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199,248 grants found
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GLP-1 Receptor Agonists and Other Pharmacotherapy for Type 2 Diabetes and Obesity: Use and Safety in Pregnancy
Semaglutide and other GLP-1 receptor agonists (GLP-1 RA) have revolutionized the treatment of type 2 diabetes and obesity and their use in Sweden and globally has increased dramati...
TeamBirth and intervention to improve patient safety and person-centered care during childbirth
Most adverse events within maternity care stem from communication and teamwork failures.Despite national and international recommendations, few interventions include person-centere...
Remaining pain in rheumatoid arthritis – Therapeutic performance of different biological treatments and clinical relevance of a recently identified unexplored causative signalling pathway.
Pain in rheumatoid arthritis (RA) is highly debilitating, impacts quality of life and lacks adequate treatment options.Although biologics have proven benefits on inflammatory disea...
Study the targetome structures of OncomiR 34a to reveal the regulatory mechanism
MicroRNAs (miRs) are dysregulated in over half of all cancers and numerous other diseases.The efficiency of miRs´ regulation is primarily predicted based upon a 6-8 nucleotide base...
Chromosome-wide gene regulation, aneuploidies and chromosome segregation
Aneuploidy, characterized by the loss or duplication of entire chromosomes or chromosomal segments, often compromises overall fitness, and confers proliferative disadvantages.Despi...
To Understand and Predict the Impacts of Warming Climates on Plastics: Accelerated Degradation and Environmental Implications (WarmPlastix)
Global warming is intensifying, as seen in the extreme heatwaves of 2022 and 2023, leading to significant consequences like increased mortality and rampant wildfires.With these eve...
Vibrational Control in Organic Semiconductors
Organic semiconductors (OSCs) are carbon-based materials with great potential for photovoltaic (OPV) and light-emitting diode (OLED) applications.This project will improve our unde...
Hubble trouble: A new measure of the universal expansion using lensed supernovae
Modern cosmology can explain the evolution of the Universe using only six parameters, typically determined with sub-percent accuracy.They include the amount of dark matter, necessa...
Development and evaluation of the PeriBrainCare Bundle- a complex health intervention to support older persons in their neurocognitive recovery after cardiac surgery (ECPON part 2)
The number of older people who undergo complex surgical procedures continues to rise.Old age is a significant risk factor for the development of postoperative neurocognitive declin...
Apoptosis and efferocytosis as mechanisms of impaired fibrotic tissue repair in diabetes associated vascular complications
Individuals with type 2 diabetes (T2D) die prematurely due to cardiovascular complications caused by an aggravated arterial atherosclerotic plaque formation.We provided evidence fo...
Genetic variation influencing blood cancer risk and blood stem cell activity
We focus on how inborn genetic variation influences blood cell formation and blood cancer risk.In Project A, we will explore genetic predisposition to multiple myeloma (MM). Since...
Personalized pharmacological treatment of ADHD (Attention Deficit Hyperactivity Disorder)
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder marked by significant comorbidity and serious outcomes.The use of ADHD medication has sur...
Personalized pharmacological treatment of ADHD (Attention Deficit Hyperactivity Disorder)
Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder marked by significant comorbidity and serious outcomes.The use of ADHD medication has sur...
Prevention and Screening for Cancer in people with HIV – who and when?
Despite an increased risk of cancer in people with HIV, the only current HIV specific cancer-screening guideline is for cervical-cancer-screening, to which our research-group has e...
Novel innovative techniques for the prevention of hypoxia during anesthesia and in the critically ill - Oxygenation before and during anesthesia using high-flow nasal oxygen
The overall aim of this project is to generate novel approaches for prevention of acute hypoxia in the perioperative period and in critically ill patients.Novel technology for preo...
From mechanosensing to nuclear response: revealing the role of actin regulators for B cell diversification
The actin cytoskeleton functions in the nucleus, however its nuclear function in hematopoietic cells is largely unexplored.The Wiskott-Aldrich syndrome proteins (WASp) family coord...
Peripheral Nervous System in chronic pain.
The inflammatory response is a natural reaction to harm or infection and facilitates a healing environment.However, in some cases, the inflammatory state doesn’t resolve properly,...
Understanding clonal hematopoiesis and initiation of myeloid malignancies
Clonal hematopoiesis often precedes the development of myeloid malignancies, but a majority of these individuals do not develop leukemia. Little is known of this tumor evolution.We...
Investigation of immune evasion mechanisms in STK11 inactivated NSCLC
The purpose of this research is to provide new knowledge of immune evasion mechanisms in STK11 inactivated non-small cell lung cancer (NSCLC), a subtype comprising up to 30% of NSC...
Blood biomarkers after cardiac arrest - prognosis and prediction
Most cardiac arrest (CA) patients admitted to intensive care are unconscious and dependent of advanced therapies. The CA syndrome is heterogenous, which is considered a barrier to...