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99,167 grants found
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Impact of preadolescent psychostimulants on neurophysiology and sleep/wake disturbances
PROJECT SUMMARY Children with attention-deficit/hyperactivity disorder (ADHD), whether taking stimulant medications or not, experience more sleep problems than their peers. These n...
The functional logic of local circuits in auditory and parietal cortices
Project Summary The cortical column is a fundamental unit of processing in the cerebral cortex. Within each column are subnetworks of interconnected excitatory and inhibitory neuro...
Characterization and optimization of single dose, thermostable and durable vaccine platform towards increased clinical acceptance
SUMMARY/ABSTRACT Broadening the spectrum of vaccine platforms that confer protective, durable and broad immunogenicity is important for pandemic preparedness. Here, we aim to creat...
Modeling Health Equity and Economic Impacts of National Strategies to Address Food and Nutrition Insecurity
PROJECT ABSTRACT With worsening food insecurity in the COVID-19 pandemic and rising food prices, a 2022 White House initiative sought to address diet-related diseases (e.g., obesit...
Balance Dysfunction Induced by Lassa Virus Infection
PROJECT SUMMARY/ABSTRACT Lassa virus (LASV) infection causes Lassa Fever (LF), a hemorrhagic fever endemic to West Africa. Up to 30% of LASV infection survivors develop sudden onse...
The Role of the CES1 in the Pathogenesis of Pulmonary Arterial Hypertension
Pulmonary arterial hypertension (PAH) is a life-threatening disease characterized by abnormally elevated pulmonary pressures and right heart failure resulting in high morbidity and...
Cytoskeletal pathways of cerebellar dysregulation in neurodevelopmental disorders
PROJECT SUMMARY βII-spectrin, a ubiquitous component of the neuronal cytoskeleton, plays multifaceted roles in the organization and function of neurons. We recently reported that d...
An exploratory sequential mixed methods study on pregnancy loss care
Project Summary: Since the Dobbs v. Jackson Women’s Health Organization Supreme Court decision in June 2022, multiple states have implemented abortion bans. While not the intended...
Prevention of Attachment Insecurity, Physiological Dysregulation, and Child Behavior Problems
A growing body of scientific evidence demonstrates that secure attachment and sensitive caregiving are important sources of resilience for children living in stressful environments...
Improving knockout capacity for Coccidioides
Project 1 Supplement Summary: Virulence Gene Discovery in Coccidioides The focus of Project 1 is virulence gene discovery in Coccidioides. Despite the impact of Coccidioides infect...
Testing a Mindfulness-Based Intervention with a Multi-Modal Adaptive Supplement for Stress-Related Problems in College Students
Abstract There have been dramatic and concerning increases in rates of psychological distress in students enrolled in U.S. colleges and universities over the last decade. The major...
Circular RNA Role in Ovarian Follicular Development and Fertility
Project Summary Ovarian follicles undergo a series of dynamic changes following the ovulatory surge of luteinizing hormone including cumulus expansion, oocyte maturation, ovulation...
Evaluating the impact of altered gene expression on uterine fibroid risk in African ancestry populations
PROJECT SUMMARY Uterine fibroids, benign tumors of the uterus, affect 77% of women by menopause in the U.S. and account for up to $34 billion in annual healthcare costs. Black wome...
IL-22-STAT3-Nos2 axis in alcohol-mediated exacerbation of UC pathology
Project Summary/Abstract Alcohol use is a risk factor in multiple disease conditions including gastrointestinal related diseases. Recent findings from our laboratory show that alco...
Infertility and Long-Term Health Outcomes Among Hispanic Women with Mexican Heritage
PROJECT SUMMARY Hispanic women are up to 70% more likely to experience infertility (i.e., trying to conceive for ≥12 months without success), compared to non-Hispanic white women i...
Mapping postnatal oxytocinergic system and offspring neurobehavior after induced birth with oxytocin
Project Summary/ Abstract Exogenous oxytocin (OT) is widely used for the induction of labor in pregnant women. Though induction of labor with OT confers many maternal and neonatal...
Informing optimal investments along the preconception to postpartum eMTCT continuum
PROJECT SUMMARY/ABSTRACT While expansion of antiretroviral therapy (ART) coverage over the past two decades has significantly decreased mother-to-child, or “vertical,” transmission...
CHCHD10 Frontotemporal Dementia, Molecular Mechanisms and Therapeutic Strategies
Coiled-helix-coiled-helix domain containing protein 10 (CHCHD10, D10) is the first mitochondrial protein to be associated with familial frontotemporal dementia and amyotrophic late...
USDHub: community resource for Urinary Stone Disease research
ABSTRACT Urinary stone disease (USD) is highly prevalent and contributes a substantial proportion of healthcare costs related to kidney and urologic disease. Approximately half of...
Improving IL12 Immunogene Therapy for Glioblastoma Based on Human Clinical Trial Results
PROJECT SUMMARY Glioblastoma (GBM), one of the most fatal of cancers, remains impervious to treatment with the current standard of care (SOC) therapies. Even immunotherapies like i...