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99,167 grants found
Showing 98,381 – 98,400 of 99,167 grants
COVID-19: Understanding The Role of Corona Virus InducedDisruption Of Alveolar Type 2 Cell Function And SurfactantHomeostasis In The Pathogenesis Of COVID-19 AcuteRespiratory Distress Syndrome
ABSTRACT The Severe Acute Respiratory Syndrome (SARS)-associated coronavirus 2 (SCoV2) is the cause of COVID-19 syndrome which is marked by a refractory acute lung injury that resu...
Mechanisms and evolutionary consequences of transposon strategies to counteract host silencing
PROJECT SUMMARY Harboring active transposable elements (TEs) imposes a substantial mutational burden on the host genome. To reduce this burden, most organisms have evolved sophisti...
Motherhood Biographies and Midlife Women's Health
Abstract Research shows widening health disparities among midlife women since the mid-1980s. However, the mechanisms through which these health gradients operate are not fully know...
Identifying new drivers of ovarian cancer from the non-coding genome by converging germline risk variants and somatic mutations
PROJECT SUMMARY/ABSTRACT The goal of the proposed research training program is to provide tailored additional training to facilitate successful career development throughout the co...
Motherhood Biographies and Midlife Women's Health
Abstract Research shows widening health disparities among midlife women since the mid-1980s. However, the mechanisms through which these health gradients operate are not fully know...
The Role of the Microbiome and Notch Signaling in Esophageal Adenocarcinoma
PROJECT SUMMARY The incidence of esophageal adenocarcinoma (EAC) has risen 10-fold over the past half century and continues to have a dismal prognosis. Modeling studies suggest tha...
Improving Access and Affordability of Adult Hearing Healthcare: Effectiveness of Community-based Interventions in West Central and South Alabama
Abstract Mounting evidence suggests that hearing loss is associated with social isolation, depression and cognitive decline. Loss of hearing has become a growing public health conc...
COVID-19: Elucidating the Role of the NasalEpithelium in SARS-CoV-2 Infection, Transmission, and Prevention
ABSTRACT Severe acute respiratory syndrome coronavirus SARS-CoV-2, the causative agent of coronavirus disease 2019 (COVID-19) has led to a pandemic with a mortality of approximatel...
Investigating sex differences in DDX3X mouse models
Abstract De novo mutations in the RNA binding protein DDX3X result in DDX3X syndrome. DDX3X mutations are also associated with autism spectrum disorder (ASD) and may account for 1-...
Molecular mechanistic studies of long “noncoding” RNAs in mammalian cell differentiation
Project Summary/Abstract The goal of this application is to obtain funding for purchasing the Jess System from the ProteinSimple for automatic and quantitative protein analysis. Th...
Examining the role of the neighborhood environment on muscle function in older adults
PROJECT SUMMARY/ABSTRACT Poor muscle function is a pressing public health problem: half of all U.S. older adults meet criteria for muscle weakness. Poor muscle function, defined by...
UNDERSTANDING THE MECHANISMS UNDERLAYING R-LOOP BIOGENESIS AND RESOLUTION IN MAMMALS
Project summary During transcription, the nascent RNA can anneal with the template DNA strand behind the advancing RNA polymerase and cause the formation of alternative DNA structu...
Dynamics, Regulation and Function of p53 in Single Cells
Project Summary The dynamics of signaling systems are critical for controlling gene expression programs and cellular outcomes. The tumor suppressor protein p53 is a transcription f...
Administrative Supplement to Development of high-throughput, high-sensitivity EPR sample handling capabilities for biomedical research
Project Summary/Abstract Electron paramagnetic resonance (EPR) spectroscopy is a critically important technique in biomedical research with a unique ability to detect naturally occ...
Ultraviolet Photodissociation Mass Spectrometry for Characterization of Biological Molecules
Abstract. Understanding the functions of lipids, proteins and even larger macromolecular assemblies depends on deciphering complex structures of individual molecules as well as dec...
Novel Nutrient Functions and Sensing Mechanisms
Project Summary In our original proposal for the R35 grant application, we described the two major goals of the research in the field of nutrient function and sensing. One is to di...
Assessing the Influence of the Human Lipidome on Risk of Diabetes in a Minority Population
PROJECT SUMMARY Type 2 diabetes is a major public health concern. Diabetes currently affects 25.8 million people in the US alone and 90-95% of all cases are type 2. There are many...
lluminating the biochemistry of zinc and RNA in live cells
Project Summary Zinc (Zn2+) is the second most abundant transition metal in mammals after iron. There are over two thousand proteins encoded by the human genome that contain zinc b...
Genome-wide structure-based analysis of protein-protein interactions and networks
Project Summary Our lab works in the general area of computational structural biology although it also includes an experimental component. We carry out theoretical and computationa...
The functions of the zinc finger protein ZPR1 in R-loop metabolism and neurodegeneration.
PROJECT SUMMARY The goal of this study is to examine the functions of the zinc finger protein ZPR1 in R-loops metabolism and neurodegeneration. R-loops are formed during transcript...