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Active NON-SBIR/STTR RPGS NIH (US)

STRESS, MEMORY, AND RUMINATION IN MALTREATED ADOLESCENTS

$6.38M USD

Funder EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
Recipient Organization University of California-Irvine
Country United States
Start Date Aug 01, 2024
End Date Apr 30, 2029
Duration 1,733 days
Number of Grantees 1
Roles Principal Investigator
Data Source NIH (US)
Grant ID 10982189
Grant Description

Project Summary Child maltreatment is one of the most formidable public health crises in the United States, affecting millions of youth each year. The adverse consequences of maltreatment for youth, as well as for their families and entire communities, are pervasive, costly, and enduring. To intervene and reduce these consequences, it is imperative that victims provide clear and

accurate accounts of their prior experiences. Currently, considerable skepticism exists regarding maltreated youth’s ability to provide such accounts, especially for experiences that were stressful, leading to youths’ reports being challenged or not believed. We contend that this skepticism is unwarranted, and maltreated youth actually demonstrate better memory than their

non-maltreated counterparts, but only for stressful salient personal experiences. We will ethically and rigorously test this possibility in the proposed study via a short-term longitudinal experimental investigation that compares the effects of acute stress on memory between maltreated and demographically matched non-maltreated 12-17-year-olds. In an initial in-person

session, youth will be randomly assigned (equal maltreated and non-maltreated youth across age) to complete standardized salient personal activities that are experimentally manipulated to vary in whether they induce higher or lower levels of acute stress. Immediately afterward, youth will complete an encoding task comprised of positive, negative, and neutral images. In

subsequent sessions (two remote and one in person) spanning approximately one month, youth’s memory will be tested for the images via a recognition task asking them to discriminate previously seen from unseen images and for the personal activities via recall and direct questions that probe for the extent and accuracy of memory. Youth’s rumination about the

personal activities will also be measured. Our main hypothesis is that maltreatment will lead to particularly robust memory for the personal activities, but only when the youth complete these under conditions of high stress. By contrast, because the emotional and neutral images are not personally meaningful, we expect maltreatment to constrain youth’s memory performance for

the images. We also hypothesize that rumination will serve as an important mediator of the links between stress and memory for the higher stress personal activities, most notably in the maltreated youth. Overall, our results will provide much-needed knowledge about the precise ways that maltreatment shapes different facets of youth’s memory, knowledge that will be

enormously valuable in improving trust in maltreated youth’s reporting of stressful experiences and hence in directing interventions for victimized youth.

All Grantees

University of California-Irvine

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