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99,167 grants found
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Dissecting and targeting PAK4 in Ewing sarcoma
Ewing sarcoma (ES) is the second most common bone tumor in the pediatric population and is defined by a pathognomonic translocation, most frequently EWS::FLI1, which leads to the e...
Ultra-high resolution imaging of category-selective visual cortex in autism
Project Summary Autism is a pervasive developmental disorder that is characterized by impaired social cognition. Social cognition depends critically on basic perceptual processes,...
The role of chromatin regulators in neurodevelopmental disorders
Abstract We propose to investigate the role of the chromatin methyltransferase DOT1L in neuronal function and determine how its disruption leads to neurodevelopmental disorders (ND...
Dysfunctional organelle-specific autophagy leads to brain ischemia-reperfusion injury
PROJECT SUMMARY: Transient cerebral ischemia occurs in various clinical scenarios, including transient ischemic attack (TIA), cardiac arrest, hypovolemic shock, cardiac surgery, an...
Elucidating minority stress influences on tobacco use at the intersection of sexual orientation and rurality
SUMMARY/ABSTRACT The US tobacco market has evolved over the past decade with declines in cigarette use coupled with increases in the use of other tobacco products (e.g., e-cigarett...
Development and Plasticity of Neural Circuits Underlying Sound Encoding
Project Summary Functional diversity of Type I spiral ganglion neurons (SGNs) in the cochlea is a fundamental feature of mammalian auditory circuits thought to support the wide dyn...
Targeting DHX9 to trigger viral mimicry and immunotherapy responsiveness in Small Cell Lung Cancer (SCLC)
PROJECT SUMMARY / ABSTRACT Despite the impressive clinical success of Immune checkpoint blockade (ICB) therapy in cancer, therapy resistance is common and only a small subset of pa...
Creating transgenic mouse models that genetically and phenotypically recapitulate pachyonychia congenita
SUMMARY Orphan diseases are individually rare but collectively affect a significant fraction of the population. Such conditions are often misdiagnosed and lacking in effective ther...
The Role of GPNMB in Parkinson's Disease.
Epidemiology and population genetics suggest that Parkinson’s disease (PD), Lewy Body Dementia (LBD) and related synucleinopathies, results from a complex interaction between genet...
A new humanized mouse model to study HBV gene editing
Project Summary Chronic Hepatitis B virus (HBV) infection (CHB) affects hundreds of millions of people across the world. Despite effective vaccines, and antiviral therapies that ca...
Complement in the Pathogenesis of Acute Chest Syndrome
Project Summary Sickle Cell Disease (SCD) is characterized by vasoocclusion of blood vessels and chronic hemolytic anemia, resulting in recurrent and episodic acute organ damage. A...
Intratumoral microbiota and immune predictors of response to immunotherapy in lung cancer
ABSTRACT Although immunotherapy, especially immune checkpoint inhibitors (ICIs), has emerged as a powerful cancer treatment, less than half of advanced Non-Small Cell Lung Cancer (...
Mechanisms of mRNA-selective control by Bicaudal-C
Abstract: Over the course of an animal’s lifetime, cell-fate decisions are continually being made that allow for normal development and growth as well as the health of the adult or...
LONGITUDINAL ASSOCIATION OF POST-INFARCT LIPOMATOUS METAPLASIA AND MALIGNANT ARRHYTHMIA
Myocardial infarction (MI) from coronary artery obstruction affects more than 1 million people annually in the United States resulting in symptoms, reduced quality of life, and sub...
Examination of factors influencing the racial disparity in fibroid incidence
PROJECT SUMMARY Uterine fibroids are the most common pelvic tumors in women of reproductive age, coming to clinical attention in one in four women. Fibroids are 2-3 times as common...
Multi-electroplasmonic nanoantenna arrays for wireless transmembrane-level recording of cardiomyocyte action potentials with sub-micrometer resolution
Cardiovascular disease is the leading cause of morbidity and mortality worldwide and is responsible for 20% of deaths inthe United States alone. Among both disabling and fatal even...
Clinical decision-support algorithms for interactive design of patient-specific breast molds
Breast reconstruction can help feminine-presenting individuals retain or regain quality of life by mitigating the impacts of body image disruption due to appearance changes arising...
STRESS, MEMORY, AND RUMINATION IN MALTREATED ADOLESCENTS
Project Summary Child maltreatment is one of the most formidable public health crises in the United States, affecting millions of youth each year. The adverse consequences of maltr...
Innovative mRNA vaccines to enhance the efficacy of T-cell transfer therapies against solid tumors
ABSTRACT The remarkable effectiveness of the COVID-19 mRNA vaccines heralds a transformative immunization platform against viral infections. A key innovation—recognized with the 20...
Long-term Effects of Educational Investments on Cognitive Health
Project Summary One of the most robust findings in dementia research is that high educational attainment lowers the risk of Alzheimer's disease and related dementia (ADRD); a...