Results for Health
130,725 grants found
Showing 128,461 – 128,480 of 130,725 grants for "Health"
Engineered exosomes carrying synthetic gRNA/Cas9 targeting HBV-infected cells
SUMMARY - Engineered exosomes carrying synthetic gRNA/Cas9 targeting HBV-infected cells Despite universal vaccinations against hepatitis B virus (HBV), chronic HBV infection remai...
Early Toxicity Detection Technologies via Exosomal Signatures in 3D Hepatic Tissues
Liver toxicity results in costly, late stage drug failures with 25-40% of drugs causing hepatic injuries through Phase I to Phase III clinical studies. Despite best efforts to ens...
Chilling time with synthetic torpor
Torpor can be thought of as a short term hibernation. It is a protective physiological strategy adopted by many different species (including mice) to conserve energy during environ...
Evaluation of oral administration of PRIM-DJ2727 capsule containing microbiota suspension in patients with severe alcoholic hepatitis: An Open-Label Study
Alcoholic hepatitis (AH) is a major public health problem in the United States, in which 30-50% die within the first 28 days. For the past few decades, steroid therapy has been th...
Collaborative Research: Bayesian Residual Learning and Random Recursive Partitioning Methods for Gaussian Process Modeling
Rare natural hazards (for example, storm surge and hurricanes) can cause loss of lives and devastating damage to society and the environment. For instance, Hurricane Katrina (2005)...
BBSRC-NSF/BIO: Anatomy and functions of LTP interactomes and their relationship to small RNA signals in systemic acquired resistance
Plants possess a unique form of immunity called systemic acquired resistance (SAR). SAR is highly desirable because it protects the whole plant against a wide range of pathogens an...
Validating p53 Ser46 crotonylation as a potential target for possible anti-cancer therapy
Project Summary Gut microbiota plays critical roles in maintaining human health, while their off-balance is highly associated with human diseases, including cancer. Some of them...
Validating p53 Ser46 crotonylation as a potential target for possible anti-cancer therapy
Project Summary Gut microbiota plays critical roles in maintaining human health, while their off-balance is highly associated with human diseases, including cancer. Some of them...
PIPP Phase I: Computational Theory of the Co-evolution of Pandemics, (Mis)information, and Human Mindsets and Behavior
Epidemiological models are used to predict the spread of highly contagious and lethal diseases such as COVID-19. Public health officials use such models to inform pandemic response...
Senior Research Career Scientist
Abstract: The Veteran population is skewed in terms of age, with more than 55% of Veterans already over 65 years of age. Older individuals with deficits in muscle size, strength...
Mechanisms of disordered citrate and oxalate excretion in nephrolithiasis
Project Abstract Kidney stones are a major cause of morbidity and account for $11 billion in health care spending in the U.S. Low urine citrate and high urine oxalate both increa...
Biology of Lymphangiogenesis in the Adult Lung
PROJECT SUMMARY/ABSTRACT The lung’s lymphatic system plays a critical role in lung health by maintaining fluid homeostasis and by serving as a conduit for immune cell trafficking...
Collaborate2Lose: Collaborating with romantic and non-romantic support persons to improve long-term weight loss
Background: Over 40% of Veterans have obesity, a risk factor for multiple chronic diseases. Weight loss interventions produce clinically significant weight loss, yet weight regain...
Bridging clinical trial and real-world data via machine learning to advance rheumatoid arthritis treatment strategies
PROJECT SUMMARY/ABSTRACT Rheumatoid arthritis (RA) is the most common autoimmune joint disease with over 15 treatment options, reflecting both advances in therapy as well as the...
VZV vaccine attenuation and the DNA damage response
ABSTRACT Diseases caused by the human herpesvirus Varicella Zoster Virus (VZV) are widespread and debilitating but can be limited by using live attenuated VZV vaccines. The varic...
Reducing Loneliness of Older Adults in Long Term Care Facilities through Collaborative Augmented Reality
Social connection is a critical health determinant essential in preventing loneliness (feeling of being alone or isolated). Loneliness is common among older adults with adverse con...
Blood-Biomarkers and Risk Factors of Acute Brain Injury associated with Neurodisability in Ugandan Children [BRAIN-Child]
ABSTRACT Neurocognitive impairment (NCI) is a common complication of acute brain injury in two unrelated nervous system disorders: cerebral malaria (CM) and traumatic brain injur...
Reducing Loneliness of Older Adults in Long Term Care Facilities through Collaborative Augmented Reality
Social connection is a critical health determinant essential in preventing loneliness (feeling of being alone or isolated). Loneliness is common among older adults with adverse con...
Blood-Biomarkers and Risk Factors of Acute Brain Injury associated with Neurodisability in Ugandan Children [BRAIN-Child]
ABSTRACT Neurocognitive impairment (NCI) is a common complication of acute brain injury in two unrelated nervous system disorders: cerebral malaria (CM) and traumatic brain injur...
Identification and Estimation of Dynamic Restricted Latent Class Models for Cognitive Diagnosis
This research project will advance dynamic, cognitive diagnostic assessments for tracking student skill acquisition as an alternative approach to the static classification of stude...