Sleep in Neurocognitive Aging and Alzheimers Research (SANAR)

Latinos have up to a fourfold risk of Alzheimer's disease and related dementias (ADRD) compared to non- Hispanic whites. Further, ADRD onset occurs earlier in Latinos and is often accompanied by vascular risk factors. Consistent with the NIA Alzheimer's prevention Initiative, we will focus on two vascular risk factors never studied

in Latino ADRD prevention studies: obstructive sleep apnea (OSA) and non-dipping of blood pressure (NDBP). Over the last decade, OSA has been shown to increase mortality, stroke and vascular disease (e.g. NDBP). OSA is also linked with a 26% increase in cognitive decline or ADRD. However, most studies are limited by the

use of self-reported data, measured OSA at a single time point or studied older adults, which do not preclude the possibility of reverse causation. Our published data from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL; N≈16,000 at Visit-1), shows that OSA is associated with worse cognitive function,

especially in females