Browse All Grants
99,167 grants found
Showing 96,621 – 96,640 of 99,167 grants
Analysis of functional genetic variants in RNA processing and expression
Project Summary The goal of this project is to functionally annotate genetic variants in post-transcriptional regulation of RNA expression, which extends and complements the curren...
Capacity limits in the neural circuitry of visual word recognition
Project Summary / Abstract For most literate adults, reading feels effortless. However, visual word recognition is a complex process performed by specialized circuits in the brain,...
ENCODE Mapping Center-A Comprehensive Catalog of DNase I Hypersensitive Sites
ABSTRACT The overall mission of this Mapping Center is to create and disseminate open access, comprehensive, high-quality, high-resolution reference maps of...
Regulation of Ku70 methylation and functions by SETD4
Regulation of Ku70 Methylation and Functions by SETD4 (Abstract) The objective of this study is to elucidate a novel regulatory mechanism of Ku70 functions that are controlled by l...
Spatial and nonspatial knowledge
Project Summary The ability to navigate from one place to another is essential for a flourishing and autonomous human life. Cognitive scientists have long believed that navigation...
Cognitive training to reduce incidence of cognitive impairment in older adults
PROJECT SUMMARY Dementia is the most expensive medical condition in the US. There is an urgent need to intervene to curb the increasing prevalence of dementia in our population. St...
Merging machine learning and mechanistic models to improve prediction and inference in emerging epidemics
PROJECT SUMMARY When an outbreak of an established or emerging infectious disease occurs we ask a standard set of questions that are critical to a lifesaving public health response...
Targeting MUC5AC mucin in breast cancer brain metastasis
Abstract Breast cancer (BC) brain/central nervous system (CNS) metastasis is associated with poor survival among U.S. women, with 30-40% of these cases reported as triple receptor-...
The role of obscurin and Obsl1 as key determinants for diastolic function
Project Summary: The role of obscurin and Obsl1 as key determinants for diastolic function Cardiovascular disease (CVD) remains a leading cause of mortality in the US, with heart f...
Gender-based differences in non-HIV STI testing among sexually active transgender and nonbinary persons: Bridging gaps in STI research
PROJECT ABSTRACT Research suggests that transgender (trans) populations, a diverse group of persons whose gender identity and/or expression differ from societal expectations associ...
Commensal control of C. difficile virulence
Abstract: Clostridioides difficile, the etiology of pseudomembranous colitis, causes substantive morbidity, mortality and close to $5 billion/year in US healthcare costs. Commensal...
Studies of Allostery between Multi-domain Proteins and Nucleic Acid Complexes
Project Summary The PI Batista from Yale and co-investigators (Lisi, Brown University, and Palermo, UC Riverside) will investigate allosteric pathways in the CRISPR-Cas9 system – c...
Imaging brain iron and protein aggregation with MRI for assessing Alzheimer's disease pathology and progression
Abstract Alzheimer’s disease (AD) affects over 5 million Americans and is expected to affect 2-3-fold more in the next few decades. AD is associated with aggregation of amyloid-bet...
Linkage of s100a10 (p11) to enteric 5-HT4-mediated serotonergic signaling roles in GI motility, enteric nervous system development, and co-morbid dysfunction of gut and brain
Project Summary Although functional gastrointestinal (GI) disorders (FGIDs) are the most common causes of bowel dysfunction worldwide, many patients are inadequately treated becaus...
SMART NANPs: new molecular platform for communication with human immune system and modulation of therapeutic responses
Principal Investigator/Program Director (Last, First, Middle): Afonin, Kirill, A PROJECT SUMMARY What if healthcare providers were equipped with biocompatible, biodegradable, robus...
Mesenchymal modulation of epithelial metaplasia in lung fibrosis
Project Summary/Abstract Aberrant epithelial reprogramming can take the form of metaplasia, characterized by the appearance of mature cell types that are not normally present at th...
Bio-tribo-corrosion resistant 3D Printed Composites for Load-bearing Implants
Among load-bearing implants, total hip arthroplasty (THA) is probably the most clinically successful intervention. CoCrMo alloy, a wear resistant material of choice, is typically u...
Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients
7. Project Summary/Abstract Gliomas are rarely curable tumors with a low survival rate of 36% at five-years that is well below the average survival rate of 67.2% across all cancers...
Elucidating the Temporal, Spatial and Cellular Effects of Differential APOE Isoform Expression
Project Summary Carriers of the apolipoprotein E (APOE) ε4 gene are at a significantly increased risk for developing Alzheimer’s disease (AD). Although numerous theories have been...
High-sensitivity Immunomagnetic System for "Liquid Biopsy" of Alzheimer's Disease
Project Summary Alzheimer’s disease (AD) is a major healthcare and social-economic burden. With effective treatment yet to be developed, the early detection at the prodromal stage...