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199,248 grants found
Showing 7,541 – 7,560 of 199,248 grants
FunHitDisco: A Fungal Hit Discovery Platform
The increasing threat of treatment-resistant fungal disease is of significant concern.With a limited number of drug classes available, it is imperative to focus drug discovery effo...
Phage-Antimicrobial combination Strategies for management of multidrug-resistant E. coli and K. pneumoniae
Multidrug-resistant bacterial infections constitute a major challenge, resulting in significant morbidity and mortality. One of the cornerstones of the management of AMR infections...
Revitalising the Antifungal Pipeline with Transition Metals
Fuelled by climate change, antifungal overuse, and a limited pipeline of novel drugs, antifungal resistance is a growing global health concern and innovative solutions are urgently...
FunHitDisco: A Fungal Hit Discovery Platform
The increasing threat of treatment-resistant fungal disease is of significant concern.With a limited number of drug classes available, it is imperative to focus drug discovery effo...
Linking functionally relevant characteristics of dissolved organic matter to functional traits of the microbial community (Fun-DOM)
All living biomass is comprised of organic matter.The degradation of dissolved organic matter (DOM) is critical for recycling energy and nutrients back into a functioning ecosystem...
Cancer in Adolescents and Young Adults and the Socioeconomic and Mental Health Consequences in Family Caregivers
Adolescents and young adults (AYAs) with cancer are predominantly treated in outpatient settings, presenting significant challenges for family caregivers, including parents, siblin...
Time-resolved X-ray Stark Spectroscopy to Quantify Charge-Transfer in Chemical Reactions and Catalysis
Catalysis with transition metals is driven by specific interactions between the metal and a molecule that ultimately enable the transformation of the latter. These interactions oft...
Unsteady Turbomachinery Flows in linear cascades
The vision outlined in this proposal is to understand and model truly unsteady turbomachinery flows, use novel software and high-performance computation to address flow physics and...
Trustworthy Bandit Algorithms for Precision Medicine
Contextual bandit algorithms learn personalized recommendation policies using data on individual responses to past recommendations.These machine learning methods are therefore part...
Water Plumes of the Icy Moons
Ocean Worlds like Europa, Enceladus, and Triton harbor a vast liquid water ocean beneath their icy crust, holding promise for discovering extraterrestrial life.However, assessing t...
Powerful knowledge in national tests in social studies subjects
The aim of this project is to investigate views of knowledge in national tests in civics, geography, history, and religion.In an era of post-truth and alternative facts, a fundamen...
TIPPING POINTS IN LIPID-PROTEIN CO-ASSEMBLY
α-synuclein is an intrinsically disordered protein implicated in synaptic vesicle trafficking.Accumulation of α-synuclein in the form of amyloid deposits coincides with the loss of...
Tracking terrestrialisation: Revealing the hidden origins of animal life on land
After billions of years confined to the oceans, the emergence of life onto the continents ranks among the most pivotal milestones in the history of our planet. Despite its signific...
Elucidating mechanisms of chronic airway disease; a life-course approach
Lung development starts in utero and continues during childhood, and can be altered by several host and environmental factors during the life-course.A range of lung function trajec...
Cancer drug-induceed gastrointestinal toxicity: Pathogenesis and future management
This project is dedicated to investigate mechanisms underlying cancer drug-induced mucositis (CIM) and to identify targeted therapies for CIM.We aim to gain a in-depth molecular un...
Combined molecular and mechanistic methods for early detection and individual prevention of pressure ulcer formation in vulnerable patients
This project aims to develop a novel method for identifying early tissue damage related to pressure ulcer (PU) development in vulnerable patients by measuring biomarkers of inflamm...
Molecular dissection of nutrition-induced ribosome frameshifts, from cancer to aging.
We have recently discovered a novel mechanism by which, in response to low nutrient conditions, most ribosomes experience a -1 ribosome frameshift. This process affects most genes...
Neutrophil Immunomodulation in Oral Squamous Cell Carcinoma: A focus on Tumor-Draining Lymph Nodes
Background: Despite aggressive surgery coupled with radiation/chemoradiation, the 5-year overall survival rate of oral squamous cell carcinoma (OSCC) has stagnated at 50% for decad...
Comparative genomics decoding of virus – host interactions
The purpose of this research is to generate new knowledge about virus-host interactions and evolution by investigating the endogenous retrovirus (ERV) record.Retroviruses convert t...
Neurotrophic Mechanisms in the Adult Nervous System: A Novel Molecular Pathway Regulating Reward and Addiction
The molecular mechanisms underlying the structural and functional adaptations in neuronal circuits involved in reward and drug addiction are incompletely understood.The main goal o...