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99,167 grants found
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Rational Design of Nickel Catalysts for Directing Group-Assisted Alkyne Hydrofunctionalization
PROJECT SUMMARY Nickel-catalyzed cross-coupling reactions have become a widely used method in chemical synthesis. A recent milestone in Ni catalysis was the advancement of C-N and...
Effects of chronic intermittent hypoxia on cholinergic modulation at hypoglossal motoneurons
Project Summary/Abstract Exposure to chronic intermittent hypoxia (CIH) is a common consequence of obstructive sleep apnea (OSA) where patients experience repeated apneas and hypop...
Sex and Gender Differences in Language Impairment, Disability, and Service Receipt
PROJECT SUMMARY/ABSTRACT Community research samples reveal near parity in the ratio of boys to girls who meet criteria for developmental language disorder (DLD); however, in 2020-2...
Metabolomic and genomic expansion of type 2 diabetes subtyping in multiethnic populations
Project Summary/Abstract Type 2 diabetes (T2D) involves derangement in multiple tissues, yet the physiological drivers of disease will vary and are difficult to discern for a given...
Behavior-Opportunity Gaps and Midlife Cognitive Health: Geographical Linkages to Enrich an Ongoing Longitudinal Family Study of Dementia Risk in a Minoritized Population
PROJECT SUMMARY Approximately 40% of Alzheimer’s Disease (AD) cases in the U.S. (and 56% in Latin America) are due to modifiable lifestyle factors such as hypertension, obesity, ph...
Auto-aligning hand-held OCT and OCTA for pediatric applications
This Exploratory/Developmental Research Grant proposal seeks to advance the state of the art of pediatric diagnostic retinal imaging with a novel, auto-aligning hand-held optical c...
New detection paradigms for laser-scanning microscopy leveraging fiber optical amplifiers
SUMMARY Laser scanning microscopy (LSM) – including optical coherence tomography (OCT), confocal and multiphoton microscopy (MPM) – allows imaging thick, living tissue at depth, an...
Precision Gene Editing on Osteogenesis Imperfecta
Project summary Osteogenesis imperfecta (OI) is the most common bone fragility disease, with an incidence of approximately 1 in 10,000-20,000 worldwide and 25,000–50,000 in the US....
Parents helping Parents for Youth Vaping Cessation (PhP-VX)
Project Summary Youth electronic cigarette (e-cigarette) use is a public health concern. Many youths are eager to quit vaping, and our prior study estimated that 67.3% of adolescen...
Developing a redox-mediated single NP detection for bioconjugate analysis.
Although immunoassays are a critical part of bioanalytical chemistry, the rapid and selective analysis of biomolecules continues to be a complicated aspect of biomedical research....
Early detection & monitoring of memory decline in a representative sample of older adults at risk for Alzheimer's disease and related dementias
Project Summary/Abstract Early detection and sensitive tracking of cognitive changes related to Alzheimer’s disease (AD) pathology (amyloid-Aβ and tau), particularly those that are...
Validation of penta-omic assays in brain tissue and identification of markers of tissue and -omic data quality
PROJECT SUMMARY There are hundreds of studies of Alzheimer’s disease, Alzheimer’s disease-related dementias, and other neurodegenerative diseases comparing post-mortem (PM) human b...
Rapid Development of Mouse Resource Strains through the Application of Prime Editors
PROJECT SUMMARY/ABSTRACT The human genome and that of its experimental surrogate, the mouse, contain a haploid DNA content of approximately three gigabase pairs (3 X 109 bp) and an...
Novel geometric deep learning models for tissue structure-aware spatial expression representations from spatially resolved single-cell transcriptomics data
Project Summary The continuing advancement of single-cell technologies has ushered us into an exciting era of single-cell spatially resolved transcriptomics (scSRT). scSRT by in-si...
Development of a nanobody tool kit to study connexin channels
There are 21 different connexin isoforms in human that play crucial roles in intercellular communication during development and physiology. At molecular level, six connexin protein...
Improving the Sensitivity and Selectivity of Laser Desorption Ionization Using N-Heterocyclic Carbene Mass Ionization Tags
PROJECT SUMMARY Even two decades after the complete sequencing of the human genome, a significant subpopulation (~10%) of the encoded proteins remains unknown. The questions surrou...
Exploring How Scene Segmentation Circuits Aid in Predicting Future Visual Input
PROJECT SUMMARY/ABSTRACT The dynamics of typical visual input challenge the brain: movement of objects or caused by navigation shifts visual information over the retina, and compli...
Designing Hydrogels that Recapitulate Physiological Cell-Matrix Adhesions
PROJECT SUMMARY Better model systems are needed to improve our understanding of how tissues develop, function, and regenerate in order to design more effective biomedical therapies...
Computational Models for Smart CO2 Monitoring
Project Summary Among the vital signs of human health, respiratory parameters are key indicators of the physiological status of the human body. Particularly important to clinicians...
Noninvasive assessment of in vivo tissue loads following treatment of volumetric muscle loss
PROJECT SUMMARY/ABSTRACT Volumetric muscle loss (VML) is a debilitating condition that leads to chronic functional impairment due to the irrecoverable loss of muscle tissue. There...