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99,167 grants found
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A map of ribosomal RNA regulation in human hematopoiesis
Project Summary / Abstract The hematopoietic tree contains cells of varying sizes, functions, and proliferation kinetics, and each cell type has a tightly regulated number of ribos...
Cell-cell and cell-matrix interactions driving progressive fibrosis in interstitial lung diseases
Project Summary Interstitial lung diseases (ILD) are a large group of lung diseases that are characterized by chronic, progressive pulmonary fibrosis. We hypothesize that in all IL...
Quantifying phenotypic adaptation of biological systems in dynamic environments
PROJECT SUMMARY/ABSTRACT Despite recent experimental advances in high-dimensional time-course data generation and accompanying inferential statistical approaches, we still lack the...
Standardizing and Harmonizing Behavioral and Social Science Research Factors in Alzheimer's Disease through Ontology-Based Approaches
ABSTRACT Behavioral and social science research (BSSR) is instrumental in comprehending Alzheimer's Disease and related dementia (ADRD) and its far-reaching implications for i...
2/7 PsycheMERGE: Advancing Precision Psychiatry
PROJECT SUMMARY Psychiatric disorders remain a leading cause of disability in the US and are associated with increased morbidity and mortality. Early detection and treatment is ess...
The BLAAST Trial: Bangladesh Lung Auscultation AI for Antibiotic Stewardship Randomized Controlled Trial
PROJECT SUMMARY: This is a submission for a National Institutes of Health R01 award called The BLAAST Project, which aims to conduct a randomized, double-blinded, placebo, non-infe...
Exploring the complex interactions between gut microbes and mucus
Project Abstract: The human gastrointestinal tract houses a diverse community of commensal gut bacteria that actively participate in maintaining host health. Among the intricate an...
Transcription Factor Network-Mediated Modulation of Transitional Senescence States
Abstract. The maintenance of a differentiated cell type (i.e., cell identity), a feature established by cell type- specific transcriptional programs, is critical for cell function...
The role of lymphatics in cholestatic liver disease
SUMMARY Cholestatic liver diseases such as primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC) are autoimmune liver diseases with limited treatment options....
Interaction of sickle cell trait with human apolipoprotein E ε4: Impact on brain structure, brain lipidomics, neuroinflammation and cognitive deficit
ABSTRACT With an increasing proportion of the population at older ages (i.e., the ‘graying of America’), there is a growing prevalence of Alzheimer’s Disease and Related Dementias...
Reducing anemia among young, preconception women in Nepal through a household level group norm and behavior change intervention and micronutrient supplementation
ABSRACT Preconception micronutrient status (including anemia) is a critical determinant of maternal, newborn, and child health that remains undervalued in Nepal. However, providing...
Precision Engineering of STING-DC Immunity to Overcome Tumor Immune Evasion
Abstract Host defense responses by the mammalian immune system can be very potent but require exquisite spatio-temporal coordination. This coordination is essential to match the im...
improving Health and Housing Outcomes through a Simulation and Economic Model (iHOUSE Model)
PROJECT SUMMARY Homelessness increased by 45% from 2020 to 2021, largely from economic hardship caused by the COVID-19 pandemic and has reached all-time highs across the US. More t...
Understanding putative beta-cell subtypes
PROJECT SUMMARY Type 2 diabetes (T2D) is a disease that results from relative pancreatic β-cell dysfunction, and affects >400 million people. We (Rutter) previously identified f...
Biased AKAP signaling mechanisms
ABSTRACT Enzymes do not drift aimlessly within a cytoplasmic soup. Rather cell regulatory events occur within the confines of highly organized intracellular signaling nanodomains....
Advanced Provider Care Models and Health Outcomes of Nursing Home Residents with Dementia
PROJECT SUMMARY The quality of care for the over 800,000 residents of US nursing homes (NH) with Alzheimer's disease or related dementias (ADRD) is variable and outcomes are p...
Pediatric Solid Tumor Microenvironment Atlas
OVERALL SUMMARY/ABSTRACT The majority of solid tumors in children have a unique origin compared to those in adults, stemming from their rise from embryonic cells. Despite this dist...
Lipoprotein (a) Modification of the Impact of HIV Infection on Atherosclerotic Cardiovascular Disease
PROJECT SUMMARY: People with HIV (PWH) experience a heightened risk of atherosclerotic cardiovascular disease (ASCVD) that is attributed, in part, to chronic inflammation. Lipoprot...
Impact of geographic mobility on PrEP and HIV care outcomes among Latino gay, bisexual and other men who have sex with men
Abstract HIV continues to be a major public health concern for Hispanic/Latino gay, bisexual and other men who have sex with men (GBMSM) in the U.S. Immigrant/migrant Latino GBMSM...
Non Invasive Measurements of Muscle Microstructures Assessed by Diffusion Tensor Imaging
PROJECT SUMMARY Skeletal muscle exemplifies structure-function relationships in biology. The organization of sarcomeres follow hierarchical ordering to form long contractile cells,...