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99,167 grants found
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Mouse Model and Pathological Analysis Core
CORE 2 - MOUSE MODELS AND PATHOLOGICAL ANALYSIS CORE: SUMMARY The purpose of Core 2 is to support the research of each of the projects in the ELEVATE program project grant (PPG) by...
Biostatistics and Bioinformatics Core (BBC)
CORE 3 - BIOSTATISTICS AND BIOINFORMATICS CORE: SUMMARY The overarching goal of the ELEVATE program project grant (PPG) is to leverage molecular abnormalities in hepatocellular car...
Functional Consequences of Early Childhood Otitis Media
PROJECT SUMMARY/ ABSTRACT Auditory deprivation during childhood has serious consequences on all aspects of development. Otitis media (OM) is a highly prevalent condition in young c...
Antibody bound bacteria during HPV infection and cervical dysplasia
PROJECT SUMMARY High-risk human papillomavirus (HR-HPV) is a known cause of >95% of cervical cancer and cervical intraepithelial neoplasia (CIN). Prophylactic vaccines are avail...
Precision Tumor Sampling of Melanoma Using Laser Microbiopsy
ABSTRACT Melanoma is the fifth most common cancer in the US with almost 100,000 cases estimated for 2023. Late-stage disease has a five-year survival of just 30%, resulting in almo...
Paradigm Shift in the Management of Patients with Previously Untreated Chronic Lymphocytic Leukemia through NCI-sponsored Clinical Trials
PROJECT SUMMARY Dr. Parikh is a consultant in the Division of Hematology, Department of Medicine at Mayo Clinic in Rochester, MN, and holds the rank of Associate Professor of Medic...
Targeting the tumor microenvironment with engineered CD4+ T cells
Abstract Novel immune therapies are needed to help the majority of patients with melanoma and other solid tumors who fail to benefit or stop responding to immune checkpoint inhibit...
RSMI HEALS
Project Summary/Abstract There are 26 million limited English proficient (LEP) people in the U.S. population (those who speak English less than “very well”); the two most frequentl...
Understanding the pathogenesis of classic Hodgkin lymphoma in persons living with HIV through conventional and spatial transcriptomics
PROJECT SUMMARY/ABSTRACT The incidence of hematological malignancies is higher in persons living with PLWH (Persons living with HIV (Human Immunodeficiency Virus)). The risk of dev...
Regenerative and Rehabilitation Strategies to Reduce Inflammation Following Volumetric Muscle Loss Injury
PROJECT SUMMARY Current soft tissue repair techniques have not been able to reverse the pathological changes that occur following volumetric muscle loss (VML) injury. The key event...
DeepTOBIDx: deep learning-enhanced multimodal diagnostic breast imaging
PROJECT SUMMARY / ABSTRACT Imaging modalities routinely used in the diagnostic workup, i.e., mammography, ultrasound, and MRI, can catch breast cancers at an early stage based on s...
Circuit, cellular, and molecular plasticity in hypothalamic microcircuits underlying flexible infant-directed behavior
ABSTRACT Human parents and non-parents show sharply distinct patterns of brain activity in response to infant cries or laughter. How is this change in brain responses accomplished?...
Post-transcriptional control of gene expression by the mTORC1 signaling pathway
Project summary The translation of mRNAs into protein is a fundamental step in gene expression that is regulated by diverse cellular signals. How these regulatory mechanisms are us...
Multi-scale, multi-modal imaging assessment of trajectories of cognitive impairment in Multiple Sclerosis
Cognitive impairment is highly prevalent in patients with multiple sclerosis (MS) and increases in severity with disease progression. Unfortunately, treatment options for MS-relate...
Novel Designed Multi-Ligands as Tocolytics for Dysregulated Myometrial Pathways in the Treatment of Preterm Labor
PROJECT SUMMARY ABSTRACTPreterm birth is a major medical problem resulting in disability and death for very preterm infants. Therapeutic approachesto manage preterm labor are off-l...
TMJ Disc Regeneration
Patients opting for TMJ disc removal face issues due to the absence of FDA-approved replacements, leading to bone-to-bone contact and subsequent joint problems. Autografts, like de...
Revealing New Therapeutic Opportunities for Kidney Glomerular Diseases by Elucidating the Mechanobiological Functions of Novel Cytoskeletal Structures in Podocytes
Project Summary Chronic kidney diseases, of which glomerular diseases form the most significant component, are quite common and estimated to affect from 5 to 11% of the population....
Non-ISGylated HIV proteins are sorted to hepatic exosomes to activate liver fibrosi
In an era of improved survival due to modern antiretroviral therapy (ART), liver disease has become a major cause of morbidity and mortality among HIV-infected persons causing deat...
Elucidating circuit mechanisms of brain rhythms in the aging brain
PROJECT SUMMARY Brain rhythms coordinate the activities of thousands of neurons across multiple brain areas for complex cognitive functions. The hippocampal theta (4-12 Hz) rhythm,...
Translational development of new agents alone and in combination to combat Gram-negative pathogens important in Ventilator- Associated Bacterial Pneumonia: Leveraging the Gram-negative toolbox that is
Project Summary/Abstract: Resistance to our major antibiotics has been identified by the CDC as a major threat to the health and safety of the American public. Two of the highest t...