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Central Regulation of Sodium Appetite via Synergistic Action of RAAS-sensitive Neurons
PROJECT SUMMARY The motivation to consume sodium, often referred to as "sodium (or salt) appetite", is a hard-wired neural response to sodium deficiency regulated by the...
A Dental implant registry of treatment outcomes of implant therapy by practitioners in the National Dental Practice Based Research Network
There is a substantial body of literature to support that biological and prosthetic complications occur which mayinterfere with the health of the peri-implant tissues, the function...
Personalized protein-protein interactomes and precision medicine in pulmonary arterial hypertension
Project Summary/Abstract Pulmonary arterial hypertension (PAH) is a highly morbid cardiopulmonary disease characterized by an obliterative vasculopathy involving distal pulmonary a...
Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)
Latinos have up to a fourfold risk of Alzheimer's disease and related dementias (ADRD) compared to non- Hispanic whites. Further, ADRD onset occurs earlier in Latinos and is o...
Imaging brain iron and protein aggregation with MRI for assessing Alzheimer's disease pathology and progression
Abstract Alzheimer’s disease (AD) affects over 5 million Americans and is expected to affect 2-3-fold more in the next few decades. AD is associated with aggregation of amyloid-bet...
Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS)
Exposure to repetitive head impacts (RHI) through participation in contact and collision sports (CCS) can result in symptomatic concussions and asymptomatic subconcussions and may...
Methods for Evolutionary Genomics Analysis
Summary/Abstract Continuing advances in nucleotide sequencing have resulted in the assembly of datasets containing large numbers of species, genes, and genomic segments. Phylogenom...
Exploiting Unconventional Building Blocks in Chemical Synthesis
Project Summary/Abstract The central objective of this application is to harness unconventional synthetic building blocks for the development of new, reliable, and efficient, metho...
Mitotic transmission of acentric chromosome fragments
The goal of this proposal is to elucidate the molecular and cellular basis of a newly discovered diverse set of adaptive mechanisms that maintain the integrity of the genome during...
Glutamatergic basal forebrain neurons in aversion-resistant drinking
Project Summary A hallmark of alcohol use disorder is continued seeking and consumption of alcohol despite negative consequences. Neuroadaptations in corticostriatal projections to...
Chemoenzymatic glycan editing for deciphering biological functions of glycans
PROJECT SUMMARY/ABSTRACT Cell-surface glycans participate in numerous biological processes, including signal transduction, cell-cell communication and development. Aberrant glycosy...
Harnessing Glycoproteomics and Glycomics to Understand Cardiac Biology and Disease
ABSTRACT Our research program develops and applies innovative mass spectrometry technologies, bioinformatics tools, and methodologies to transform our understanding of cell surface...
Targeting vulnerabilities of PPM1D-mutant gliomas
Project Summary/Abstract Diffuse midline gliomas (DMGs) are devastating brain tumors of childhood with no curative treatments. We and others have observed up to 15% of all DMGs to...
Targeting Integrins in Lung Cancer
Lung cancer is the most common cause of cancer-related deaths in US veterans and worldwide. Molecularly targeted therapy and immunotherapy are two recent major breakthroughs in lun...
Novel regulators of Slo2 potassium channels
Abstract The focus of research in my lab is to determine how physiological functions of Slo2 channels are regulated by other proteins. Slo2 channels are a family of large-conductan...
Energy Balance, mTOR pathway signaling, and breast cancer prognosis
Project Summary/Abstract The objective of this project is to understand the role of the mechanistic Target of Rapamycin (mTOR) pathway in the association between energy imbalance a...
Impact of Loss-of-function NADPH Oxidase Variants on B cell Activation in SLE
Project abstract Genome-wide association studies (GWAS) have identified immune pathways linked to the pathogenesis of systemic lupus erythematosus (SLE). However, despite these ins...
Bayesian Network-Based Integrative Genomics Methods for Precision Medicine
Project Summary/Abstract Modern multi-platform genomic data sets contain substantial molecular information potentially useful for discovering new precision therapeutic strategies....
Continuous Therapeutic Drug Monitoring of Antibiotics in CRRT
Summary Aptamers are oligonucleotide-based receptors that can be isolated from the large libraries of random oligonucleotides to bind to small molecules. In the past, our team deve...
Glioma therapy with oncolytic adenoviruses and immunometabolic adjuvants
SUMMARY / ABSTRACT With current treatment options, the five-year survival rate of patients with glioblastoma (GBM) is only 5%. Oncolytic viruses are promising treatments against so...