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99,167 grants found
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Neuroanatomical and molecular architecture of high- and low-level circuits controlling orofacial movements
Project 4 Summary Motor circuits in the vertebrate brain are arranged hierarchically. Low-level circuits in the brainstem and spinal cord – such as the oscillators and pattern gene...
Top-down and bottom-up signals for flexible orofacial behaviors
Abstract Project 5: Top-down and bottom-up signals for flexible orofacial behaviors (O’Connor as lead) Orofacial behaviors involve sequences of individual motor actions — such as c...
Administrative Core
Project Summary/Abstract – Administrative Core The Administrative Core is the organizational underpinning for the proposed studies. These are organized into five projects across fo...
Data Science Core
Core 1. Abstract Data Science Core The Data Science Core aims to streamline TeamBCP's data management and sharing by overhauling its server infrastructure and data conversion...
Quantitative Neuroanatomy
Abstract Core 2: Quantitative Neuroanatomy The neuroanatomy of orofacial circuitry has grown in complexity as viral-genetic tracing methods uncover neuronal projections of a myriad...
Advanced Nonlinear Imaging
Core 3. Abstract Nonlinear Imaging Two-photon laser scanning microscopy (TPLSM) has enabled in vivo studies on the function of neuronal circuitry. However, the penetrating depth of...
Novel Targets in aging-associated sepsis and organ failure
Summary/Abstract This “test of concept” R21 is to explore a novel concept on the role of circular RNAs in aging-related sepsis and organ damage. Circular RNA (circRNA) is a type of...
Developing Gyrencephalic Models of TBI-Induced ADRD Neuropathology
PROJECT SUMMARY / ABSTRACT There has been considerable concern regarding the long-term effects of traumatic brain injury (TBI), largely driven by reports of neurodegenerative prote...
From functional to dysfunctional neural network dynamics underpinning memory storage and retrieval across young adult and aged mice
The goal of this project is to investigate changes in the temporal dynamics of cholinergic modulation during aging and the extent to which these changes contribute to alterations o...
Weight Stigma among Doctoral Clinical Psychology Students: Examining Change and Testing Underlying Mechanisms.
Project Summary/Abstract Weight stigma is a modifiable risk factor that negatively impacts the health and well-being of higher-weight people and those with lower BMI who simply per...
An Application of SMART Methodology to Optimize an Intervention to Maintain Improvements in Health Behaviors in Under-resourced Patients after Phase II Cardiac Rehabilitation
PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is the leading cause of death in the United States. Cardiac rehabilitation (CR) is an evidence-based, cost-effective, and wide...
Role of Ca2+ Signaling by 3D Osteocyte Networks in Mechanoadaptive Response of the Bone Multicellular Unit
Summary Osteocytes are the most numerous cell in bone tissue, which act as mechanosensors and coordinate adaptive bone remodeling. Current model systems have been unable to unify t...
Using artificial intelligence to bridge human and murine studies of lupus nephritis progression
PROJECT SUMMARY Lupus nephritis (LN) is the most common severe manifestation of systemic lupus erythematosus (SLE) Disease progression is associated with tubulointerstitial hypoxia...
Synergistic Enhancement of ER proteostasis, trafficking, and lysosomes as treatments for Dementia with Lewy bodies and Parkinson’s disease-dementia
AbstractDementia with Lewy bodies (DLB), Parkinson’s disease (PD), and PD-Dementia (PDD) are all classified as synucleinopathies due to the accumulation and aggregation of a-synucl...
A Novel Therapeutic Strategy Targeting Neuroinflammation for Global Cerebral Ischemia Associated with Cardiac Arrest
PROJECT SUMMARY/ABSTRACT Each year, over 200,000 Americans suffer from global cerebral ischemia associated with cardiac arrest leading to cognitive deficits or death. While emergen...
Individual Patient Data Meta-Analysis of Red Blood Cell Transfusion Trials Comparing Liberal versus Restrictive Thresholds
Project Summary Accumulating evidence from individual clinical trials and conventional trial level meta-analysis suggests that restrictive transfusion threshold of 7 to 8 g/dL is a...
A cross-species approach to hypersomnia genetics informed by human GWAS
Idiopathic hypersomnia (IH) is a poorly understood disorder characterized by excessive daytime sleepiness despite normal nighttime sleep, often accompanied by difficulty awakening,...
Role of carnosine in peripheral arterial disease
Abstract Peripheral arterial disease is a serious manifestation of atherosclerosis in the lower extremities. Current interventions approved by FDA are either ineffective or have a...
Cell Competition in Development and Homeostasis
A process of cell competition can remove cells that differ genetically from neighboring cells in the same tissues. Cell competition helps to eliminate sporadic aneuploid cells that...
RESTOR [Rapamycin and Everolimus Study Towards Older Rejuvenation]: An exploratory PK/PD study of mTOR inhibition in older human subjects
Pharmacological mTOR inhibition (mTORi) extends lifespan and healthspan in older mice, suggesting these medications may similarly slow the progression of age-associated deficits in...