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99,167 grants found
Showing 96,481 – 96,500 of 99,167 grants
Elucidating the causal associations underlying Alzheimer's disease
Project Summary Alzheimer’s disease (AD) is a global crisis facing the aging population and society as a whole. With the number of people living with AD predicted to rise dramatica...
Unraveling the role of HLA-B51/ERAP1 in Behcet's eye disease
ABSTRACT / PROJECT SUMMARYHLA-B*51 in epistasis with the ERAP1 haplotype Hap10 confers the strongest currently known risk for Behcet’s Disease (BD) and Behcet’s Eye Disease (BED),...
Gene Expression Regulatory Pathways and Retinal Ganglion Cell Neuroprotection
Loss of retinal ganglion cells (RGCs) in glaucoma and traumatic and other optic neuropathies results in permanent partial or complete blindness. Molecular mechanisms that may oppos...
Circuits Driving Spatial Coding Deficits in Epilepsy
Project Summary/Abstract Temporal lobe epilepsy (TLE) is a debilitating disorder that includes pervasive memory impairments that significantly impact quality of life. In rodent mod...
Evaluating the role of P53 pathways in malaria
Project Summary/Abstract Malaria caused by the Plasmodium parasite remains a global health threat, affecting ~200 million people and leading to more than 400,000 deaths per year. U...
The role of TNFR2 in ameliorating progressive encephalomyelitis
The mechanisms driving progressive multiple sclerosis (MS) remain enigmatic. Progression of MS correlates with the expression of the cytokine tumor necrosis factor (TNF) in cerebro...
Merging machine learning and mechanistic models to improve prediction and inference in emerging epidemics
PROJECT SUMMARY When an outbreak of an established or emerging infectious disease occurs we ask a standard set of questions that are critical to a lifesaving public health response...
Understanding the sequence and structural determinants of phase behavior of ALS-causing proteins
Summary Amyotrophic lateral sclerosis (ALS) is a life-threatening, neurodegenerative disease that causes the degeneration of motor neurons in the brain and spinal cord. There are c...
Muller cell activation and remodeling in AMD.
Age-related macular degeneration (AMD) is a complex, multifactorial disease. I have recently reported subretinal Müller cell membranes in areas of geographic atrophy (GA). These me...
Contra-Thermodynamic Catalysis and Fluorine Sculpting; Two Counter Cultural Approaches to Synthesis
Project Summary/Abstract The objectives of this proposal are two-fold and include the development and conceptual advancement of contra-thermodynamic catalysis and fluorine sculptin...
Effects of aging on signal in noise processing
PROJECT SUMMARY/ABSTRACTAge-related hearing loss is a ubiquitous problem, estimated to affect up to one third of the population. This condition is much more detrimental than ‘hard...
Nuclear Organization and Function
PROJECT SUMMARY. Proper regulation of gene expression is essential for cell differentiation and homeostasis. Most of our understanding of the mechanisms that control the transcript...
Reactivity-Activation of O(2) or NO in Copper and Heme-Cu Coordination Complexes
Project Summary Proposed investigations derive from two on-going R01 GM research programs. The study objectives include the design, synthesis & investigation of synthetic model...
Unlocking sequence-structure-function-disease relationships in large protein super-families
Project Summary Predicting disease phenotypes from genotypes is a grand challenge in biology and personalized medicine. Our long-term goal is to address this challenge using a comb...
Neuronal Mechanisms of Metabolic and Genetic Defects of the Peroxisome
PROJECT SUMMARY Peroxisomes are fundamental sub-cellular organelles present in all eukaryotic cells. Peroxisomes participate in a number of biochemical pathways including catabolis...
Development of a rapid, pan fungal diagnostic assay
ABSTRACT Diagnosing fungal infections faces a number of challenges including a decline in expertise needed for identifying fungi and a reduced number of instruments and assays spec...
Neutralizing the degenerate disc microenvironment to enhance the efficacy of therapeutic stem cells
Abstract Low back pain is the leading cause of disability in the United States, with an estimated socioeconomic cost exceeding $100 billion each year. Intervertebral disc degenerat...
Methods for Evolutionary Genomics Analysis
Summary/Abstract Continuing advances in nucleotide sequencing have resulted in the assembly of datasets containing large numbers of species, genes, and genomic segments. Phylogenom...
Elucidating the Temporal, Spatial and Cellular Effects of Differential APOE Isoform Expression
Project Summary Carriers of the apolipoprotein E (APOE) ε4 gene are at a significantly increased risk for developing Alzheimer’s disease (AD). Although numerous theories have been...
Transcriptional Regulation of Lung Alveolar Regeneration
ABSTRACT The respiratory system is comprised of multiple unique and spatially distinct compartments that respond to injury and diseases states differently based on their cellular a...