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99,167 grants found
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Transcatheter vs. Surgical Treatment of Degenerative Mitral Regurgitation: A Comparative Study of Clinical Outcomes, Patient Experiences, and Mechanistic Insights with Multimodality Imaging
PROJECT SUMMARY Degenerative mitral regurgitation (DMR) impacts approximately 3% of the general population and 10% of adults older than 75-years. Its treatment has significantly ev...
Single-cell RNA-sequencing for functional analysis of monocytes and macrophages in periodontitis
PROJECT SUMMARY Periodontitis is a common, chronic, inflammatory disease, triggered by subgingival microbial agents, which can lead to tooth loss and contribute to systemic inflamm...
Nociplastic mechanisms in temporomandibular disorders: Separating nociception from pain
Project Summary: Quantitative sensory testing (QST) is widely used to make inferences about pain processing mechanisms, including how processing is disrupted in chronic pain. Howev...
Combination Therapies Targeting Insulin Signaling in Endometrial Cancer
PROJECT SUMMARY/ABSTRACT Endometrial cancer is the most common gynecologic malignancy in the developed world, and its incidence and mortality rate are increasing due, in part, to t...
Rac guanine nucleotide exchange factors in lung cancer
ABSTRACTKRAS and EGFR mutations are the most prevalent genetic alterations detected in human lung adenocarcinomas, and play essential roles in malignant transformation and disease...
C2 domain therapeutics for muscular dystrophy
Mutations in the dysferlin gene (DYSF) cause Limb Girdle Muscular Dystrophy Type 2B (LGMD 2B) and Miyoshi Myopathy (MMD1) and affect ~1:100,000 individuals worldwide. Dysferlin is...
Paramyxoviridae and Bunyavirales Vaccines and Antibodies Center (PABVAX)
PROJECT SUMMARY/ABSTRACT - Overall Emerging and reemerging pathogenic RNA viruses represent continuous infectious disease and pandemic threats to public health. Among the many grou...
Core A: Administrative Core
PROJECT SUMMARY/ABSTRACT - Core A (Administrative Core), The University of Texas Medical Branch at Galveston The Administrative Core is responsible for the overall management and c...
Core B: Data Management
PROJECT SUMMARY/ABSTRACT – Core B (Data Management Core) Data and derived knowledge are valuable by-products of scientific investigations and are crucial in verifying and reproduci...
Core C: Microneedle Patch Vaccines
ABSTRACT/PROJECT SUMMARY - Core C (Microneedle Patch Vaccines) The threat of emerging and re-emerging infectious diseases highlights the need for continued improvement of vaccinati...
Core D: Early and IND-Enabling Translational Research for Vaccines and MAbs
ABSTRACT/PROJECT SUMMARY – Core D (Early and IND-Enabling Translational Research for Vaccines and mAbs) Core D will leverage the relationship between vaccines and antibodies to opt...
Core E: Animal Model Development and Preclinical Evaluation
PROJECT SUMMARY/ABSTRACT – Core E (Animal Model Development and Preclinical Evaluation) Among viruses that cause disease in humans, viral zoonoses within the family Paramyxoviridae...
RP1: Antigen design and testing of arenavirus and nairovirus
PROJECT SUMMARY/ABSTRACT – RP1 (Antigen Design and Testing Of Arenavirus And Nairovirus Vaccines) The viral order Bunyavirales contains several high priority human pathogens. Notab...
RP2: Vaccines and antibodies to henipavirus
PROJECT SUMMARY/ABSTRACT - RP2 (Vaccine and Antibodies Against Henipaviruses) Pathogenic RNA viruses represent continuous infectious disease and pandemic threats to public health....
RP3: Cedar henipavirus animal model
PROJECT SUMMARY/ABSTRACT – RP3 (Cedar Henipavirus Animal Model) Henipaviruses are single-stranded, negative-sense enveloped RNA viruses of the paramyxovirus family. Two henipavirus...
RP4: Monoclonal antibodies against henipaviruses, arenaviruses, and nairoviruses
PROJECT SUMMARY/ABSTRACT – RP4 (Monoclonal Antibodies against Henipaviruses, Arenaviruses and Nairoviruses) The paramyxoviruses, nairoviruses, and arenaviruses represent collection...
RP5: Nanobody therapeutics against henipaviruses, arenaviruses, and structural characterization
Abstract The COVID-19 pandemic has emphasized the pressing need for rapid drug development and novel antiviral therapies. Nanobodies, derived from camelid animals, show promise as...
Leveraging SNAP Policies to Improve the Cardiovascular Health of Low-Income Adults in the United States
PROJECT SUMMARY/ABSTRACT More than 34 million people experience food insecurity in the US, and 1 in 3 households with low incomes are food insecure. A growing body of evidence sugg...
Neuromuscular response to competing ACL surgeries
ABSTRACT The overall project objective is to leverage patients enrolled in the BEAR-MOON Trial to evaluate a neuromuscular mechanism that may explain differences in functional outc...
Epigenomic consequences of breakage-fusion-bridge cycling
Project Summary Chromosome breakage can generate extraordinary genetic novelty that is selected upon during tumor progression. One commonly observed feature of cancer is the breaka...