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99,167 grants found
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Striatal Contribution to the Motor Symptoms and Aphasia in GRN-FTD
Frontotemporal dementia (FTD) represents 10 to 20% of all dementia cases. GRN mutations account for up to 20 percent of familial and 5 percent of sporadic FTD. Homozygous GRN mutat...
Ableism as a Mechanism of Physical and Mental Health Inequities Among Children with Visual Impairment
PROJECT SUMMARY Ableism as a Mechanism of Physical and Mental Health Inequities Among Children with Visual Impairment According to the Centers for Disease Control, approximately 3%...
A Continuing Education Intervention to Address Ableism Among Obstetric Clinicians Providing Perinatal Care
PROJECT SUMMARY The notion that disabled people would seek pregnancy and motherhood defies long-held social norms and is fraught with echoes of the eugenics movement of early 20th...
Integrative Model of Metabolomics, Equol and Atherosclerotic cardiovascular disease (IMMEA)
PROJECT SUMMARY This proposal, IMMEA (Integrative Models of Metabolites, Equol and Atherosclerotic cardiovascular disease), aims to (1) determine the association of equol-producing...
Evaluation of individual FMT as a potential therapeutic to reduce ethanol drinking in mice
Summary Few safe and effective pharmacotherapies exist for alcohol misuse. Alcohol consumption directly effects the gut microbiome, altering its diversity and leading to increased...
Receptor Cd74 integrates meta-inflammation in alcohol-associated liver disease
PROJECT SUMMARY The role of inflammation in alcohol-associated liver disease has been thoroughly researched over the past few decades. Despite this intensive focus on ALD pathophys...
Functional characterization of lysosome membrane and its protein quality control system
PROJECT SUMMARY The lysosome is an important organelle responsible for digesting and recycling materials, nutrient sensing, and controlling cell proliferation. It is also linked to...
Chemical synthesis to access rare heterocycles and tool compounds to probe bacterial polysaccharide metabolism
Abstract Two emphasis areas are proposed which are underpinned by synthetic organic chemistry. First, new synthetic methodology to access exceptionally rare nitrogen-rich compounds...
Cytokinesis and the Septin Cytoskeleton
Project Summary/Abstract: Cytokinesis is fundamental to life, and the septins form cytoskeletal scaffolds or diffusion barriers of distinct architectures to impact diverse cellular...
Calcium encoding mechanisms in a model plant
All eukaryotes relies on calcium ion (Ca2+) as a second messenger to respond to internal and external signals. Defects in Ca2+-based signaling cause numerous human diseases. Despit...
Development of Computational Tools and Their Applications to Various Biological Systems
PROJECT SUMMARY Biological macromolecules work together in a complex network to carry out essential cellular functions in living organisms. Understanding this complex network of in...
Aging Neural Systems and Communication Difficulties
PROJECT SUMMARY/ABSTRACT Age-related speech recognition difficulty and its association with poorer memory, increased fatigue, social isolation, and cognitive decline are major publ...
Charting Positive Valence Systems Trajectories in Offspring of Depressed Mothers to Predict Internalizing Symptoms in Early Childhood
PROJECT SUMMARY Offspring of mothers with depression are 2 to 3 times more likely than offspring of never-depressed mothers to develop anxiety and depressive disorders. Meta-analyt...
Evaluating and Optimizing Novel nSMase2 Inhibitors in the Treatment of Cancers
PROJECT ABSTRACT / SUMMARY: Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, but many patients fail to respond. Expanding the response to ICIs is a major g...
Disparities in cardiovascular health in young adults with type 1 diabetes
PROJECT SUMMARY Cardiovascular disease (CVD) is the leading cause of death for people with type 1 diabetes (T1D), and abnormalities preceding overt CVD (left ventricular hypertroph...
Metabolic Mechanisms of Recovery in Mild TBI
Project Summary The occurrence of concussion, or mild TBI, has been steadily increasing in incidence over the past decade. One possible consequence of concussion - post-concussion...
Lifecycle of obesogenic gender behaviors and cardiometabolic disease in women
Project Summary: Maternal obesity with increased circulating inflammatory markers can lead to adverse pregnancy outcomes, such as preeclampsia (PE). Clinical signs of PE include ma...
Clinical Translation of a Large Oncosome-Based Prostate Cancer Blood Test
ABSTRACT - The focus of this proposal is on lethal, metastatic prostate cancer (PC). The aim of this study is to develop an innovative, minimally invasive, liquid biopsy assay that...
Evaluating the roles of healthcare and community factors on healthcare disparities among aging immigrants
PROJECT SUMMARY/ABSTRACT Latinxs are aging faster than other racial/ethnic group in the US. By 2050, they are projected to be the largest share of the immigrant, older population....
The Impact of Biological Mechanisms of Aging on Response Variability to Resistance Training in Older Adults (BRIO)
SUMMARY In most individuals, exercise counters the onset and progression of chronic diseases (e.g., type 2 diabetes, cardiovascular disease, cognitive decline, and cancers), geriat...