A neurotech solution for sleep and memory improvement

Please watch our introduction video for a background explanation of the technology: https://youtu.be/f6Fvo7BU54w A detailed academic account of the technology is available at: https://youtu.be/Z89HlxG_glQ The sleep lab of the Psychology department at the University of Amsterdam has developed a unique procedure to target stimuli to specific patterns in on-going brain activity: closed-loop neurostimulation (CLNS).

This ground breaking technology allows precise manipulations of brain activity and opens the way to exciting applications. For one, CLNS can be used to enhance sleep by boosting slow oscillations, the hallmark of deep sleep. This is achieved by presenting non-arousing sounds in phase with these brain oscillations.

These subtle sounds do not disturb the sleeper, but enhance the sleep oscillations.

The spread of sleep problems in modern societies has reached epidemic proportions and adequate treatment options to manage this problem are urgently needed. Moreover, CLNS can be used to enhance or depress memory performance.

The method involves memory reactivation during sleep, through presentation of subtle auditory memory cues to the sleeper. Memory reactivation can be targeted to brain states that will either enhance or degrade the memory. Memory problems are ever-increasing in our aging population, while treatment options are lacking.

Furthermore, memory manipulation might be used to treat disorders featuring maladaptive memories, such as post-traumatic stress disorder, phobias or addictions. Our technology has been implemented as a wearable that naïve users can self-apply in their home environment. Thus, CLNS has great potential as a safe and cost-effective solution for sleep and memory problems.

Given the current explosive growth in self-monitoring and self-care applications, we think this is the right time to explore market penetration.

Our aim is to bring our technology to market, first in the form of a research-grade product aimed both at obtaining feedback on possible applications and at generating a first revenue stream while increasing market awareness; second, as a clinical device providing a solution for sleep enhancement and memory improvement.