Results for Health
130,725 grants found
Showing 127,921 – 127,940 of 130,725 grants for "Health"
Origin and host adaptation of the novel canine coronavirus (CCoV-HuPn-2018) isolated from a human pneumonia patient
1 Project Summary 2 There is growing evidence that canine coronaviruses (CCoVs) can infect humans and be associated with 3 clinical (mostly acute respiratory) illness in childr...
Adverse pregnancy outcomes and long-term risk of cardiovascular disease in women
Pregnancy is a "natural stress test" that may reveal higher cardiovascular disease (CVD) risks in early adulthood, potentially long before the emergence of clinical CVD. Up to one...
Socio-ecological research to understand the potential impacts of alternative protein sources in the UK and Europe
The food system feeds societies, employs billions of people, and underpins international aspirations such as the United Nations Sustainable Development Goals. However, it is respo...
iCASE: High-throughput characterisation of the functional antibody epitope landscape of surface protein targets to guide vaccine and biologic design
Understanding the nature of antibody-antigen interactions and how these relate to functional outcomes is vital in guiding the rational design of next-generation vaccines and monocl...
Alcohol, Offending and Strong-Arm Sobriety: A Qualitative Longitudinal Study of Alcohol Treatment Requirements
This PhD is a highly original study of the experiences and perceptions of offenders sentenced to alcohol treatment requirements (ATRs) that will extend academic knowledge and shape...
Cens-able - Improving and empowering census data research opportunities in Scotland
Aims and Objectives We aim to improve and empower three census-linked products for the 2022 Scottish census. The three products we will work on are: Improving the Equalities Pr...
Measuring Digital Clinical Endpoints in Huntington's Disease (MEND-HD)
PROJECT SUMMARY (ABSTRACT) As genetic and disease-modifying interventions emerge, there is an urgent need for early and accurate assessment of disease-specific motor impairments...
SCH: Develop Clinical Time Series Foundation Models for Sepsis Early Detection
This project will advance national health and promote science and technology development by providing algorithms, software, and systems that can train foundation models on clinical...
Fatty acid remodeling of the translatome during fasting and aging
PROJECT SUMMARY/ABSTRACT From Greek philosopher Plato to recent animal and human studies, fasting has been recommended as a strategy to slow down aging and reduce the risk of ma...
Assessing the Mobility of Organic Chemicals Across the Sothern African Development Community
Background. The number and diversity of organic chemicals produced global is consistently increasing, as are the number of substances that are being detected in freshwater resour...
Sex-based study of chronic hypoxia-related vulnerability to depression: age effects
Risk for major depressive disorder (MDD) risk increases with aging. Later-life depression affects 12-40% of people over 65yrs old, with biological risk factors including female se...
A Phase 2C Randomized, Controlled, Open-Label Trial of Novel Shortened Regimens for the Treatment of Isoniazid-Monoresistant TB (IMR-TB)
Project Summary/Abstract Isoniazid-monoresistant (IMR) tuberculosis (TB) comprises 1.1 million (11%) of the estimated 10 million new TB cases annually. Recent scientific advances...
Integration of the PRODICT test into the prostate cancer risk pathway
Research Question: Can the PRODICT genetic test be implemented into the NHS pathway to risk-stratify a population to effect stage-shift in prostate cancer (PrCa)? Backg...
Patient led earlier mobilisation for COnservatively managed displaced Proximal humErus fractures (COPE): Intervention development and feasibility trial
Background Proximal humerus fractures (PHFs) are common and when managed conservatively are treated with a sling for around 6 weeks followed by physiotherapy-led exercises. There i...
Localizing Therapeutics to Target Lung Myofibroblasts and Reverse Fibrosis
Project Summary/Abstract Lung diseases are a global public health problem with significant morbidity, inadequate therapies and a very high burden to society. Of these, idiopathic...
AVA_ AI Video-Based Mobile Application for Reliable, Accessible, and Low-Cost Fall Risk Assessments of Older Adults
Abstract Falls are a significant issue for older adults, causing physical, emotional, and financial strain. Research indicates that regular and early fall screenings can reduce f...
Financial Impact of Support and Care in Alzheimer's disease and Related Dementias (FISCAL)
Family caregivers provide much of the support to people with Alzheimer’s disease (AD) and AD-related dementias (ADRD) living in the community. As a result, caregivers for people w...
ISS: Leveraging Microgravity to Study Immunomechanics in Cancer-Myeloid Organoids
The unique low gravity environment of the International Space Station (ISS) offers advantageous opportunities for gaining new insights into human health and disease. On Earth, dise...
Prospective validation of a radiomics-based multi-modal predictive model for metastatic non-small cell lung cancer patients treated with PD-1 immunotherapy
Summary PD-(L)1 checkpoint inhibitors are an effective class of oncology therapeutics, where some patients with non-small cell lung, bladder cancer and melanoma demonstrate durab...
Upregulating spinal circuits to enhance balance and walking and to increase spinal excitability in older adults
PROJECT SUMMARY/ABSTRACT A high proportion of older adults are currently or soon will be at risk for the well-known decline in walking and balance abilities that occur with aging...