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Neuroinflammation, Perineural Nets, and Postoperative Delirium
The aging brain is associated with an increased risk of developing postoperative delirium (POD), postoperative neurocognitive disorder (PNCD), and Alzheimer’s disease. POD occurs i...
Digital Strategies to Advance Help-Seeking in Youth at Clinical High Risk for Developing Psychosis
Project Summary Early psychosis intervention is critical to improving clinical and functional outcomes, yet treatment initiation is typically delayed for months to years, resulting...
Absolute Brain Thermography using Multinuclear MRI
PROJECT SUMMARY Stroke is the leading cause of disability, the second leading cause of dementia, and the second leading cause of death worldwide, affecting nearly 800,000 patients...
The role of Rok and its substrate Cmb the male germline
The role of Rok and its substrate Cmb the male germline Traditionally, Rho kinase (ROCK, Rok in flies) functions as effector of the non-canonical Wnt/Frizzled PCP pathway during ga...
Neural computations of learning, decision-making and memory
Most of our behavior consists of learning about the environment, choosing between options that we learned about, and storing the learning in memory for future use. These processes...
Genetic investigations of cardiometabolic disease: pleiotropy, gene x environment and causal inference analyses
PROJECT SUMMARY Cardiometabolic disease refers to a set of clinically overlapping diseases, including coronary artery disease, stroke, type 2 diabetes, hypertension, kidney disease...
A Randomized Trial of a Remotely Delivered Group Pelvic Yoga Program for Women with Chronic Pelvic Pain Syndrome
PROJECT SUMMARY One out of seven women suffer from chronic pelvic pain, a syndrome leading to depression, social isolation, sexual dysfunction, physical inactivity, and progressive...
Multi-omic Characterization of COPD in Females
ABSTRACT COPD is the fourth leading cause of death for women in the United States, which has a strong genetic basis. Studies have demonstrated the heritability of COPD to be ~40%....
Modulation of host chromatin dynamics and gene expression by viral biomolecular condensates
Project Summary This project will use model RNA plant viruses to elucidate the mechanisms used by viruses to target nucleoli and regulate chromatin dynamics and host gene expressio...
Multi-omics study of ancestry enriched associations in Hispanics/Latinos
ABSTRACT This proposal builds into our ongoing research in genetics and disease risk in admixed Hispanic populations. Hispanics/Latinos are the larger racial/ethnic minority in the...
Creation of the Human Cancer Metabolome Atlas
Project Summary/Abstract Metabolic reprogramming is a hallmark of cancer, prompting molecular mechanisms to promote tumor survival, growth, and resistance to treatment. Therapeutic...
Breastfeeding Education Support Tool for Baby
PROJECT SUMMARY Optimal infant feeding practices, including exclusive breastfeeding (EBF) for 6 months, play a critical role in determining the health, growth, and development of c...
Critical protein interactions for piRNA biogenesis
PROJECT SUMMARY P-element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are ~24-34 nt non-coding RNAs that have been discovered in diverse species. Repressing the expressio...
Identify actionable drugs that enhance resilience in Alzheimer's disease individuals
Alzheimer's disease (AD) is a progressive neurological disorder that affects millions of people worldwide. Whilesignificant efforts have been made to develop treatments target...
Epithelial stem cell dysfunction in diabetic oral ulcer
PROJECT ABSTRACT Diabetes mellitus significantly delays the healing of epidemic wounds as well as oral wounds, posing a difficult clinical challenge for oral surgeries such as toot...
Establishing Basic Science-Clinical Collaborations to Understand the Molecular Mechanisms of Heterotaxy
Congenital heart disease (CHD) is the most common birth defect that affects nearly 1 in 100 liveborn infants. Heterotaxy (HTX) is a severe form affecting 3-4% of CHD patients where...
A Biological Theory of Attention Control in the Framework of Rational Meta-Reasoning
Summary Attending to informative stimuli is critical for choosing appropriate actions, but the biological mechanisms underlying this ability are not well understood. Recent theoret...
DEVELOPING GPCR MODULATORS OF SOMATOSTATIN INTERNEURONS FOR THE TREATMENT OF OPIOID USE DISORDER
Approved medications and available treatments for opioid use disorder (OUD) do not adequately address long- term changes in cravings, motivation, and mood; thus, while tragic, it i...
Optoeletronic Micro-Gadget (OMG): a Photoelectrochemistry-Enabled Multi-Utility Lab-on-a-Chip System for Precise and Localized Sensing and Actuation
PROJECT SUMMARY/ABSTRACT Problem statement: The investigation and manipulation of complex biological systems require lab-on-a-chip (LOC) systems that can perform spatially resolved...
From Research to Clinic: Addressing Ethical and Policy Challenges Facing the Gene Therapy Ecosystem
PROJECT SUMMARY The U.S. Food and Drug Administration has approved gene therapies for several rare inherited diseases and blood cancers, and hundreds of clinical trials are in prog...