal Ganglion Cell Receptive Fields in the Living Primate Eye
The importance for vision of the tiny fovea has been established by centuries of investigation as well as observations of the devastating consequences of its damage through injury...