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99,167 grants found
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Prioritization and Bioactivity Characterization of Novel Bile Acids Produced by the Microbiome
Project Summary – Through 170-years of bile acid (BA) chemistry research, our knowledge of mammalian BA conjugation was limited to the amino acids glycine and taurine. Our group re...
Multi-Omic Characterization of Immune Cells in Sarcoidosis
ABSTRACT Sarcoidosis is a systemic granulomatous disease with striking heterogeneity of clinical course and increasing mortality and morbidity rates. Diagnosis is difficult and pre...
BACH1 as a novel pioneer repressor in macrophages: impact on homeostasis and inflammation
PROJECT SUMMARY Transcription plays an oversized role in determining proper inflammatory response in immune cells such as macrophages (MF). Transcriptional master regulators of MFs...
Role of specialized pro-resolving mediators of inflammation resolution in emphysema: analyses of SPIROMICS and LEEP
Project Summary/Abstract Inflammation is a central pathologic mechanism across a variety of chronic diseases, including cardiovascular, metabolic, and pulmonary disorders. Current...
Addressing Food Insecurity in the Health Care Setting to Promote Health Equity
PROJECT SUMMARY/ABSTRACT Social Determinants of Health (SDoH), or the environment and conditions in which one lives, can greatly impact one’s health and quality of life. In the Whi...
Novel Glucose dendrimers for targeting injured neurons
Project Summary Preserving and repairing injured neurons is the primary goal of treatments for brain injuries. Yet, delivering therapeutics specifically to neurons has been a chall...
Community Health Workers in an Interdisciplinary Outpatient CKD Clinic to Optimize Social Care Navigation, Patient Engagement, and Home Dialysis Utilization- the CHOOSE Home trial
PROJECT ABSTRACT Despite overrepresentation in the end-stage kidney disease (ESKD) population, African American/Black and Latinx/Hispanic patients are less likely to have optimal t...
Molecular timekeeping and temporal cell fate specification in C. elegans
ABSTRACT/SUMMARY Development is an inherently dynamic process that operates on diverse timescales. Coordinating gene expression, cell fate determination, and tissue growth is cruci...
Investigating the Function of Highly Similar Intrachromosomal Repeats to Genomic Instability and Perturbed Gene Expression in Genetic Disorder
1. Project Summary De novo and ultra-rare copy-number variants (CNVs) often underlie the genetic etiology of pediatric and neurodevelopmental diseases. As such, CNVs provide opport...
Engineering Enzymes for Improved Stability and Retained Function via Rapid Design-Build-Test-Learn Cycles integrating AI/Physics based predictions with Cell-free Protein Synthesis Experimental Testing
Abstract The transformative breakthrough of Google DeepMind’s AlphaFold2 on the reliability of sequence to protein structure prediction, demonstrated the power of machine learning...
Prospective associations between neighborhood environments and physical activity and weight status across age groups: secondary analyses combining 5 NIH studies
PROJECT SUMMARY/ABSTRACT Physical inactivity is a leading risk factor for obesity and cardiovascular disease across age groups. Numerous studies across the lifespan have found cros...
Cell Death Programs as Fundamental Drivers of Inflammation and Multi-Organ Injury
Project Summary/Abstract Inflammation is an essential component of vertebrate immunity against invading pathogens, foreign insults, or abnormal physiologic conditions. Cellular dea...
Mechanisms of intracellular transport and processing of neuropeptides
Project Summary/Abstract A major form of communication between cells, including the nervous system, is the release of small, chemical factors, like neuropeptides (NPs) and hormones...
Social Interactions and Cognitive Health in Older Immigrants: Bonding/Bridging/Bullying in Senior Housing
PROJECT SUMMARY In response to the NIH’s (RFA-AG-24-029) interest in understanding the role of immigration on life course health and aging, the proposed study aims to examine how o...
Alternative splicing in the mouse inner ear at single cell resolution
Sensorineural hearing loss and vestibular dysfunction are common sensory disorders affecting millions of individuals worldwide¹,². The primary cause of both hearing loss and periph...
Molecular Consequences of Myotonic Dystrophy Type 2-causing CCTG DNA Repeats
Project Summary Myotonic dystrophy type 2 is a genetic disorder characterized by progressive muscle wasting and weakness that is caused by long CCTG DNA repeats. Individuals can ha...
Improving Interpretation of Hearing- Related Patient Reported Outcomes for Bilingual Adults
PROJECT SUMMARY/ABSTRACT In the Audiology clinic, decision making is guided by evidence-based research supporting best practices, with integration of multiple data sources includin...
Rewired Signaling at the Nexus of Melanoma Metastasis and Resistance
Summary This R35 focuses on novel mechanisms underlying control of key UPR components that impact melanoma metastasis in aged rather than young mice by (i) tumor-intrinsic mechanis...
Salivary peptide/protein-based multilayer denture coatings for controlling Candida biofilm formation and denture stomatitis
Project Summary/Abstract: Candida-associated denture stomatitis (CADS), due to Candida colonization and biofilm formation on the denture surface, is a significant clinical concern...
Health Equity in Alzheimer’s Treatment (HEAT)
Project Summary/abstract Alzheimer’s Disease and Alzheimer’s Disease-Related Dementias (AD/ADRD) are common and increasing across the world. Black and low-income populations have a...