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99,167 grants found
Showing 621 – 640 of 99,167 grants
Evaluating the Impact of Non-COPD Medications on COPD Management
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality worldwide. While numerous scientific advances have been made to improve the care of patie...
Miniature Selective Plane Illumination Fluorescence Microscope for High-resolution Volumetric Imaging in Freely Behaving Mice
An important theme in system neuroscience is to understand the fundamental principle by which brain cells work together to give rise to behaviors. Neuroscience experiments often re...
Dementia and the opioid epidemic: The impact of the 2016 CDC guidelines on disparities in pain management
PROJECT SUMMARY/ABSTRACT The research proposed in this application aims to study the impact of the publication of the 2016 Centers for Disease Control and Prevention (CDC) analgesi...
Sleep pathology and cardiac aging
PROJECT SUMMARY/ABSTRACT Sleep is normally a period of biological rest and recuperation for the cardiovascular system. Inadequate or low- quality sleep is known to increase the ris...
Optimizing the Daily Care Interactions Between Direct Care Staff and Assisted Living Residents with Dementia
PROJECT SUMMARY About 25% of daily care interactions between staff and residents in long-term care including Assisted Living Facilities (ALFs) comprise of poor care interactions. I...
Illuminating associations between parent's adverse childhood experiences, children's obesity, and neighborhood environment
SUMMARY Adverse childhood experiences (ACEs) can increase the risk for obesity both during childhood and later in adulthood. Emerging evidence suggests a parent's history of A...
Sexual health behaviors among US adolescents and young adults
ABSTRACT Rough sexual behaviors (i.e., sex that involves slapping, hard spanking, punching, choking, and/or other physically aggressive acts) appear to be increasingly common among...
Spatially resolved multi-omics sequencing of FFPE tissues at cellular level
Project Summary Studying tumors in a spatial context will advance our understanding of intratumoral heterogeneity and how the complex interactions between cancer and surrounding no...
Astrocytes as the integrators of neuromodulator signals
This transformative award application is designed to test an integrative hypothesis about astrocyte function across the brain while extending the current limits of state-of-the-art...
Synergistic advancements in MR thermometry and predictive thermal modeling towards improved characterization of human brain temperature
Project Summary Brain temperature regulation is crucial for neurologic function and recovery after ischemia and injury. Local brain temperature increases as small as 1-2°C signific...
Advancing Visualization and Quantification of Subcellular and Biomolecular Mechanics through Mechanochemical Protocols
Project Summary Exploring cellular mechanics represents a groundbreaking frontier to unravel the complexities of life and disease. Far from being static entities, cells are dynamic...
Cranial Osteopathic Manipulative Medicine Enhances Brain Fluid Flow Alleviating Neuroinflammation
PROJECT SUMMARY/ABSTRACT Osteopathic manipulative medicine (OMM) has been used clinically to improve the quality of life for several medical conditions and injuries; however, limit...
Effectiveness of a Multilevel Rural Community Engagement Model for Improving Childrens Dietary Intake in Family Child Care Homes
PROJECT SUMMARY/ABSTRACT Early childhood is a formative period for establishing healthy dietary habits and weight trajectories, as such habits and weight predict later health outco...
Quantitative Ultrasound for Interstitial Lung Diseases
ABSTRACT The objective is to demonstrate feasibility of LQUS in human patients for assessing the severity of pulmonary edema due to heart failure and of idiopathic pulmonary fibros...
Pathways to Resilience of Social Networks of Older Adults with Advanced Cancer
Our study will address the goals of RFA-AG-24-025 by elucidating how the pathways by which key aspects of social connectedness in social networks (SNs)—structural characteristics,...
Pulsed laser therapy in an asymptomatic head injury-accelerated Alzheimer's model
Abstract Traumatic brain injury (TBI) is a significant cause of death and disability in the US. The true extent of TBI may be underestimated, with many cases of asymptomatic TBI go...
Developing a foundation for a novel emergency department-based intervention to address inappropriate aspirin
PROJECT SUMMARY/ ABSTRACT Aspirin is one of the most used drugs in the world. Unfortunately, many older adults will consume aspirin without an established indication, a scenario in...
Cell Death Regulation by Pro-Apoptotic BOK in Tauopathies
PROJECT SUMMARY Alzheimer's disease (AD), and other neurodegenerative tauopathies, are defined by their pathologic accumulation of overexpressed, hyperphosphorylated, and olig...
Deep integrative analysis of Hi-C data
Project Summary/Abstract Chromatin 3D structure plays an important role in fundamental genomics processes. A variety of experimental methods, such as Hi-C, GAM, SPRITE, and HiChIP,...
Improving hand kinematic predictions from implanted EMG in humans and monkeys
Project Summary There are millions of people worldwide with debilitating upper limb amputations. While electrical signals from residual muscle can provide some function, every ampu...