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99,167 grants found
Showing 98,181 – 98,200 of 99,167 grants
Controlling Catheter-Associated Urinary Tract Infections Using Smart Catheters with Rationally Designed Active Topographies
Catheter associated urinary tract infection (CAUTI) is one of the most common healthcare-associated infections (HAIs), with a prevalence of 13 – 15% in the United States. CAUTIs a...
Lactoferrin and lysozyme to promote nutritional, clinical, and enteric recovery: A factorial placebo-controlled randomized trial among children with diarrhea and malnutrition
PROJECT SUMMARY/ABSTRACT Diarrhea kills more than half a million children each year and is the third largest contributor to lost disability adjusted life years. While rehydratio...
Understanding Myocardial Recovery in Diabetes and Heart Failure
Diabetes Mellitus (DM) is a global epidemic and its prevalence among US veterans is higher than the civilian population. Heart failure (HF) is the leading cause of death in diabet...
Structural and Functional Studies of HER Receptors
PROJECT SUMMARY/ABSTRACT Receptor tyrosine kinases (RTKs) are activated by extracellular ligands to transduce the bulk of the signals that control cellular growth, proliferation...
The role of the proximal nephron in salt-sensitive hypertension
The dramatic rise in U.S. fructose consumption mirrors the increase in the incidence of hypertension. More than 17 million Americans consume >20% of their calories as fructose and...
Regulation of the neuroinflammatory response in autoimmune uveitis
Research Abstract: Autoimmune uveitis is a serious sight-threatening condition defined by an autoreactive immune response against the retina and uveal tissues. In autoimmune uveit...
Development of high-throughput, high-sensitivity EPR sample handling capabilities for biomedical research
Project Summary/Abstract Electron paramagnetic resonance (EPR) spectroscopy is a critically important technique in biomedical research with a unique ability to detect naturally o...
Noninvasive measurement of oxygenation using quantitative susceptibility mapping (supplement)
PROJECT SUMMARY/ABSTRACT The goal of this research is to develop and validate cardiac quantitative susceptibility mapping (QSM) for the assessment of mitral annular calcification...
The PreVAIL-kIds Common Protocol
Abstract PreVAIL-kIds sites have iden5fied opportuni5es to rapidly acquire and share samples and clinical data among themselves, thus catalyzing the process of mul5-site valida5on...
Molecular mechanisms of exocytotic vesicle fusion and release.
Fusion of membrane bound vesicles with a target membrane is of ubiquitous importance for cellular function from intracellular trafficking to exocytotic release of various mediator...
Sensorimotor Learning Through Adjustments of Cortical Dynamics
Abstract Extensive research spanning theory, psychophysics, and physiology has investigated how we rely on statistical regularities in the environment to improve our sensorimotor...
Nociceptor neuron regulation of gastrointestinal barrier protection and host defense
PROJECT SUMMARY Nociceptor neurons are peripheral sensory neurons that densely innervate the gastrointestinal tract, detecting noxious/harmful stimuli to mediate protective neura...
ERβ repurposes EZH2 to suppress oncogenic NFκB signaling in TNBC
PROJECT SUMMARY/ABSTRACT Breast cancer remains the most commonly diagnosed cancer in women and is the second leading cause of cancer-related deaths among women. Triple Negative B...
Novel strategies to understand, predict, and prevent vascular toxicity of targeted CML therapies
Molecularly targeted cancer therapies, such as Abl-targeted tyrosine kinase inhibitors (TKIs), have converting many terminal cancers, including chronic myeloid leukemia (CML), int...
Elucidating mechanisms for enhanced anaerobic bioremediation in the presence of carbonaceous materials using an integrated material science and molecular microbial ecology approach
PROJECT SUMMARY: Halogenated compounds, including legacy pollutants (e.g., chlorinated ethenes (CEs), polychlorinated biphenyls) and emerging contaminants (e.g., 1,2,3-trichloropr...
Mechanistic analysis and allellic genome editing of iPSC-derived dominant LCA model
PROJECT SUMMARY Leber congenital amaurosis (LCA) is a group of devastating early-onset retinal dystrophies affecting roughly 1/50,000 to 1/33,000 newborns. LCA-associated varian...
Structure and Function of Primate Retinal Circuits
An understanding of the normal structure and function of the retina is important to appreciate changes that occur during disease, development and aging. To this end, a longstandin...
Mitochondrial pyruvate transport in retinal health and disease
PROJECT SUMMARY/ABSTRACT The retina is the most metabolically active neuronal tissue in the human body. The defect in the energy metabolism of photoreceptor neurons and their sup...
Accounting for Hidden Bias in Vaccine Studies: A Negative Control Framework
Project Summary / Abstract The proposed research aims to develop novel causal inference methods to resolve unmeasured confounding bias known to plague vaccine effectiveness and s...
Cortical circuit mechanisms of visual shape processing
PROJECT SUMMARY Humans and other primates rely on using visual shape information to identify and interact with objects in the world. The goal of this project is to gain mechanist...