Engineered Nanoparticles Targeting Hair Follicles for Alopecia Areata Treatment

Alopecia areata (AA) is a common autoimmune disorder resulting from damage of the hair follicle by cytotoxic T cells and characterized by non-scarring hair loss.

This project intended for preventive treatment AA brings together a highly motivated, experienced, and talented Researcher (Dr.

Matías Picchio), with a Polymer Chemistry background in biomaterials, hydrogels, and nanoparticle synthesis and properties improvement methodologies for biomedical applications, and POLYMAT, an innovative technological institute in the field of development of biomedical solutions based on nanohydrogels for the controlled release of therapeutic substances.

EngiNano-HF will focus on advancing the Experienced Researcher’s career through the development of the technology and manufacture stages of a new supramolecular polymer nanoformulation for the successful management of Janus kinase-inhibitors to prevent AA and associated complications. Under the supervision of Prof.

M.

Calderón, a globally recognized researcher, EngiNano-HF will proceed in a stepwise fashion using cutting-edge methodologies to prepare and physicochemically characterize the polymer nanocarriers.

The effect of the nanocarrier size, surface chemistry, surface charge, and mechanical properties on the hair follicle penetration and follicular delivery will be evaluated in porcine ear skin ex-vivo models. The most promising formulations will then be validated on a pre-industrial scale.

Three highly experienced teams RPT, CRC, and i+Med company will complement each other to meet the multidisciplinary expertise needed for EngiNano-HF.

This proposal is designed to allow the applicant to expand his research field significantly by receiving high-quality training-through-research and developing a new set of transferable skills.

Moreover, with the aim of achieving the highest possible social, industrial, and academic impact, this proposal covers multiple aspects related to exploitation, dissemination, and outreach activities.