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99,167 grants found
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SEMI-SIMOA: A Chip-scale Flow-based Single-Molecule Assay at the Point-of-Care using Semiconductor Technology
Project Summary Over the past two decades, single-molecule assays (SIMOA) have transformed the detection landscape for low- abundance protein biomarkers, such as cytokines and neur...
Molecular Mechanisms and Heterogeneity in the Inferior Olivary Nucleus Development
SUMMARY Despite the apparent uniform cytoarchitecture of the cerebellar cortex, imaging studies have revealed discrete functional domains within it. We have recently identified num...
Recognition and Ubiqutination of neurodevelopmental chromatin regulators
PROJECT SUMMARY The objective of this proposal is to illuminate the fundamental mechanisms by which ubiquitin ligases recognize and ubiquitinate substrates within protein complexes...
Methods and tools to integrate multi-omics datasets to understand preclinical autoimmune and immune-mediated diseases
ABSTRACT Autoimmune or immune-mediated diseases affect 10% of the world population, and most conditions have no cure. Existing treatment options are often broadly acting and have n...
Optical Sensing of the Spread of Alpha-Synuclein Aggregates in Models of Parkinson's Disease and Related Dementias
The basis for the onset and progression of Parkinson's disease (PD) and related dementias remains unknown, but the formation and spread of aggregates of the protein alpha-synu...
Statistical Methods for Identification and Evaluation of Predictive Biomarkers in Cancer
Project Summary Relapsed/refractory cancer is a principal cause of cancer-related death. Targeted therapies, which represent a new generation of cancer therapies, have advanced the...
Bacterial stress responses and surface adhesion in shear flow
Project Summary My research group combines traditional molecular biology approaches with microfluidic technology to examine how host-relevant shear flow impacts stress responses an...
Development of a PET CCR2 Imaging Agent to Profile PDAC Microenvironment
Project Summary Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer. PDAC is the 4th leading cause of cancer related death with a 5-year survival rate
Quantifying the effect of biomechanical SUID risk factors on infant respiration
PROJECT SUMMARY The leading cause of mortality for infants from 1–12 months is sudden unexpected infant death (SUID), encompassing both suffocation-related deaths and sudden infant...
Gastrointestinal Dysfunction in Down Syndrome
PROJECT SUMMARY Down syndrome (DS), or Trisomy 21, is the most frequent chromosomal abnormality in humans, resulting from a complete or partial extra copy of chromosome 21. Clinica...
Molecular mechanisms governing chikungunya virus binding, tropism, and pathogenesis
Chikungunya virus (CHIKV) is an arthritogenic alphavirus that causes a painful musculoskeletal inflammatory disease, which can persist for months to years. Chronic CHIKV arthritis...
Integration of CSF Proteogenomics in the Diagnosis and Management of Diffuse Gliomas
Project Summary Diffuse gliomas are the most common primary malignant adult brain tumor. Lower grade gliomas (Grade 2) inevitably become malignant, and prognosis is fatal. Key clin...
Deciphering mechanisms of transcriptional repression which drive midline glioma
PROJECT ABSTRACT: Diffuse midline glioma (DMG) is a universally lethal form of brain cancer that affects both children and adults, with most patients passing away within 1-year of...
Nurse and Peer Led Suicide Prevention in Tajikistan
Abstract This R34 application responds to RFA-MH-23-260 by adapting and piloting a novel intervention for suicide prevention in primary care for women at moderate or high risk for...
Use of specific JAK inhibition on inflammatory skin and scalp diseases in Down syndrome
Project Summary Down syndrome (DS) affects 1 in 700 newborns in the United States. It is the most common genetic cause of intellectual disability. DS individuals also frequently pr...
Epigenetic and metabolic bottlenecks of tumorigenesis
Recurrent metastasis is the leading cause of breast cancer mortality. Dormancy is a critical, but poorly understood, step in the tumorigenic process where breast cancer cells can r...
Reducing the risk of chronic hypertension and improving vascular function following preeclampsia
Project Abstract/Summary Hypertensive disorder of pregnancy (HDP) is a major public health problem especially postpartum. Postpartum hypertension (HTN) accounts for nearly 75% of m...
Neural bases of masked amplitude-modulation perception
The proposed project uses behavioral and neurophysiological experiments in an animal model to explore mechanisms underlying the “modulation filterbank” of human perceptual studies....
IAP inhibition as a therapeutic strategy to target therapy-resistant leukemia initiating cells
Acute myeloid leukemia (AML) is a devastating malignancy with dismal outcomes for patients, particularly in the elderly where most cases occur. The recent approval of the BCL2 inhi...
Untangling dopamine and glutamate neuron function in the VTA
Project Summary / Abstract Ventral tegmental area (VTA) dopamine neurons are essential for associative learning of reward and aversion- related cues, updating learned associations...