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199,248 grants found
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Integrative machine and deep learning models for predictive analysis in complex disease areas
We aim to develop high-performance, explainable machine learning (ML) and deep learning (DL) models that can accurately predict severe outcomes in patients with complex diseases, s...
Development of a targeted All-in-One Delivery Vehicle (AiDV) for delivery of gene editing Homology-Directed Repair (HDR) components to specific cells in vivo to treat inborn error of immunity
The end goal of the project is to efficiently deliver Cas9 and a cDNA of a gene to integrate the cDNA site specifically by homology-directed repair (HDR) to treat inborn errors of...
An in vitro test method to replace in vivo osteomyelitis models
Orthopaedic implants are used to replace joints and enhance patient quality of life after trauma or disease. However, implant-associated infections threaten the success of such tre...
Modifiable risk factors for late cardiovascular complications after childhood cancer
Increasing survival rates for childhood cancer have resulted in a rapidly growing population of childhood cancer survivors at high risk of developing late cardiovascular complicati...
Risk factors, mediators, and biomarkers related to development of premenopausal breast cancer
Emerging research suggests that exposures occurring during pregnancy can pose risks to a woman’s health. One example is the risk of developing breast cancer, which is increased for...
Retina-Brain Nexus: Alzheimer’s Pathogenesis and Diagnostic Approaches
Previous research has shown cellular changes and accumulations of amyloid aggregates in the retina of patients with Alzheimer’s Disease (AD), potentially explaining visual impairme...
Long term outcomes after metabolic and bariatric surgery during adolescence
Adolescents with severe obesity are at high risk of severe health complications and have a reduced life expectancy.Obesity treatment is currently developing rapidly with obesity su...
ALS as a systems biology disease: Linking bioenergetic dysfunction with cell-cell miscommunication
Motor neurons (MNs) and skeletal muscle fibers need to maintain bidirectional communication to avoid synaptic breakdown and systemic failure of motor control. However, we do not un...
A new material for bone and ligament regeneration
This project addresses unmet needs within orthopedic care, focusing specifically on non-union fractures and anterior cruciate ligament (ACL) rupture, through the development of nov...
Exosome: The Survival Key of Malaria Parasite Through Promoting Plasmodium-Anopheles Interaction
The malaria parasite´s survival depends on its life cycle in human and mosquito. Plasmodium falciparum renders human more attractive to mosquito, increasing the risk of transmissio...
Therapeutic implications of bioactive nitrogen oxides in reno-cardiovascular and metabolic disorders
Background: Cardiovascular, metabolic, and renal disorders are closely interconnected, largely shaped by our lifestyle (physical inactivity & unhealthy diet), which often lead...
Modulating the ubiquitin-proteasome system in human diseases
The removal of misfolded or otherwise damaged proteins from the intracellular environment is of critical importance for cells as these aberrant proteins can give rise to toxic prot...
Stress, reward and homeostasis. Role of the brain´s neural networks and their interplay with peripheral tissues in type 2 diabetes development
PurposeTo explore whether an altered ‘glucostat’ function of the brain is instrumental in the development (and reversal) of type 2 diabetes (T2D).To elucidate the role of neural ne...
Defining the role of hemodynamic forces in shaping cardiovascular system morphogenesis.
Cardiac contractions, which propel blood throughout the organism, are essential for vertebrate development as well as the maintenance of physiological processes throughout the orga...
Longitudinal profiling of the aging plasma proteome to identify risk and resilience profiles in neurocognitive aging
Large-scale screening of the plasma proteome offers great potential for non-invasively predicting and understanding systemic contributory factors of age-related cognitive decline a...
Host-microbial interactions in oral mucosa immunopathology
Neutrophils are crucial for oral homeostasis but are also drivers of tissue damage in periodontitis, a common oral immunopathology. The mechanisms determining a protective or detri...
Unraveling Lipoprotein Maturation and Transport Pathways in Gram-Negative Bacteria: Pioneering Targets for Innovative Antibacterial Therapies
The escalating challenge of antimicrobial resistance underscores the urgent need to identify novel targets for antibacterial drug development.Despite the vast diversity of bacteria...
Non-motor symptoms and complications in Parkinson´s disease: modeling and identification of targets for therapy
The goal of this Research Project is to study non-motor symptoms associated with Parkinson’s disease (PD) and whith complications caused by dopamine replacement therapies.Psychiatr...
Interaction between sex steroids, physical exercise and metabolism in female reproduction and health
Reproductive dysfunction is frequent in women with hyperandrogenism and obesity, like polycystic ovary syndrome (PCOS). On the other hand, hyperandrogenism can be beneficial for ph...
Restoring immune fitness through biophysical manipulations
While the identification of “cell types” often relies on well-defined surface markers or transcriptional repertoires, characterizing “cell states” proves to be a more nuanced chall...