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99,167 grants found
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Alternative Splicing and Development of Small Molecule Therapeutics in CAG Expansion Spinocerebellar Ataxias
Project Abstract Microsatellite repeat expansions are a growing family of 50+ neurological, neuromuscular, and neurodegenerative diseases that includes the most common cause of adu...
Vascular MicroRNA-212 in CAA and Alzheimer's disease
Supplement Summary and Aims The funded grant aims to determine the role of microRNAs (miRNAs) in post- transcriptional regulation in the context of cerebrovascular dysfunction and...
Trisomy 21 and its impact on hedgehog-dependent gene regulation and differentiation timing
PROJECT SUMMARY The fundamental question for the field of Down Syndrome (DS) basic research is how an extra copy of human chromosome 21 (HSA21) translates into the organ-specific p...
Neuronal anatomy, connectivity, and phenotypic innervation of the knee joint
Project Summary Severe pain caused by osteoarthritis (OA) affects over 15 million individuals in the United States alone. This degenerative joint disorder not only poses a signific...
Assessing effects of air pollution exposure on trophoblast cell mRNA and EV miRNA expression.
SUMMARY Air pollution is a ubiquitous environmental exposure that is consistently linked to adverse developmental trajectories in animal and human studies. However, the definitive...
Epigenetic Regulation of the Maturation and Function of Lung Epithelium by the SWI/SNF Proteins ARID1A and ARID1B.
PROJECT SUMMARY: It is being increasingly recognized that changes in chromatin state are associated with a wide spectrum of lung diseases, ranging from bronchopulmonary dysplasia (...
Diversity Supplement for “Post-translational regulation of LDLR”
ABSTRACT Elevated plasma LDL cholesterol is the main risk factor in cardiovascular disease (CVD), the leading cause of death in the United States. Cholesterol levels are regulated...
Post-transcriptional regulation of germline mRNAs in C. elegans
Project Summary: My lab is interested in defining how the maternal load is established during oogenesis and decoded after fertilization. We know the identity of most important mate...
Equipment for the sensitive and quantitative detection of proteins and nucleic acids
Project Summary/Abstract A substantial fraction of human inherited disease-causing mutations introduce an early stop codon that truncates protein production and elicits mRNA decay...
Two-way Magnetic Resonance Tuning Nanoprobe Enhanced Subtraction Imaging for Precision Diagnosis of Brain Metastasis
Title: Two-way Magnetic Resonance Tuning Nanoprobe Enhanced Subtraction Imaging for Precision Diagnosis of Brain Metastasis Project Summary/Abstract Metastasis from systemic cancer...
LYMPHEDEMA THERAPY VIA LYMPHATIC TARGETED DRUG DELIVERY
Contact PD/PI: Thomas, Susan Napier PROJECT SUMMARY Lymphedema, which results from the failure of the lymphatic system to properly drain fluid, proteins, lipids, and immune cells f...
Bright IDEAS-Young Adults: Problem-Solving Skills Training to Reduce Distress among Young Adults with Cancer
Project Summary/Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA- 24-041: Administrative Supplements for Asse...
Endometriosis Diagnosis and Subtypes, Reproductive History, and Cardiovascular Disease
ABSTRACT This diversity supplement application is to support the career development of Dhara Richardson, MSPH. Ms. Richardson is currently a PhD student in Epidemiology at the Mel...
3D real-time super-resolution cavitation mapping in laser lithotripsy of urinary stone disease
Laser lithotripsy (LL) is commonly used for kidney stone treatment, with cavitation playing a crucial role in stonefragmentation. However, the relationship between cavitation activ...
Epigenetic mechanisms linking discrimination stress with coronary heart disease in minoritized individuals
Project Summary Psychosocial stress has been repeatedly associated with immune dysregulation and increased risk for coronary heart disease (CHD), but the mechanisms underlying this...
Elucidating the functions of red blood cell factors in malaria parasite invasion
PROJECT SUMMARY/ ABSTRACT Malaria is a leading cause of morbidity and mortality globally, responsible for the deaths of hundreds of thousands of individuals per year, primarily chi...
Social Health, Activity Behaviors, and Quality of Life among Young Adult Cancer Survivors: A longitudinal Study Administrative Supplement
Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as "NOT-CA- 24-041.” A growing population of survivors of young ad...
Improving Survivorship Care for Adolescents and Young Adults: a Mixed Methods Study of Alignment with the National Standards for Survivorship Care
PROJECT SUMMARY/ABSTRACT This application is being submitted in response to the Notice of Special Interest (NOSI) identified as "NOT-CA- 24-041”. This proposal aims to investi...
A Coordinated National Approach to Supporting, Promoting, and Implementing FDA's Produce Safety Rule and the Produce Regulatory Program Standards
PROJECT SUMMARY Since establishing a multi-state Technical Working Group in 2013, the National Association of State Departments of Agriculture (NASDA) has been working with the Uni...
HIV Rev-Rev Response Element Activity Variation in Transmission and Latency
Project Summary/Abstract Advances in antiretroviral therapy have made ending the HIV pandemic an increasingly plausible prospect. Unfortunately, more than a million new HIV infecti...