Browse All Grants
99,167 grants found
Showing 901 – 920 of 99,167 grants
Relationships between immunosenescence, brain aging biomarkers, and cognition across nonhuman primate species of differing lifespans
Project Summary The world’s population is aging, which brings about huge scientific challenges. Since the biological process of aging is by far the greatest risk factor for most ch...
Improving causal inference in Alzheimer's Disease prevention research on modifiable risk factors: the Triangulation of Innovative Methods to EndAD (TIME-AD) project
OVERALL COMPONENT PROJECT SUMMARY Research on Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD) has identified several promising risk factors which could guid...
Core A: Administrative Core
ADMINISTRATIVE CORE SUMMARY The Administrative Core will administer and lead the P01, including the other four Cores and the four Projects. The Administrative Core is led by TIME-A...
Core B: Analytics Core
ANALYTICS CORE SUMMARY The Analytics Core will support all four research components of the TIME-AD program, ensuring coordinated statistical approaches and principled decisions on...
Equity and Dissemination Core
EQUITY AND DISSEMINATION CORE SUMMARY The purpose of the Equity and Dissemination (E&D) Core is to maximize the impact of the Improving causal inference in AD projects for prev...
Core D: Cognition, Exposure, and Covariates (CEC) Data Core
COGNITION, EXPOSURE, AND COVARIATES DATA CORE SUMMARY The TIME-AD project will use multiple data sources to enhance understanding of how AD/ADRD risk is affected by four high prior...
Core E: Genetic and Policy Data Core
GENETIC AND POLICY DATA CORE SUMMARY TIME-AD will be supported by a specialized Genetics and Policy Data (GPD) Core focusing on causal identification based on quasi-experimental so...
Project 1: Alcohol use and AD/ADRD risk: innovative methods and data for new insights
PROJECT SUMMARY The effects of alcohol use on Alzheimer’s Disease and Alzheimer’s Disease Related Disorders (AD/ADRD) remain uncertain. Long hypothesized to have a J-shaped relatio...
Project 2: Depression and chronic pain: Modifiable targets for prevention of AD/ADRD
Summary/Abstract Depression is a highly prevalent and modifiable risk factor for Alzheimer’s Disease and Alzheimer’s Disease Related Disorders (AD/ADRD). Severe and untreated depre...
Project 3: Prevention and Treatment of Hearing and Vision Impairments for Reducing AD/ADRD risk
PROJECT SUMMARY/ABSTRACT Sensory impairments, including hearing and vision loss, affect up to 40% of older adults and have been linked to higher risk of Alzheimer’s disease and Alz...
Project 4: Social isolation as a driver of AD/ADRD incidence and disparities
PROJECT SUMMARY Social isolation, defined as an objective state of limited to no social contact, impacts millions of older adults, with prevalence estimates varying from 10-25% acr...
Mechanisms Underlying Heterogeneity of Cognitive Outcomes in Synucleinopathy
OVERALL ABSTRACT/SUMMARY The mission of this Penn PO1 Center on “Mechanisms underlying heterogeneity of cognitive outcome in synucleinopathy” is to understand why the same underlyi...
Core A: Administrative Core
ADMINISTRATIVE CORE SUMMARY/ABSTRACT The Administrative Core of the proposed NIA PO1 Center at the University of Pennsylvania (Penn) Perelman School of Medicine (PSOM) is key to ac...
Core B: Clinical Core
PROJECT SUMMARY/ABSTRACT (CLINICAL CORE) The Clinical Core of the proposed NIA P01 at the University of Pennsylvania (UPenn) Perelman School of Medicine will be crucial to accompli...
Core C: Resource Core
Resource Core: Abstract Nearly all neurodegenerative disorders are characterized by progressive accumulations of pathological deposits of disease protein aggregates within cells, b...
Core D: Data Management and Statistics Core
Data Management and Statistics Core Core Leader: Sharon X. Xie; Co-Investigator: Corey McMillan Summary/Abstract: Data Management and Statistics Core The Data Management and Statis...
Project I: Alpha Synucleinopathy in the Human Brain Connectome
PROJECT I: ABSTRACT The overall objective of this project is to develop predictive models of alpha-synuclein (aSyn) propagation in the human brain in Lewy body dementia (LBD) patie...
Project II: Deciphering the Signatures of Pathological Changes on Alpha-Synuclein
PROJECT II: Summary/Abstract Pathological alpha-Synuclein (aSyn) accumulates in neurons as Lewy bodies (LBs) and Lewy neurites (LNs) in Lewy body diseases (LBD) including dementia...
Project III: Heterogeneity of Outcomes in Synucleinopathies: Insights from Genomics and Proteomics
PROJECT III SUMMARY/ABSTRACT Heterogeneity of Outcomes in Synucleinopathies: Insights from Genomics and Proteomics While patients with Lewy body disorders (LBD) share the core feat...
Project IV: In Vivo Dissection of Genetic Modifiers on Different Stages of Synucleinopathy
PROJECT SUMMARY Project IV: In Vivo Dissection of Genetic Modifiers on Different Stages of Synucleinopathy Lewy body diseases (LBDs) are defined by the presence of intraneuronal in...