Remote functionalization by a “deracemizing” metal walk – An innovative approach to define stereochemistry

In conclusion this proposal nicely combines a study of a Co-catalyzed remote hydroboration with a modern and conceptionally new approach to define stereochemistry through an elegant “deracemization” process mediated by a metal/ligand catalyst.

Through this method, branched alkyl chains en route to highly complex scaffolds with a well-defined stereochemistry should be accessible.

This strategy will be an invaluable asset to the scarcely existing methods creating multiple stereogenic centers in only one transformation (one could prepare 1,n-stereocenters through this approach).

Moreover, the anticipated remote functionalization delivers valuable enantiopure boronic esters, that might serve as interesting and important intermediates in natural product synthesis and medical chemistry.

Furthermore, mechanistic studies will give a better understanding of the proposed transformation and may pave the way for further remote transformations that involve a deracemizing metal-walk possessing branched alkyl chains (e.g. remote hydrosilylation).