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99,167 grants found
Showing 2,601 – 2,620 of 99,167 grants
Advancing Multi-bNAbs Microneedle Patch Technology For HIV-1 Prevention in Breastfeeding Infants.
PROJECT SUMMARY / ABSTRACT Despite significant progress made in preventing perinatal mother-to-child-transmission of HIV, 2022 saw about 130,000 new HIV infections in children glob...
Diversity Supplement to Molecular and Cellular Basis of PCB Developmental Neurotoxicity (Mendieta)
PROJECT SUMMARY Lower-chlorinated polychlorinated biphenyls (LC-PCBs) are increasingly recognized as a significant risk to human health, and a primary target of concern is the deve...
Disrupting MDSC-fibroblast interactions to overcome chemoimmunotherapy resistance in pancreatic cancer
PROJECT SUMMARY Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy projected to be the 2nd leading cause of cancer-related deaths in the United States by 2030, with a d...
Overcome immunodominance to support the development of universal influenza vaccines
PROJECT SUMMARY An ideal "universal flu vaccine" should have the ability to trigger broadly protective antibody and humoral memory responses against both existing and fut...
Targeted ablation of bladder-resident uropathogenic bacteria with a novel cell penetrating dye
Urinary Tract Infections (UTIs), one of the most prevalent bacterial infections globally, present a formidable health challenge, especially considering that 25-50% of UTIs, even wi...
Multilevel Peer-to-Peer Education Program to Increase HPV Vaccinations and Wellness in School Based Health Centers (PEER)
PROJECT SUMMARY/ABSTRACT: Human papilloma virus (HPV) infection causes over 30,000 cancers each year, even though multi-valent vaccinations for HPV have been available since 2006....
CRCNS: Multimodal network interactions for internal state dynamics of resiliency
Resiliency to stress is crucial to the health of individuals and of society. While the detrimental effects of prolonged stress are well-documented, there remains a critical knowled...
Targeting silent cerebral infarction to improve long-term neurologic outcomes in immune thrombotic thrombocytopenic purpura (iTTP)
PROJECT SUMMARY/ABSTRACT Immune thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening disorder characterized by acute episodes of systemic microvascular thrombosis...
Unraveling Racial and Ethnic Disparities in Non-Pharmacologic Approaches for Medicaid Patients with Back Pain
Project SummaryMany non-pharmacologic therapies (NPTs) such as massage, acupuncture, and chiropractic treatments are now covered for the treatment of back pain under Oregon Medicai...
Biological and social determinants of psychosocial sequelae in advanced head and neck cancer survivors receiving immunotherapy
ABSTRACT The goal of this study is to understand psychosocial sequelae and their biological and social determinants among patients with advanced head and neck cancer (HNC) receivin...
Developing informatics tools to predict virtual spatial transcriptomics data with single-cell resolution in large-scale studies
PROJECT SUMMARY Recent developments in spatial transcriptomics (ST) technologies have enabled the comprehensive profiling of gene expression across tissues while preserving crucial...
Talking about Cannabis: Developing an Intervention for Family Members of Young Adults with FEP to Support Reduced Cannabis Use
Young adults (age 18-35) living with psychosis (YA-P; schizophrenia spectrum disorders) have high rates of heavy cannabis use that are associated with long-term deleterious mental...
Identifying the role of lipid accumulation and foam cells in benign prostate disease
PROJECT SUMMARY/ABSTRACT Benign prostatic pathological changes (collectively known as Benign Prostatic Hyperplasia/BPH), characterized by lower urinary tract symptoms (LUTS), is a...
Developing extracellular vesicle-mediated targeted microRNA delivery system for EGFR cancers
Title Developing extracellular vesicle-mediated targeted microRNA delivery system for EGFR cancers Project Summary Targeted therapy acts on a well-defined molecular mechanism of di...
Optimizing mRNA sequences with deep neural networks
The COVID-19 pandemic has presented new challenges to individuals world-wide. Since the first reports of infections in the US more than 90 million individuals have become infected...
Bio-engineered Cell Therapy to Treat Candidiasis
PROJECT ABSTRACT Patients with hematological malignancies, and immunocompromised patients are highly susceptible to Candida infection. Based on the immune status of the host, the i...
Mechanisms of IFNg-independent T cell and B cell-mediated protection in TB.
In humans, exposure to Mycobacterium tuberculosis (Mtb) results in varied infection and disease outcomes. 5- 10% of individuals infected with Mtb manifest disease, with evidence of...
Understanding the chlamydial developmental cycle at the single cell level
“Understanding the chlamydial developmental cycle at the single cell level”. Project Summary/Abstract The bacteria in the chlamydiales order are obligate intracellular parasites of...
Leveraging Extensive Social Determinants Data and Spatial Data Science to Reduce HIV Incidence across the United States Ending the HIV Epidemic Counties
PROJECT SUMMARY/ABSTRACT Geographic and racial/ethnic disparities in rates of HIV diagnosis and pre-exposure prophylaxis (PrEP) uptake are wide and persist. The Ending the HIV Epid...
Perceptual Adaptation Following Cochlear Implantation
Cochlear implants (CIs) are neural prosthetic devices that successfully restore hearing. However, understanding speech from CIs does not happen instantaneously. Speech understandin...