Results for Health
130,725 grants found
Showing 128,521 – 128,540 of 130,725 grants for "Health"
Therapeutic Targets in Acute Chest Syndrome
SUMMARY This project is aimed at improving the health of individuals who have sickle cell disease (SCD) by defining a potential pro-survival factor of acute chest syndrome (ACS),...
Traumatic and Treatable Vascular Pathology in the Outcome of TBI
Objective: The overarching objective of this career development proposal is to develop Dr. Swanson’s translational approach for investigating the relationship between mild traumat...
Establishing the mechanism of benefit and dose of exercise required to improve liver histology in patients with nonalcoholic steatohepatitis
Establishing the mechanism of benefit and dose of exercise required to improve liver histology in patients with nonalcoholic steatohepatitis PROJECT SUMMARY— In this career devel...
Reaching Equity in ACess to Home Dialysis And Re-Transplantation (REACH-DART)
PROJECT ABSTRACT Kidney transplantation and home dialysis are the preferred treatment modalities for end-stage kidney disease (ESKD) given the better quality of life and lower co...
Fully Automated High-Throughput Quantitative MRI of the Liver
PROJECT SUMMARY: The overall goal of this application is to develop, implement and test a “single button push”, integrated combination of innovative MRI solutions to enable wide...
Translamina Cribrosa Pressure Gradient Model of Normal Tension Glaucoma
Neurodegenerative diseases, including glaucoma, substantially alter quality of life of our affected Veterans. Glaucoma remains a leading cause of irreversible blindness. Currently...
Metabolic Immunomodulation of Wound-Associated Macrophage Functional Plasticity as a Novel Diagnostic Target in Diabetic Veterans
Within the Veterans Affairs healthcare system, around 25% of military veterans have diabetes and the economic burden of lower limb amputations exceeded $200 million for fiscal yea...
Metabolic Immunomodulation of Wound-Associated Macrophage Functional Plasticity as a Novel Diagnostic Target in Diabetic Veterans
Within the Veterans Affairs healthcare system, around 25% of military veterans have diabetes and the economic burden of lower limb amputations exceeded $200 million for fiscal yea...
The Impact of Testosterone Use on the Vaginal Microbiota in Transgender Men, including Susceptibility to Bacterial Vaginosis
ABSTRACT: Transgender men (TGM) (persons who identify as male but assigned female sex at birth) often forgo gender- affirming surgery and retain their natal genitalia (i.e. vagi...
The Impact of Testosterone Use on the Vaginal Microbiota in Transgender Men, including Susceptibility to Bacterial Vaginosis
ABSTRACT: Transgender men (TGM) (persons who identify as male but assigned female sex at birth) often forgo gender- affirming surgery and retain their natal genitalia (i.e. vagi...
III:Small: Interpretable Deep Generative Models for Drug Development
Drug discovery is time-consuming and costly: it takes approximately 10-15 years and between $500 million to $2 billion to fully develop a new drug. Molecule optimization is a criti...
Direct-to-consumer genetic testing and donor-conception: support and governance in emerging digital systems
The growth in the use of direct-to-consumer-genetic testing (DTCGT) is having a major impact on sperm, egg and embryo donor conception (hereafter donor conception). Specifically, i...
Defining translational mechanisms to promote regenerative healing of chronic wounds
Defining translational mechanisms to promote regenerative healing of chronic wounds Abstract: Chronic wounds are common among our veterans, often impacting negatively on their abil...
Augmenting early phase substance use treatment with therapeutic work activity to improve clinical outcomes: a new indication for an old intervention
Approximately 1 in 15 Veterans currently meet criteria for a substance use disorder (SUD). SUDs have deleterious effects on interpersonal, role, and community function, and are hig...
Augmenting early phase substance use treatment with therapeutic work activity to improve clinical outcomes: a new indication for an old intervention
Approximately 1 in 15 Veterans currently meet criteria for a substance use disorder (SUD). SUDs have deleterious effects on interpersonal, role, and community function, and are hi...
Integrated use of genomics, metabolomics, and cytokine profiling to validate the use of 'dirty' mice to study sepsis pathophysiology
Each year ~2 million adult Americans develop sepsis and nearly 270,000 Americans die as a result of sepsis. In the U.S. VA health system in 2009, >35,000 Veterans were hospitalize...
Applying an 'omics' approach to predict hepatic decompensation events and hepatocellular carcinoma in veterans after HCV cure with direct acting antiviral therapy
The Department of Veterans Affairs is the single largest hepatitis C virus infection health care provider in the United States. Since the introduction of direct acting antivirals...
Augmenting early phase substance use treatment with therapeutic work activity to improve clinical outcomes: a new indication for an old intervention
Approximately 1 in 15 Veterans currently meet criteria for a substance use disorder (SUD). SUDs have deleterious effects on interpersonal, role, and community function, and are hi...
Defining translational mechanisms to promote regenerative healing of chronic wounds
Defining translational mechanisms to promote regenerative healing of chronic wounds Abstract: Chronic wounds are common among our veterans, often impacting negatively on their ab...
Applying an 'omics' approach to predict hepatic decompensation events and hepatocellular carcinoma in veterans after HCV cure with direct acting antiviral therapy
The Department of Veterans Affairs is the single largest hepatitis C virus infection health care provider in the United States. Since the introduction of direct acting antivirals...