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99,167 grants found
Showing 4,261 – 4,280 of 99,167 grants
Kinase Regulation of Nuclear Speckle Function and Splicing during Influenza Virus Infection
PROJECT SUMMARY (PARENT GRANT) The goals of this proposal are to uncover how pre-mRNA splicing and nuclear speckles are controlled by the kinase TAO2, and to determine why TAO2 is...
INcreasing CLinical Trial OpportUnities anD Enrollment of Non-English Speaking Research Subjects: A Revised Research Pathway (INCLUDE)
The dramatic underrepresentation of Non-English speakers (NES) in clinical trials contributes to health inequities and compromises the generalizability of research. Barriers to enr...
SCH: Topological Methods for Breast Tissue Quantification
To better understand breast cancer and its response to treatment, the key is to understand breast tissue architecture. Modifications to tissue architecture are a direct consequence...
SCH: Fair and Interpretable Prediction of Alzheimer's Disease and MCI using LLMs
This proposal aims to develop high-performing, fair, and interpretable large language models (LLMs) to detect Alzheimer's disease (AD) and its precursor stages. In doing so, i...
SCH: Training Mental Health Supporters with Virtual Patients and Automated Feedback
Under-treatment of mental health problems remains a major issue in the US, especially for youth, people of color, and individuals with low incomes. Technology may help reduce dispa...
SCH: Human-Robot Contact for Bathing and Skin-Care Assistance
For individuals with a broad range of disability, illness, or injury, skin health can be challenging to maintain. One devastating result is the high national incidence and impact o...
SCH: Synchronous Dyadic Physiological Monitoring for Real Time In Vivo Measurement and
Animal-Assisted Interventions (AAIs) are goal-oriented programs that intentionally incorporate animals, such as dogs, for therapeutic benefits. AAIs are widely used in a variety of...
SCH: Robust Multimodal Longitudinal AI for Enhanced Breast Cancer Screening
The overarching objective of this project is to optimize and personalize breast cancer screening by advancing artificial intelligence (AI) algorithms. Breast cancer is a major glob...
FKBP5 AND CARDIAC ARRHYTHMOGENESIS
PROJECT SUMMARY Atrial fibrillation (AF) is the most frequent arrhythmia. AF is uniquely associated with the development of heart failure with preserved ejection fraction (HFpEF)....
SCH: Personalized AI-Driven Models for Supporting User Engagement and Adherence in Health Interventions: Validation in Cognitive Behavioral Therapy for Anxiety
Untreated anxiety undermines long-term physical and emotional wellbeing, especially among college students, with rates worsening since the onset of the COVID-19 pandemic. Cognitive...
High sensitivity NMR for structure determination of neurodegenerative disease associated protein aggregates in native contexts
Per SPA document not needed
Functional analysis of histone modifier Autism Spectrum Disorders risk genes in vertebrate development
PROJECT SUMMARY (See instructions): Autism comprises a class of developmental disorders characterized by significant social, communication, and behavioral challenges. Autism is tho...
CRCNS": Brain-derived network architectures for deciphering and applying brain algorithms
Our LONG-TERM GOAL is to extend current biological and artificial vision research from a focus on 2D image recognition toward visual understanding of 3D structure in the real world...
CRCNS: Neural circuits for egocentric and allocentric cognitive maps in humans
PROJECT SUMMARY (See instructions): Cognitive maps allow humans to mentally represent their spatial environments and are thus essential for navigation and memory in everyday life....
Molecular mechanisms of transcriptional regulation of phototransduction genes in mammalian rod photoreceptors
Transcriptional elongation and mRNA processing occur simultaneously and are highly coupled to increase the efficiency and accuracy of mRNA maturation. Splicing is a step of mRNA pr...
Brain glucose deficiency: mechanisms and modulation
BRAIN GLUCOSE DEFICIENCY: MECHANISMS AND MODULATION. ABSTRACT Biochemical principles and experimental and clinical observations support the centrality of glucose metabolism to brai...
Gravida traumatic brain injury (TBI) impacts neurodevelopment of the offspring
PROJECT SUMMARY Intimate partner violence (IPV) increases the risk of traumatic brain injury (TBI), because the physical assaults target the head, neck, and face. Women, more than...
Targeting the Choroid Plexus-Cerebrospinal Fluid System to Treat Post-Hemorrhagic Hydrocephalus
PROJECT SUMMARY (Parent Grant) Post-hemorrhagic hydrocephalus (PHH) is a leading cause of morbidity in premature infants. PHH is triggered by germinal matrix intraventricular hemor...
Rhes-SUMO Pathway in Huntington disease
Project summary of the funded parent award Huntington disease (HD) is a slowly progressing genetic disorder caused by an expansion of glutamine repeats in the huntingtin protein (w...
Genetic, Tissue, and Anatomical Interactions in Mandibulofacial Dysmorphogenesis
PROJECT SUMMARY Anomalies of the face invariably require some type of therapy, corrective surgery, and close follow-up while imposing a financial and emotional burden on patients a...