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99,167 grants found
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PNA-STAMPs: Versatile, Potent and Targeted Antibiotics
Project Summary There is a critical need to develop therapies targeting Streptococcus pneumoniae (Spn): a major human pathogen contributing to global morbidity and mortality. We pr...
Modeling the effect of outdoor air pollution on the health and function of the retina
Pollution levels in the USA are rising due to climate change, wildfires and increased vehicle traffic. Recent epidemiological studies indicate that air pollution is a contributing...
Post-transcriptional gene regulation by the exon junction complex
PROJECT SUMMARY OF THE PARENT PROJECT The supplement will facilitate the parent grant summarized here by supporting an equipment purchase to fulfill the original scope of work. Non...
Determinants of response to cancer immunotherapy
PROJECT SUMMARY/ABSTRACT While immunotherapy is transforming cancer treatment, the majority of patients do not achieve durable responses. We have been studying response and resista...
Parasite-Derived Vesicles in Babesia virulence and Vaccine Development
Research Summary: The May 2018 edition of CDC Morbidity and Mortality Weekly Report (MMWR) highlighted the alarming increase in the number of reported vector-borne disease cases in...
Inhibition of virus replication by broadly-acting recombinant enhanced antiviral restrictors (REAVRs)
Project Summary: Zoonotic viral infections are responsible for the majority of emerging and re-emerging infectious diseases in humans. The current strategies for controlling vector...
First murine animal model and adeno-associated virus (AAV)-based gene therapy for MTATP6 mitochondrial diseases
Project Summary/Abstract This proposal aims to provide crucial training for the applicant’s long-term career plan to develop gene therapy approaches for patients with neurological...
2024 ICEMR Annual Workshop and Scientific Advisory Group Meeting
Project summary The National Institute of Allergy and Infectious Diseases, National Institute of Health, has established 11 international centers of excellence in malaria research...
Neurophysiological biomarkers in preclinical assays of risk propensity
PROJECT SUMMARY: Individual humans and animals can lie anywhere along a continuum of high to low risk- taking propensity. Several neuropsychiatric conditions are characterized by e...
Biogeography of the peri-implant microbial ecosystem in health and during transition to disease
ABSTRACT Dental implants restore chewing function to at least 100 million individuals and the market continues to grow 15% annually. However, over one million implants fail every y...
Contribution of Truncated TrkB Isoform in Oral Cancer Pain
Project Summary This research will address the critical issue of pain in patients with head and neck carcinoma (HNC), which significantly impairs their quality of life. Many HNC pa...
IMPACT OF BCL2 PHOSPHORYLATION ON HIV DYNAMICS, RESERVOIR SIZE AND SUSCEPTIBILITY TO VENETOCLAX
PROJECT SUMMARY Following HIV infection, a subset of T cells do not die and can revert to a latent state of infection. Much research over the past decade has consistently found tha...
Gaining a clear view of HIV cell-cell spread using APEX proximity labeling
Project Abstract This project aims to better understand the molecular mechanisms of HIV spread through cell-cell contact across a virological synapse (VS), a specialized structure...
STudy of Acute HIV for investiGating Eradication Strategies (STAGES)
PROJECT SUMMARY/ ABSTRACT The goal of HIV cure research is to induce “antiretroviral therapy (ART)-free” remission by eliminating persistent HIV to overcome the need for lifelong A...
Enhancing HIV-1 vaccines by altering vaccine dose
PROJECT SUMMARY: Developing a vaccine against HIV is thus a research priority, but it has been difficult in part because vaccines have not been able to generate sufficient antivira...
Neurocircuitry of motivated reward-seeking after stress
Project Summary/Abstract Stress is a risk factor for the development of neuropsychiatric disorders. Over recent years, it is becoming increasingly clear that dopaminergic circuitry...
Advancing On-Slide and Optical Biopsy Tools to Detect High-Risk Oral Premalignancy
PROJECT SUMMARY Despite the dismal five-year overall survival rate, a moderate response rate to treatments, and one of the highest suicide rates among cancer patients, human papill...
Understanding the Mechanism of HIV Associated with Diabetic Complications in Low- and Middle-Income Country
PROJECT SUMMARY Our proposed project is designed to investigate the immunopathological basis of NK cell-mediated pancreatic insufficiency which may lead to the future occurrence of...
Mechanistic Investigation of Neuropathological Interactions between COVID-19 and Progression of Lewy Pathology and Dementia
Project Summary/Abstract Neuropathological interactions between COVID-19 and ADRD suggest shared molecular and cellular mechanisms. A recent case series study revealed striking cut...
Pro-apoptotic Drugs as Host-Directed Treatments for Pulmonary Tuberculosis
During the early phase of infection, Mycobacterium tuberculosis proliferates in macrophages and other cells, preventing apoptosis by the induction of proteins such as from the Bcl-...