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European Clinical Research Alliance on Infectious Diseases
| Funder | European Commission |
|---|---|
| Recipient Organization | Stichting European Clinical Research Alliance On Infectious Diseases |
| Country | Netherlands |
| Start Date | Mar 01, 2021 |
| End Date | Feb 28, 2026 |
| Duration | 1,825 days |
| Number of Grantees | 25 |
| Roles | Participant; Third Party; Coordinator; Principal Investigator; Co-Principal Investigator |
| Data Source | European Commission |
| Grant ID | 965313 |
Grant Description
ECRAID-Base (European Clinical Research Alliance for Infectious Diseases) continues the activities of PREPARE, COMBACTE and ECRAID-Plan, which will lead to establishing ECRAID as an independent non-for-profit legal entity in December 2020.
ECRAID-Base is the initial set of activities for ECRAID.As a European clinical research network ECRAID-Base will generate rigorous evidence to improve diagnosis, prevention and treatment of infections and to better respond to EID threats.. The network has already been successfully used during the COVID-19 pandemic, with valuable lessons learned.
At the heart of ECRAID-Base are 6 perpetual studies; 5 observational studies in ICU (WP2), ER (WP3,4&5) and primary care (WP6), addressing infections relevant for AMR (VAP in WP2 & cUTI in WP3) and EID (ARI in WP4 & WP6, and Disease X in WP5). All will mature towards adaptive platform trials, with capability to rapidly respond to public health threats.
These 5 studies will enroll around 20,000 patients per year.
The sixth perpetual study is the Randomized Embedded Multifactorial Adaptive Platform (REMAP) for patients with severe CAP in ICU, with capability of rapid adaptation to new public health threats as demonstrated.
In a response to COVID-19 the platform was (within 2 months) adapted with new COVID-19 treatment domains and enrolment of non-ICU patients, and the number active sites rapidly increased in 213 sites (June 4th) with 1084 patients enrolled (567 with COVID-19).
Supportive to the clinical studies are work packages LAB (for laboratory support), DATA (for datamanagement and innovative epidemiological and statistical research), TRAIN (for training) and PREP (for improving responsiveness to new public health threats).
ECRAID-Base, therefore, establishes a pan-European clinical research network to increase efficiency for testing and developing new diagnostic, preventive and/or therapeutic strategies and therapies and improving responsiveness to new public health thretbd
All Grantees
Ecrin European Clinical Research Infrastructure Network; Centre Hospitalier Universitaire de Limoges; Universita Degli Studi Di Verona; Universiteit Antwerpen; Institut National de la Sante Et de la Recherche Medicale; Klinikum Der Universitaet Zu Koeln; Universite de Geneve; Fondazione Penta Ets; European Society Clinical Microbiology Infectious Diseases (Europaische Gesellschaft Fur Klinische Mikrobiologie Infektionskrankheiten); Fundacion Para la Gestion de la Investigacion En Salud de Sevilla; Universitair Ziekenhuis Antwerpen; Universitair Medisch Centrum Utrecht; Stichting Amsterdam Umc; Stichting European Clinical Research Alliance On Infectious Diseases; Intensive Care National Audit and Research Centre; Universitatsklinikum Heidelberg; The Chancellor, Masters and Scholars of the University of Oxford; Erasmus Universitair Medisch Centrum Rotterdam; Servicio Andaluz de la Salud; European Respiratory Society; Klinika Za Infektivne Bolesti Dr. Fran Mihaljevic; Fundacion Para la Investigacion Biomedica de Cordoba; University of New Mexico
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