Development of a nanobody tool kit to study connexin channels

$2.01M USD

Funder	NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
Recipient Organization	University of California At Davis
Country	United States
Start Date	Sep 01, 2024
End Date	Aug 31, 2026
Duration	729 days
Number of Grantees	1
Roles	Principal Investigator
Data Source	NIH (US)
Grant ID	`10952384`

Grant Description

There are 21 different connexin isoforms in human that play crucial roles in intercellular communication during development and physiology. At molecular level, six connexin proteins assemble as hexamers to form an hemichannel that is inserted in the plasma membrane. The docking of two hemichannels from adjacent cells form a gap junction channel (GJC); both

hemichannels and GJCs are permeable to ions and small metabolites (